Mechanisms of inflammation in MS tissue: adhesion molecules and chemokines

Traffic signals for lymphocyte recirculation and leukocyte emigration: The multistep paradigm

1994 • 7,068 citations

Axonal Transection in the Lesions of Multiple Sclerosis

1998 • 4,007 citations

Chemokines — Chemotactic Cytokines That Mediate Inflammation

1998 • 3,660 citations

Homozygous Defect in HIV-1 Coreceptor Accounts for Resistance of Some Multiply-Exposed Individuals to HIV-1 Infection

1996 • 3,106 citations

Lymphocyte Homing and Homeostasis

1996 • 2,934 citations

Leukocyte-endothelial cell recognition: Three (or more) steps to specificity and diversity

1991 • 2,806 citations

Chemokines and leukocyte traffic

1998 • 2,755 citations

The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates

1996 • 2,326 citations

Human Chemokines: An Update

1997 • 2,235 citations

Chemokines

1997 • 1,926 citations

A Dual-Tropic Primary HIV-1 Isolate That Uses Fusin and the β-Chemokine Receptors CKR-5, CKR-3, and CKR-2b as Fusion Cofactors

1996 • 1,868 citations

Properties of the Novel Proinflammatory Supergene "Intercrine" Cytokine Family

1991 • 1,864 citations

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Selective attraction of monocytes and T lymphocytes of the memory phenotype by cytokine RANTES

1990 • 1,378 citations

The Molecular Biology of Leukocyte Chemoattractant Receptors

1994 • 1,224 citations

Monocyte chemoattractant protein 1 acts as a T-lymphocyte chemoattractant.

1994 • 1,190 citations

T‐lymphocyte entry into the central nervous system

1991 • 1,168 citations

Impaired monocyte migration and reduced type 1 (Th1) cytokine responses in C-C chemokine receptor 2 knockout mice.

1997 • 1,078 citations

The Neutrophil-Activating Protein (NAP-1) Is Also Chemotactic for T Lymphocytes

1989 • 1,060 citations

Chemokines and the Arrest of Lymphocytes Rolling Under Flow Conditions

1998 • 1,013 citations

Expression of specific chemokines and chemokine receptors in the central nervous system of multiple sclerosis patients

1999 • 999 citations

Purification of a human monocyte-derived neutrophil chemotactic factor that has peptide sequence similarity to other host defense cytokines.

1987 • 983 citations

The rapid isolation of clonable antigen‐specific T lymphocyte lines capable of mediating autoimmune encephalomyelitis

1981 • 917 citations

T-cell adhesion induced by proteoglycan-immobilized cytokine MIP-lβ

1993 • 896 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

The adhesion molecule and cytokine profile of multiple sclerosis lesions

1995 • 761 citations

Recombinant human interferon-inducible protein 10 is a chemoattractant for human monocytes and T lymphocytes and promotes T cell adhesion to endothelial cells.

1993 • 755 citations

Distinct Patterns of Multiple Sclerosis Pathology Indicates Heterogeneity in Pathogenesis

1996 • 741 citations

Preferential Migration of Activated CD4 ⁺ and CD8 ⁺ T Cells in Response to MIP-1α and MIP-1β

1993 • 737 citations

Transcytosis and Surface Presentation of IL-8 by Venular Endothelial Cells

1997 • 731 citations

Requirement of Mip-1α for an Inflammatory Response to Viral Infection

1995 • 636 citations

A Receptor for the Malarial Parasite Plasmodium vivax : the Erythrocyte Chemokine Receptor

1993 • 583 citations

Purification and amino acid analysis of two human glioma-derived monocyte chemoattractants.

1989 • 497 citations

Astrocyte expression of mRNA encoding cytokines IP‐10 and JE/MCP‐1 in experimental autoimmune encephalomyelitis

1993 • 496 citations

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

1995 • 487 citations

Neutrophil-activating protein 1/interleukin 8 stimulates the binding activity of the leukocyte adhesion receptor CD11b/CD18 on human neutrophils.

1990 • 478 citations

Macrophage inflammatory proteins 1 and 2: members of a novel superfamily of cytokines

1989 • 435 citations

Macrophages and the Nervous System

1991 • 429 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

Signals and Receptors Involved in Recruitment of Inflammatory Cells

1995 • 420 citations

Differential CC chemokine-induced enhancement of T helper cell cytokine production.

1997 • 417 citations

IP-10, a -C-X-C- chemokine, elicits a potent thymus-dependent antitumor response in vivo.

1993 • 414 citations

G protein-coupled signal transduction pathways for interleukin-8

1993 • 385 citations

Expression of chemokine receptors by subsets of neurons in the central nervous system.

1997 • 384 citations

Recombinant human MCP-1/JE induces chemotaxis, calcium flux, and the respiratory burst in human monocytes

1991 • 369 citations

The role of cytokines in the generation of inflammation and tissue damage in experimental gram-positive meningitis.

1990 • 367 citations

Nervous tissue as an immune compartment: the dialect of the immune response in the CNS

1994 • 366 citations

Chemokine expression in murine experimental allergic encephalomyelitis

1995 • 363 citations

Migration of Hematogenous Cells Through the Blood‐Brain Barrier and the Initiation of CNS Inflammation

1991 • 362 citations

Chemokine monocyte chemoattractant protein-1 is expressed by astrocytes after mechanical injury to the brain.

1996 • 311 citations

Purification and amino acid analysis of two human monocyte chemoattractants produced by phytohemagglutinin-stimulated human blood mononuclear leukocytes.

1989 • 304 citations

Chemokines and tissue injury.

1995 • 303 citations

Comparative Neuropathology of Chronic Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1983 • 295 citations

Identification of a promiscuous inflammatory peptide receptor on the surface of red blood cells

1993 • 292 citations

Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.

1997 • 284 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

A predictable sequential determinant spreading cascade invariably accompanies progression of experimental autoimmune encephalomyelitis: a basis for peptide-specific therapy after onset of clinical disease.

1996 • 270 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

Detection of MHC class II-antigens on macrophages and microglia, but not on astrocytes and endothelia in active multiple sclerosis lesions

1994 • 258 citations

Cloning of glycoprotein D cDNA, which encodes the major subunit of the Duffy blood group system and the receptor for the Plasmodium vivax malaria parasite.

1993 • 252 citations

Mechanisms of Immune Injury in Multiple Sclerosis

1996 • 242 citations

Homing to central nervous system vasculature by antigen-specific lymphocytes. I. Localization of 14C-labeled cells during acute, chronic, and relapsing experimental allergic encephalomyelitis.

1990 • 234 citations

Production and function of monocyte chemoattractant protein-1 and other β-chemokines in murine glial cells

1995 • 229 citations

Chemokine regulation of experimental autoimmune encephalomyelitis: temporal and spatial expression patterns govern disease pathogenesis.

1998 • 229 citations

The Chemokine Growth-Regulated Oncogene-α Promotes Spinal Cord Oligodendrocyte Precursor Proliferation

1998 • 227 citations

The Human Homolog of the JE Gene Encodes a Monocyte Secretory Protein

1989 • 227 citations

Molecular piracy of mammalian interleukin-8 receptor type B by herpesvirus saimiri.

1993 • 226 citations

Expression of CSF-1, c-fms, and MCP-1 in the central nervous system of rats with experimental allergic encephalomyelitis.

1993 • 218 citations

Selective chemokine mRNA accumulation in the rat spinal cord after contusion injury

1998 • 209 citations

Experimental allergic encephalomyelitis: the balance between encephalitogenic T lymphocytes and demyelinating antibodies determines size and structure of demyelinated lesions

1988 • 206 citations

Do chemokines mediate leukocyte recruitment in post-traumatic CNS inflammation?

1998 • 195 citations

Expression of the Duffy antigen in K562 cells. Evidence that it is the human erythrocyte chemokine receptor.

1994 • 192 citations

Experimental autoimmune panencephalitis and uveoretinitis transferred to the Lewis rat by T lymphocytes specific for the S100 beta molecule, a calcium binding protein of astroglia.

1994 • 186 citations

Cutting Edge Commentary: Chemokine Regulation of Experimental Autoimmune Encephalomyelitis: Temporal and Spatial Expression Patterns Govern Disease Pathogenesis

1998 • 182 citations

The interleukin-8-receptor family: from chemokines to malaria

1994 • 173 citations

Molecular properties of the chemokine receptor family

1994 • 170 citations

Chemokine-leukocyte interactions. The voodoo that they do so well

1996 • 167 citations

Chemokines and serpentines: the molecular biology of chemokine receptors

1993 • 167 citations

The immunopathogenesis and regulation of T-cell-mediated demyelinating diseases

1994 • 165 citations

Central Nervous System Chemokine mRNA Accumulation Follows Initial Leukocyte Entry at the Onset of Acute Murine Experimental Autoimmune Encephalomyelitis

1995 • 163 citations

C-X-C and C-C chemokines are expressed in the cerebrospinal fluid in bacterial meningitis and mediate chemotactic activity on peripheral blood-derived polymorphonuclear and mononuclear cells in vitro.

1997 • 157 citations

Interferon-β inhibits progression of relapsing-remitting experimental autoimmune encephalomyelitis

1996 • 153 citations

Immunology of the Nervous System

1983 • 150 citations

The human homolog of the JE gene encodes a monocyte secretory protein.

1989 • 148 citations

Distribution of Immunoglobulin Superfamily Members ICAM-1, -2, -3, and the β2 Integrin LFA-1 in Multiple Sclerosis Lesions

1996 • 146 citations

Expression and functional significance of alternatively spliced CS1 fibronectin in rheumatoid arthritis microvasculature.

1994 • 138 citations

Chemokine receptors and molecular mimicry

1994 • 133 citations

Chemokines: new ligands, receptors and activities

1995 • 121 citations

In situ demonstration of proliferating cells in the rat central nervous system during experimental autoimmune encephalomyelitis. Evidence suggesting that most infiltrating T cells do not proliferate in the target organ.

1992 • 112 citations

Chemotactic activity on mononuclear cells in the cerebrospinal fluid of patients with viral meningitis is mediated by interferon‐γ inducible protein‐10 and monocyte chemotactic protein‐1

1997 • 110 citations

Identification of RANTES receptors on human monocytic cells: competition for binding and desensitization by homologous chemotactic cytokines.

1993 • 110 citations

Inflammation in the nervous system. Basic mechanisms and immunological concepts.

1991 • 100 citations

The human erythrocyte inflammatory peptide (chemokine) receptor. Biochemical characterization, solubilization, and development of a binding assay for the soluble receptor

1993 • 99 citations

Chemokines in the Cerebrospinal Fluid of Patients with Meningitis

1996 • 95 citations

Primary sensory neurons migrate in response to the chemokine RANTES

1998 • 84 citations

Chronologic localization of myelin‐reactive cells in the lesions of relapsing EAE

1993 • 78 citations

Do Chemokines Mediate Inflammatory Cell Invasion of the Central Nervous System Parenchyma?

1994 • 68 citations

Expression of monocyte chemoattractant protein (MCP-1) and nitric oxide synthase-2 following cerebral trauma

1998 • 64 citations

Transfer of experimental allergic encephalomyelitis to bone marrow chimeras. Endothelial cells are not a restricting element.

1987 • 63 citations

Molecular piracy of chemokine receptors by herpesviruses.

1994 • 52 citations

Animal Models of Demyelination

1996 • 52 citations

Overview of Chemokines

1993 • 38 citations

CD4 and CD8 lymphocyte subsets in cerebrospinal fluid and peripheral blood from patients with multiple sclerosis, meningitis and normal controls

2009 • 34 citations

Experimental allergic encephalomyelitis. T cell trafficking to the central nervous system in a resistant Thy-1 congenic mouse strain.

1994 • 31 citations

Self-determinants in autoimmune demyelinating disease: changes in T- cell response specificity

1994 • 21 citations