Immune Invasion of the Central Nervous System Parenchyma and Experimental Allergic Encephalomyelitis, But Not Leukocyte Extravasation from Blood, Are Prevented in Macrophage-Depleted Mice

F4/80, a monoclonal antibody directed specifically against the mouse macrophage

1981 • 1,582 citations

Perivascular Microglial Cells of the CNS Are Bone Marrow-Derived and Present Antigen in Vivo

1988 • 1,451 citations

Immunological Aspects of Demyelinating Diseases

1992 • 1,021 citations

High level IL-12 production by murine dendritic cells: upregulation via MHC class II and CD40 molecules and downregulation by IL-4 and IL-10.

1996 • 959 citations

A B-cell-homing chemokine made in lymphoid follicles activates Burkitt's lymphoma receptor-1

1998 • 810 citations

B Cell–attracting Chemokine 1, a Human CXC Chemokine Expressed in Lymphoid Tissues, Selectively Attracts B Lymphocytes via BLR1/CXCR5

1998 • 807 citations

Cellular immune reactivity within the CNS

1986 • 771 citations

Macrophages and microglia in the nervous system

1988 • 742 citations

Cytokines in inflammatory brain lesions: helpful and harmful

1996 • 727 citations

Isolation and direct characterization of resident microglial cells from the normal and inflamed central nervous system.

1991 • 675 citations

Suppression of experimental allergic encephalomyelitis in Lewis rats after elimination of macrophages.

1990 • 511 citations

CD40-CD40 ligand interactions in experimental allergic encephalomyelitis and multiple sclerosis.

1996 • 492 citations

An important role for the chemokine macrophage inflammatory protein-1 alpha in the pathogenesis of the T cell-mediated autoimmune disease, experimental autoimmune encephalomyelitis.

1995 • 487 citations

Expression of costimulatory molecules B7-1 (CD80), B7-2 (CD86), and interleukin 12 cytokine in multiple sclerosis lesions.

1995 • 473 citations

Biology of disease. Analysis of autoimmune demyelination: its impact upon multiple sclerosis.

1984 • 424 citations

TNF-alpha expression by resident microglia and infiltrating leukocytes in the central nervous system of mice with experimental allergic encephalomyelitis. Regulation by Th1 cytokines.

1995 • 401 citations

Controlled recruitment of monocytes and macrophages to specific organs through transgenic expression of monocyte chemoattractant protein-1.

1995 • 389 citations

Chemokine expression in murine experimental allergic encephalomyelitis

1995 • 363 citations

Reversal of experimental autoimmune encephalomyelitis with a hydroxamate inhibitor of matrix metalloproteases.

1994 • 338 citations

Blockade of CD28/B7-1 interaction prevents epitope spreading and clinical relapses of murine EAE

1995 • 326 citations

Antigens displayed on murine B lymphocyte precursors.

1981 • 299 citations

Synchronous synthesis of alpha- and beta-chemokines by cells of diverse lineage in the central nervous system of mice with relapses of chronic experimental autoimmune encephalomyelitis.

1997 • 284 citations

Transfer of diabetes in mice prevented by blockade of adhesion-promoting receptor on macrophages

1990 • 245 citations

Marginal metallophilic cells of the mouse spleen identified by a monoclonal antibody.

1986 • 231 citations

The role of macrophages, perivascular cells, and microglial cells in the pathogenesis of experimental autoimmune encephalomyelitis

1995 • 213 citations

Matrix metalloproteinase expression during experimental autoimmune encephalomyelitis and effects of a combined matrix metalloproteinase and tumour necrosis factor-α inhibitor

1997 • 205 citations

Experimental autoimmune encephalomyelitis: the antigen specificity of T lymphocytes determines the topography of lesions in the central and peripheral nervous system.

1997 • 190 citations

Experimental allergic encephalomyelitis in the absence of a classical delayed-type hypersensitivity reaction. Severe paralytic disease correlates with the presence of interleukin 2 receptor-positive cells infiltrating the central nervous system.

1987 • 182 citations

Expression of the inducible isoform of nitric oxide synthase in the central nervous system of mice correlates with the severity of actively induced experimental allergic encephalomyelitis

1995 • 181 citations

Inflammatory cytokines in the brain: Does the CNS shape immune responses?

1994 • 180 citations

Cytokine production in the central nervous system of Lewis rats with experimental autoimmune encephalomyelitis: dynamics of mRNA expression for interleukin-10, interleukin-12, cytolysin, tumor necrosis factor α and tumor necrosis factor β

1995 • 179 citations

Transgenic tumor necrosis factor (TNF)-alpha production in pancreatic islets leads to insulitis, not diabetes. Distinct patterns of inflammation in TNF-alpha and TNF-beta transgenic mice.

1993 • 169 citations

Reactive oxygen species are involved in the pathogenesis of experimental allergic encephalomyelitis in Lewis rats

1995 • 156 citations

The Immunology of Multiple Sclerosis and its Animal Model, Experimental Allergic Encephalomyelitis

1995 • 146 citations

Astrocytes and microglia express inducible nitric oxide synthase in mice with experimental allergic encephalomyelitis

1997 • 137 citations

Anti-macrophage CR3 antibody blocks myelin phagocytosis by macrophages in vitro

1990 • 134 citations

Determination of the origin and nature of brain macrophages and microglial cells in mouse central nervous system, using non‐radioactive in situ hybridization and immunoperoxidase techniques

1992 • 122 citations

Demonstration of interleukin-1β in Lewis rat brain during experimental allergic encephalomyelitis by immunocytochemistry at the light and ultrastructural level

1993 • 119 citations

Effect of liposome-mediated macrophage depletion on LPS-induced cytokine gene expression and radioprotection.

1995 • 117 citations

Transient suppression of macrophage functions by liposome-encapsulated drugs

1997 • 116 citations

Macrophages in T cell line-mediated, demyelinating, and chronic relapsing experimental autoimmune encephalomyelitis in Lewis rats

1995 • 113 citations

The central nervous system environment controls effector CD4⁺ T cell cytokine profile in experimental allergic encephalomyelitis

1997 • 106 citations

Glutamate metabolism is down-regulated in astrocytes during experimental allergic encephalomyelitis

1997 • 102 citations

Marginal zone macrophages in the mouse spleen identified by a monoclonal antibody. Anatomical correlation with a B cell subpopulation.

1985 • 97 citations

Treatment with anti‐CR3 antibodies ED7 and ED8 suppresses experimental allergic encephalomyelitis in Lewis rats

1993 • 96 citations

Direct demonstration of the infiltration of murine central nervous system by Pgp-1/CD44high CD45RBlow CD4+ T cells that induce experimental allergic encephalomyelitis

1992 • 91 citations

Inhibition of leukotriene B4-receptor interaction suppresses eosinophil infiltration and disease pathology in a murine model of experimental allergic encephalomyelitis.

1996 • 84 citations

Unimpaired autoreactive T-cell traffic within the central nervous system during tumor necrosis factor receptor-mediated inhibition of experimental autoimmune encephalomyelitis.

1995 • 66 citations

Liposome Mediated Affection of Monocytes

1992 • 60 citations

IL-12 expression in AIDS-related lymphoma B cell lines.

1996 • 56 citations

Normal B cells fail to secrete interleukin-12

1997 • 52 citations

NMR investigation of the charge isomers of bovine myelin basic protein

1984 • 41 citations

T cell priming against vesicular stomatitis virus analyzed in situ: red pulp macrophages, but neither marginal metallophilic nor marginal zone macrophages, are required for priming CD4+ and CD8+ T cells.

1997 • 39 citations

Immunoregulation of passively induced allergic encephalomyelitis.

1986 • 36 citations