Infrequent Ha‐ras mutations and absence of Ki‐ras, N‐ras, and p53 mutations in 4‐nitroquinoline 1‐oxide‐induced rat oral lesions

Rapid and sensitive detection of point mutations and DNA polymorphisms using the polymerase chain reaction

1989 • 3,557 citations

“Field cancerization” in oral stratified squamous epithelium. Clinical implications of multicentric origin

1953 • 3,421 citations

Smoking and drinking in relation to oral and pharyngeal cancer.

1988 • 1,962 citations

Generation of single-stranded DNA by the polymerase chain reaction and its application to direct sequencing of the HLA-DQA locus.

1988 • 1,582 citations

Carcinogen-specific mutation and amplification of Ha-ras during mouse skin carcinogenesis

1986 • 865 citations

The incidence of p53 mutations increases with progression of head and neck cancer.

1993 • 602 citations

Inhibition of 4-nitroquinoline-1-oxide-induced rat tongue carcinogenesis by the naturally occurring plant phenolics caffeic, ellagic, chlorogenic and ferulic acids

1993 • 336 citations

BILATERAL ZOSTER

1947 • 322 citations

Frequent p53 mutations in head and neck cancer.

1992 • 287 citations

NUTRITIONAL MUSCULAR DYSTROPHY AND HUMAN MYOCARDIAL INFARCTION

1973 • 280 citations

Carcinogen-induced mutations in the mouse c-Ha-ras gene provide evidence of multiple pathways for tumor progression.

1990 • 270 citations

High frequency mutation in codons 12 and 61 of H-ras oncogene in chewing tobacco-related human oral carcinoma in India

1991 • 241 citations

Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract.

1993 • 241 citations

Most human squamous cell carcinomas in the oral cavity contain mutated p53 tumor-suppressor genes.

1992 • 237 citations

Occurrence of epithelial dysplasia in oral leukoplakia

1976 • 226 citations

p53 mutation and protein accumulation during multistage human esophageal carcinogenesis.

1992 • 198 citations

Genetic analysis of human esophageal tumors from two high incidence geographic areas: frequent p53 base substitutions and absence of ras mutations.

1991 • 196 citations

Carcinogenic action of 4-nitroquinoline-N-oxide.

1957 • 175 citations

Oncogenes and tumour-suppressor genes in squamous cell carcinoma of the head and neck

1992 • 165 citations

Allele-specific polymerase chain reaction: A method for amplification and sequence determination of a single component among a mixture of sequence variants

1991 • 163 citations

Molecular Biology of the Carcinogen, 4-Nitroquinoline 1-Oxide

1976 • 130 citations

A simple method for amplification of DNA from paraffin-embedded tissues

1992 • 121 citations

Low incidence of ras oncogene activation in human squamous cell carcinomas

1990 • 98 citations

Structure of the rat p53 tumor suppressor gene

1993 • 86 citations

Chemoprevention of 4-nitroquinoline 1-oxide-induced oral carcinogenesis by dietary protocatechuic acid during initiation and postinitiation phases.

1994 • 85 citations

Formation of 8-hydroxyguanine residues in cellular DNA exposed to the carcinogen 4-nitroquinoline 1-oxide

1986 • 81 citations

Nucleotide sequence of the two rat cellular rasH genes.

1986 • 75 citations

Molecular Basis of 4‐Nitroquinoline 1‐Oxide Carcinogenesis

1989 • 69 citations

Adducts from in vivo action of the carcinogen 4-hydroxyaminoquinoline 1-oxide in rats and from in vitro reaction of 4-acetoxyaminoquinoline 1-oxide with DNA and polynucleotides.

1985 • 69 citations

Specific induction of transitions and transversions of G · C base pairs by 4-nitroquinoline-1-oxide in iso-1-cytochrome c mutants of yeast

1974 • 59 citations

Structure of the c-Ki-ras Gene in a Rat Fibrosarcoma Induced by 1,8-Dinitropyrene

1986 • 53 citations

ras Gene point mutation is a rare event in premalignant tissues and malignant cells and tissues from oral mucosal lesions

1993 • 46 citations

Infrequent mutation of ha‐ras and p53 in rat mammary carcinomas induced by 2‐amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1994 • 45 citations

Harvey ras (H-ras) point mutations are induced by 4-nitroquinoline-1-oxide in murine oral squamous epithelia, while squamous cell carcinomas and loss of heterozygosity occur without additional exposure.

1994 • 43 citations

Rare frequency of activation of the ki‐ras gene in rat colon tumors induced by heterocyclic amines: Possible alternative mechanisms of human colon carcinogenesis

1993 • 40 citations

Absence of p53 Mutations in Rat Colon Tumors Induced by 2‐Amino‐6‐methyldipyrido[1,2‐a:3′, 2′‐d]imidazole, 2‐Amino‐3‐methylimidazo[4,5‐f]quinoline, or 2‐Amino‐1‐methyl‐6‐phenylimidazo[4,5‐b]pyridine

1994 • 39 citations

Alterations of the nucleolar organizer regions during 4-mtroquinoline 1-oxide-induced tongue carcinogenesis in rats

1991 • 37 citations

N2-guanyl and N6-adenyl arylation of chicken erythrocyte DNA by the ultimate carcinogen of 4-nitroquinoline 1-oxide.

1986 • 36 citations

Structure of the c-Ki-ras gene in a rat fibrosarcoma induced by 1,8-dinitropyrene.

1986 • 35 citations

Chemoprevention of oral carcinogenesis by DL-alpha-difluoromethylornithine, an ornithine decarboxylase inhibitor: dose-dependent reduction in 4-nitroquinoline 1-oxide-induced tongue neoplasms in rats.

1993 • 34 citations

Oral epithelial atypia and acantholytic dyskeratosis in rats painted with 4-nitroquinoline N-oxide

1986 • 31 citations

Activating mutation of the Ha‐ras gene in chemically induced tumors of the hamster cheek pouch

1992 • 30 citations

Chemical induction of oncogene mutations and growth factor activity in mouse skin carcinogenesis.

1989 • 26 citations

Chemical structure of QAII, one of the covalently bound adducts of carcinogenic 4-nitroquinoline 1-oxide with nucleic acid bases of cellular nucleic acids.

1975 • 24 citations

No involvement of Ki‐ras or p53 gene mutations in colitis‐associated rat colon tumors induced by 1‐hydroxyanthraquinone and methylazoxymethanol acetate

1995 • 23 citations

Oral cancer and precancer: background, epidemiology and aetiology

1989 • 20 citations

Epithelial Lesions Antedating Oesophageal Carcinoma

1983 • 20 citations

Low Incidence of Point Mutation at Codon 12 of K-Ras Proto-Oncogene in Squamous Cell Carcinoma of the Upper Aerodigestive Tract

1991 • 19 citations

Carcinogenicity of Betel Quid. III. Enhancement of 4-Nitroquinoline-1-oxide- and N-2-Fluorenylacetamide-lnduced Carcinogenesis in Rats by Subsequent Administration of Betel Nut

1986 • 18 citations

Characterization of malignant rat keratinocytes in culture following the induction of oral squamous cell carcinomas in vivo

1986 • 17 citations

Prevalence of p53 mutations in patients with squamous cell carcinoma of the esophagus

1994 • 13 citations

The rat N-ras gene; interference of pseudogenes with the detection of activating point mutations

1994 • 9 citations

Chemical Induction of Oncogene Mutations and Growth Factor Activity in Mouse Skin Carcinogenesis

1989 • 7 citations