Insights into the aetiology and pathogenesis of multiple sclerosis

Handbook of clinical neurology

1986 • 1,951 citations

Molecular mimicry in T cell-mediated autoimmunity: Viral peptides activate human T cell clones specific for myelin basic protein

1995 • 1,528 citations

Tumor necrosis factor mediates myelin and oligodendrocyte damage in vitro

1988 • 1,371 citations

T-cell recognition of an immuno-dominant myelin basic protein epitope in multiple sclerosis

1990 • 906 citations

HLA and Disease Associations

1985 • 893 citations

McAlpine's Multiple Sclerosis

2006 • 768 citations

Treatment of multiple sclerosis with gamma interferon

1987 • 739 citations

Augmentation of demyelination in rat acute allergic encephalomyelitis by circulating mouse monoclonal antibodies directed against a myelin/oligodendrocyte glycoprotein.

1988 • 721 citations

Increased MRI activity and immune activation in two multiple sclerosis patients treated with the monoclonal anti-tumor necrosis factor antibody cA2

1996 • 715 citations

A full genome search in multiple sclerosis

1996 • 666 citations

A complete genomic screen for multiple sclerosis underscores a role for the major histocompatability complex

1996 • 650 citations

A Population-Based Study of Multiple Sclerosis in Twins

1986 • 644 citations

A genome screen in multiple sclerosis reveals susceptibility loci on chromosome 6p21 and 17q22

1996 • 638 citations

Plaque-associated expression of human herpesvirus 6 in multiple sclerosis.

1995 • 611 citations

TNF is a potent anti-inflammatory cytokine in autoimmune-mediated demyelination

1998 • 553 citations

Increased frequency of interleukin 2-responsive T cells specific for myelin basic protein and proteolipid protein in peripheral blood and cerebrospinal fluid of patients with multiple sclerosis.

1994 • 539 citations

The epidemiology of multiple sclerosis

2016 • 505 citations

A population‐based study of multiple sclerosis in twins: Update

1993 • 420 citations

Limited heterogeneity of rearranged T-cell receptor Vα transcripts in brains of multiple sclerosis patients

1990 • 395 citations

Differential Ultrastructural Localization of Myelin Basic Protein, Myelin/Oligodendroglial Glycoprotein, and 2′,3′‐Cyclic Nucleotide 3′‐Phosphodiesterase in the CNS of Adult Rats

1989 • 388 citations

Shared Human T Cell Receptor V _β Usage to Immunodominant Regions of Myelin Basic Protein

1990 • 386 citations

Immunological Aspects of Experimental Allergic Encephalomyelitis and Multiple Sclerosis

1995 • 381 citations

YELLOW NAILS AND LYMPHOEDEMA.

1964 • 370 citations

A monoclonal antibody against a myelin oligodendrocyte glycoprotein induces relapses and demyelination in central nervous system autoimmune disease.

1987 • 368 citations

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

1990 • 363 citations

Fine specificity and HLA restriction of myelin basic protein-specific cytotoxic T cell lines from multiple sclerosis patients and healthy individuals.

1990 • 342 citations

Myelin basic protein‐specific T lymphocyte lines from MS patients and healthy individuals

1990 • 332 citations

Multiple sclerosis. Updated risks for relatives

1988 • 330 citations

A Textbook of Neuropathology

1950 • 325 citations

Structural requirements for binding of an immunodominant myelin basic protein peptide to DR2 isotypes and for its recognition by human T cell clones.

1994 • 323 citations

Reactivity to myelin antigens in multiple sclerosis. Peripheral blood lymphocytes respond predominantly to myelin oligodendrocyte glycoprotein.

1993 • 319 citations

A novel myelin-associated glycoprotein defined by a mouse monoclonal antibody

1984 • 318 citations

T and B cell responses to myelin-oligodendrocyte glycoprotein in multiple sclerosis.

1991 • 314 citations

Epidemiology of Multiple Sclerosis: A Critical Overview

1993 • 306 citations

A myelin basic protein peptide is recognized by cytotoxic T cells in the context of four HLA-DR types associated with multiple sclerosis.

1991 • 286 citations

Colocalization of lymphocytes bearing gamma delta T-cell receptor and heat shock protein hsp65+ oligodendrocytes in multiple sclerosis.

1991 • 285 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 284 citations

Interferon-gamma-induced oligodendrocyte cell death: implications for the pathogenesis of multiple sclerosis.

1995 • 283 citations

Gamma delta T-cell receptor repertoire in acute multiple sclerosis lesions.

1992 • 280 citations

Myelin oligodendrocyte glycoprotein: a novel candidate autoantigen in multiple sclerosis

1997 • 267 citations

T cells specific for the myelin oligodendrocyte glycoprotein mediate an unusual autoimmune inflammatory response in the central nervous system

1993 • 265 citations

Interferon-γ-Induced Oligodendrocyte Cell Death: Implications for the Pathogenesis of Multiple Sclerosis

1995 • 249 citations

Myelin/oligodendrocyte glycoprotein is a unique member of the immunoglobulin superfamily

1992 • 240 citations

Selective Loss of the Suppressor-Inducer T-Cell Subset in Progressive Multiple Sclerosis

1987 • 240 citations

The Epidemiology of Multiple Sclerosis

1997 • 238 citations

The N-terminal domain of the myelin oligodendrocyte glycoprotein (MOG) induces acute demyelinating experimental autoimmune encephalomyelitis in the Lewis rat

1995 • 231 citations

Pathogenesis of multiple sclerosis

1994 • 230 citations

McAlpine's Multiple Sclerosis

1991 • 211 citations

Pathology of the early lesion in multiple sclerosis

1975 • 192 citations

Myelin oligodendrocyte glycoprotein induces a demyelinating encephalomyelitis resembling multiple sclerosis.

1995 • 185 citations

Ligand motifs of HLA-DRB5*0101 and DRB1*1501 molecules delineated from self-peptides.

1994 • 179 citations

The Increased Susceptibility of Women to Multiple Sclerosis

1992 • 172 citations

Demyelination Induced in Aggregating Brain Cell Cultures by a Monoclonal Antibody Against Myelin/Oligodendrocyte Glycoprotein

1990 • 165 citations

T cell receptor V alpha-V beta repertoire and cytokine gene expression in active multiple sclerosis lesions.

1992 • 163 citations

The M2 autoantigen of central nervous system myelin, a glycoprotein present in oligodendrocyte membrane.

1986 • 151 citations

Myelin basic protein–specific T lymphocytes in multiple sclerosis and controls: Precursor frequency, fine specificity, and cytotoxicity

1992 • 149 citations

Diversity in fine specificity and T cell receptor usage of the human CD4+ cytotoxic T cell response specific for the immunodominant myelin basic protein peptide 87-106.

1992 • 148 citations

Induction of persistently demyelinated lesions in the rat following the repeated adoptive transfer of encephalitogenic T cells and demyelinating antibody

1992 • 146 citations

Myelin basic protein-specific T lymphocyte repertoire in multiple sclerosis. Complexity of the response and dominance of nested epitopes due to recruitment of multiple T cell clones.

1993 • 145 citations

CSF Antibody to Myelin Basic Protein

1980 • 144 citations

EXPERIMENTAL AUTOIMMUNE ENCEPHALO‐MYELITIS IN MICE: GENETIC CONTROL OF SUSCEPTIBILITY*

1976 • 142 citations

HLA-DQA1 and HLA-DQB1 genes may jointly determine susceptibility to develop multiple sclerosis

1991 • 140 citations

Induction of a Multiple Sclerosis-Like Disease in Mice with an Immunodominant Epitope of Myelin Oligodendrocyte Glycoprotein

1998 • 139 citations

T Helper 1 (TH1) Functional Phenotype of Human Myelin Basic Protein-Specific T Lymphocytes

1993 • 136 citations

The demyelinating potential of antibodies to myelin oligodendrocyte glycoprotein is related to their ability to fix complement

1991 • 136 citations

Epidemiology of multiple sclerosis in Australia: With NSW and SA survey results

1994 • 133 citations

MULTIPLE SCLEROSIS: A QUANTITATIVE AND QUALITATIVE STUDY OF IMMUNOGLOBULIN‐CONTAINING CELLS IN THE CENTRAL NERVOUS SYSTEM

1980 • 122 citations

Multiple sclerosis: a pivotal role for the T cell in lesion development

1991 • 118 citations

McAlpine's Multiple Sclerosis

1985 • 117 citations

Sardinian multiple sclerosis is associated with HLA‐DR4

1988 • 116 citations

Anti‐myelin basic protein and anti‐proteolipid protein specific forms of multiple sclerosis

1994 • 107 citations

Patients with multiple sclerosis carry DQB1 genes which encode shared polymorphic amino acid sequences

1989 • 97 citations

HL-A Antigen Frequencies in Multiple Sclerosis

1972 • 96 citations

Studies on autoimmune encephalomyelitis in the guinea pig. II. An in vitro investigation on the nature, properties, and specificity of the serum-demyelinating factor.

1976 • 92 citations

γδ T cell receptor repertoire in brain lesions of patients with multiple sclerosis

1993 • 89 citations

Occurrence of multiple sclerosis in the north and south of New Zealand.

1987 • 88 citations

Parent‐child concordance in multiple sclerosis

1991 • 86 citations

Diversity of T cell receptor α and β chain genes expressed by human T cells specific for similar myelin basic protein peptide/major histocompatibility complexes

1992 • 82 citations

The distribution of multiple sclerosis in the United Kingdom.

1986 • 76 citations

Multiple sclerosis in a nationwide series of twins

1987 • 69 citations

Immunology of multiple sclerosis.

1992 • 64 citations

Frontiers in Multiple Sclerosis

1998 • 63 citations

The germline repertoire of T-cell receptor ? chain genes in patients with relapsing/remitting multiple sclerosis or optic neuritis

1990 • 61 citations

Multiple Sclerosis. Pathology, Diagnosis and Management.

1983 • 58 citations

McAlpine's Multiple Sclerosis, 2nd Ed.

1991 • 57 citations

STUDIES ON THE CLUSTERING OF MULTIPLE SCLEROSIS IN FINLAND II: MICROEPIDEMIOLOGY IN ONE HIGH-RISK COUNTY WITH SPECIAL REFERENCE TO FAMILIAL CASES

1975 • 54 citations

[Clinical aspects of multiple sclerosis].

1968 • 54 citations

Multiple sclerosis sibling pairs

1990 • 52 citations

HLA‐DR‐restricted presentation of purified myelin basic protein is independent of intracellular processing

1997 • 49 citations

Analysis of the fine B cell specificity during the chronic/relapsing course of a multiple sclerosis-like disease in Lewis rats injected with the encephalitogenic myelin oligodendrocyte glycoprotein peptide 35-55.

1996 • 47 citations

Homologies between T cell receptor junctional sequences unique to multiple sclerosis and T cells mediating experimental allergic encephalomyelitis.

1994 • 46 citations

The social epidemiology of multiple sclerosis

1990 • 37 citations

The clinical profile of MS in Australia

1988 • 35 citations

Experimental Models of Human Autoimmune Disease: Overview and Prototypes

1992 • 35 citations

Preparation of highly purified human myelin oligodendrocyte glycoprotein in quantities sufficient for encephalitogenicity and immunogenicity studies.

1993 • 34 citations

Neurology

1985 • 34 citations

Antibody response in Lewis rats injected with myelin oligodendrocyte glycoprotein derived peptides

1996 • 33 citations

Canine distemper virus-specific antibodies in multiple sclerosis

1995 • 29 citations

An allelic cluster of DQα restriction fragments is associated with multiple sclerosis: Evidence that a second haplotype may influence disease susceptibility

1989 • 29 citations

Cellular and molecular mechanisms of autoimmune demyelination in the central nervous system.

1989 • 27 citations

Multiple sclerosis: immunological findings and possible implications for therapy

1992 • 26 citations

New insights into the immunogenetics of multiple sclerosis

1997 • 25 citations

Multiple Sclerosis: Pathology, Diagnosis and Management

1984 • 24 citations

TCR repertoire to proteolipid protein (PLP) in multiple sclerosis (MS): homologies between PLP-specific T cells and MS-associated T cells in TCR junctional sequences

1996 • 23 citations

Influence of HLA-DR2, HLA-DPw4, and T cell receptor α chain genes on the susceptibility to multiple sclerosis

1992 • 19 citations

Do antibodies to myelin basic protein isolated from multiple sclerosis cross-react with measles and other common virus antigens?

1983 • 18 citations

Multiple sclerosis

1988 • 17 citations

Clinical Neuroimmunology

1988 • 15 citations

Multiple Sclerosis: Multiple Etiologies, Multiple Genes?

1994 • 15 citations

Textbook of Neuropathology.

1991 • 14 citations

Studies on the clustering of multiple sclerosis in Finland.

1976 • 10 citations

Studies on autoimmune encephalomyelitis in the guinea pig IV. Relative independence of acute and chronic diseases

1981 • 8 citations

Association of HLA and multiple sclerosis.

1994 • 4 citations

Deleted Work

1955 • 0 citations