Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats

Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.

1983 • 1,918 citations

Protein damage and degradation by oxygen radicals. I. general aspects.

1987 • 1,618 citations

The Heterogeneity of Mononuclear Phagocytes in Lymphoid Organs: Distinct Macrophage Subpopulations in Rat Recognized by Monoclonal Antibodies ED1, ED2 and ED3

1985 • 1,605 citations

A simple colorimetric method for the measurement of hydrogen peroxide produced by cells in culture

1980 • 1,180 citations

Cytotoxicity of microglia

1993 • 1,042 citations

Oxidants from phagocytes: agents of defense and destruction

1984 • 803 citations

Comparison of in vitro cell cytotoxic assays for tumor necrosis factor

1984 • 752 citations

An antibody to lymphotoxin and tumor necrosis factor prevents transfer of experimental allergic encephalomyelitis.

1990 • 692 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Production of superoxide anions by a CNS macrophage, the microglia

1987 • 619 citations

Priming of neutrophils for enhanced release of oxygen metabolites by bacterial lipopolysaccharide. Evidence for increased activity of the superoxide-producing enzyme.

1984 • 612 citations

Role of hydrogen peroxide in neutrophil-mediated destruction of cultured endothelial cells.

1981 • 587 citations

Rat macrophage lysosomal membrane antigen recognized by monoclonal antibody ED1.

1994 • 517 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

Anti—tumor necrosis factor therapy abrogates autoimmune demyelination

1991 • 434 citations

Free Radicals as Mediators of Tissue Injury

1991 • 386 citations

Oxygen Radicals in Biology and Medicine

1988 • 293 citations

Enhancement of neutrophil superoxide production by preincubation with recombinant human tumor necrosis factor.

1987 • 292 citations

Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.

1986 • 231 citations

The distribution of Ia antigen in the lesions of rat acute experimental allergic encephalomyelitis

1986 • 214 citations

Immunohistochemical analysis of the rat central nervous system during experimental allergic encephalomyelitis, with special reference to Ia-positive cells with dendritic morphology.

1986 • 204 citations

Phagocytic activity of macrophages and microglial cells during the course of acute and chronic relapsing experimental autoimmune encephalomyelitis

1994 • 202 citations

Microglial and astroglial reactions to inflammatory lesions of experimental autoimmune encephalomyelitis in the rat central nervous system

1992 • 174 citations

Effect of Reactive Oxygen Species on Myelin Membrane Proteins

1985 • 153 citations

Elevated secretion of reactive nitrogen and oxygen intermediates by inflammatory leukocytes in hyperacute experimental autoimmune encephalomyelitis: enhancement by the soluble products of encephalitogenic T cells.

1992 • 136 citations

Heterogeneity of Macrophages in the Rat Evidenced by Variability in Determinants: Two New Anti-Rat Macrophage Antibodies Against a Heterodimer of 160 and 95 kd (CD11/CD18)

1989 • 130 citations

Immunohistological analysis of macrophages in the central nervous system of Lewis rats with acute experimental allergic encephalomyelitis

1986 • 102 citations

Oligodendroglial cell death induced by oxygen radicals and its protection by catalase

1991 • 101 citations

Treatment with anti‐CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rats

1993 • 96 citations

Suppression of experimental autoimmune neuritis by the oxygen radical scavengers superoxide dismutase and catalase

1988 • 91 citations

COMPARISON BETWEEN LUMINOL- AND LUCIGENINDEPENDENT CHEMILUMINESCENCE OF POLYMORPHONUCLEAR LEUKOCYTES

2009 • 61 citations

Monocyte and polymorphonuclear leukocyte toxic oxygen metabolite production in multiple sclerosis

1988 • 47 citations

Central nervous system endothelial cell-polymorphonuclear cell interactions during autoimmune demyelination.

1991 • 41 citations

Observer agreement in the assessment of clinical signs in experimental allergic encephalomyelitis

1989 • 24 citations

Monocytes Constitute the Only Peripheral Blood Cell Population Showing an Increased Burst Activity in Multiple Sclerosis Patients

1986 • 21 citations

Oxygen Radical-Mediated Damage to Brain Tissue

1988 • 13 citations

Proteolytic and peroxidatic reactions of commercial horseradish peroxidase with myelin basic protein

1978 • 12 citations

The Significance of in-situ Ia Antigen Expression in the Pathogenesis of Autoimmune Central Nervous System Disease

1993 • 9 citations

Separation of Human Lymphocytes on the Basis of Volume and Density

1979 • 8 citations

Evidence that superoxide-anion, produced by PMA-activated human polymorphonuclear leukocytes, is the cytolytic agent for rabbit, but not for sheep red blood cells

1988 • 5 citations

Analysis of the antigen-induced in vitro differentiation of human peripheral blood B cells: stimulation with ovalbumin induces the transition from the resting state into the excited state.

1985 • 5 citations