Discordant effects of anti–VLA-4 treatment before and after onset of relapsing experimental autoimmune encephalomyelitis

Prevention of experimental autoimmune encephalomyelitis by antibodies against α4βl integrin

1992 • 1,711 citations

α4β7 integrin mediates lymphocyte binding to the mucosal vascular addressin MAdCAM-1

1993 • 1,427 citations

Surface expression of alpha 4 integrin by CD4 T cells is required for their entry into brain parenchyma.

1993 • 837 citations

Matrix metalloproteinases and diseases of the CNS

1998 • 646 citations

Analysis of cytokine mRNA expression in the central nervous system of mice with experimental autoimmune encephalomyelitis reveals that IL-10 mRNA expression correlates with recovery.

1992 • 627 citations

Functional evidence for epitope spreading in the relapsing pathology of experimental autoimmune encephalomyelitis.

1995 • 522 citations

Determinant spreading and the dynamics of the autoimmune T-cell repertoire

1993 • 467 citations

Costimulation of proliferative responses of resting CD4+ T cells by the interaction of VLA-4 and VLA-5 with fibronectin or VLA-6 with laminin.

1990 • 400 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

The effect of anti-α4 integrin antibody on brain lesion activity in MS

1999 • 305 citations

Analysis of T cell stimulation by superantigen plus major histocompatibility complex class II molecules or by CD3 monoclonal antibody: costimulation by purified adhesion ligands VCAM-1, ICAM-1, but not ELAM-1.

1991 • 293 citations

Antibodies to CD44 and integrin α₄, but not L-selectin, prevent central nervous system inflammation and experimental encephalomyelitis by blocking secondary leukocyte recruitment

1999 • 287 citations

Cytokines and adhesion molecules contribute to the ability of myelin proteolipid protein-specific T cell clones to mediate experimental allergic encephalomyelitis.

1993 • 277 citations

Induction of active and adoptive relapsing experimental autoimmune encephalomyelitis (EAE) using an encephalitogenic epitope of proteolipid protein

1992 • 231 citations

Differential adhesion molecule requirements for immune surveillance and inflammatory recruitment

2000 • 218 citations

Pathologic Role and Temporal Appearance of Newly Emerging Autoepitopes in Relapsing Experimental Autoimmune Encephalomyelitis

2000 • 212 citations

Selective, Tight-Binding Inhibitors of Integrin α4β1 That Inhibit Allergic Airway Responses

1999 • 207 citations

Differential Expression of Inflammatory Cytokines Parallels Progression of Central Nervous System Pathology in Two Clinically Distinct Models of Multiple Sclerosis

1998 • 200 citations

Relapsing experimental allergic encephalomyelitis in the SJL/J mouse.

1981 • 197 citations

Adhesion molecules in autoimmune disease

1996 • 194 citations

The functional significance of epitope spreading and its regulation by co‐stimulatory molecules

1998 • 162 citations

Fibronectin interaction with α4β1 integrin prevents apoptosis in B cell chronic lymphocytic leukemia: correlation with Bcl-2 and Bax

1999 • 139 citations

Experimental allergic encephalomyelitis mediated by cloned T cells specific for a synthetic peptide of myelin proteolipid protein. Fine specificity and T cell receptor V beta usage.

1992 • 135 citations

In situ expression of the cell adhesion molecules in bronchial tissues from asthmatics with air flow limitation: in vivo evidence of VCAM-1/VLA-4 interaction in selective eosinophil infiltration.

1995 • 123 citations

Humanization of a mouse antibody against human alpha-4 integrin: A potential therapeutic for the treatment of multiple sclerosis

1997 • 118 citations

Role of the VLA-4 molecule in T cell costimulation. Identification of the tyrosine phosphorylation pattern induced by the ligation of VLA-4.

1995 • 118 citations

Regulation of lymphocyte homing into the brain during viral encephalitis at various stages of infection.

1996 • 97 citations

The roles of adhesion molecules and proteinases in lymphocyte transendothelial migration

1996 • 89 citations

β7 integrins contribute to demyelinating disease of the central nervous system

2000 • 89 citations

Human skin mast cells express functional beta 1 integrins that mediate adhesion to extracellular matrix proteins.

1995 • 67 citations

Rescue from apoptosis in early (CD34-selected) versus late (non-CD34-selected) human hematopoietic cells by very late antigen 4- and vascular cell adhesion molecule (VCAM) 1-dependent adhesion to bone marrow stromal cells.

1998 • 54 citations

Treatment with intact anti-B7-1 mAb during disease remission enhances epitope spreading and exacerbates relapses in R-EAE

1997 • 47 citations

A monoclonal antibody to α4‐integrin reverses the MR‐detectable signs of experimental allergic encephalomyelitis in the Guinea pig

1995 • 38 citations

Administration of Monoclonal Antibodies against Vascular Cell Adhesion Molecule-1/Very Late Antigen-4 Abrogates Predisposing Autoimmune Diabetes in NOD Mice

1995 • 34 citations

Adhesion molecules mediating neutrophil migration to arthritis in vivo and across endothelium and connective tissue barriers in vitro

1998 • 34 citations

Specific Immunosuppression of Corneal Allograft Rejection by Combination of Anti-VLA-4 and Anti-LFA-1 Monoclonal Antibodies in Mice

1997 • 34 citations

Pediatric AIDS-Associated Lymphocytic Interstitial Pneumonia and Pulmonary Arterio-Occlusive Disease

1999 • 29 citations

Co-ligation of alpha4beta1 integrin and TCR rescues human thymocytes from steroid-induced apoptosis

1998 • 25 citations

A role for the VLA‐4 integrin in the activation of human memory B cells

1997 • 24 citations

Adhesion and costimulation of proliferative responses of human γδ T cells by interaction of VLA-4 and VLA-5 with fibronectin

1993 • 17 citations

Anti VLA-4 monoclonal antibody inhibits eosinophil infiltration in allergic conjunctivitis model of guinea pig

1999 • 17 citations

Blockade of α4β1-Integrin–Fibronectin Adhesive Interactions Prevents Chronic Allograft Rejection in Sensitized Recipients

1998 • 8 citations

The role of adhesion molecules in allotransplanted islet cells rejection. Prolongation of islet cells allograft survival by antiadhesion treatment.

1998 • 3 citations