Ceramide Synthase and Ceramidases in the Regulation of Sphingoid Base Metabolism

Biochemistry of Lipids, Lipoproteins and Membranes

2021 • 1,420 citations

Sphingosine inhibition of protein kinase C activity and of phorbol dibutyrate binding in vitro and in human platelets.

1986 • 1,150 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Handbook of lipid research

1978 • 978 citations

Sphingosine-1-phosphate as second messenger in cell proliferation induced by PDGF and FCS mitogens

1993 • 879 citations

Sphingolipid metabolism and cell growth regulation

1996 • 709 citations

Structure elucidation of the fumonisins, mycotoxins from Fusarium moniliforme

1988 • 613 citations

Ceramide: an intracellular signal for apoptosis

1995 • 604 citations

Serine Palmitoyltransferase Is the Primary Target of a Sphingosine-like Immunosuppressant, ISP-1/Myriocin

1995 • 537 citations

Role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin D3-induced HL-60 cell differentiation.

1990 • 476 citations

Intracellular Calcium Release Mediated by Sphingosine Derivatives Generated in Cells

1990 • 391 citations

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

1993 • 363 citations

Bcl-2 interrupts the ceramide-mediated pathway of cell death.

1996 • 302 citations

Fumonisins: History, World-Wide Occurrence and Impact

1996 • 249 citations

Increases in Serum Sphingosine and Sphinganine and Decreases in Complex Sphingolipids in Ponies Given Feed Containing Fumonisins, Mycotoxins Produced by Fusarium moniliforme

1992 • 223 citations

Differential Regulation of Sphingomyelinase and Ceramidase Activities by Growth Factors and Cytokines

1995 • 222 citations

(1S,2R)-D-erythro-2-(N-Myristoylamino)-1-phenyl-1-propanol as an Inhibitor of Ceramidase

1996 • 216 citations

Hierarchy of mechanisms involved in generating Na/K-ATPase polarity in MDCK epithelial cells.

1995 • 211 citations

Ceramide synthesis enhances transport of GPI-anchored proteins to the Golgi apparatus in yeast.

1994 • 210 citations

Purification, Characterization, and Biosynthesis of Human Acid Ceramidase

1995 • 209 citations

Fumonisin inhibition of de Novo sphingolipid biosynthesis and cytotoxicity are correlated in LLC-PK1 cells

1992 • 198 citations

Evidence for disruption of sphingolipid metabolism as a contributing factor in the toxicity and carcinogenicity of fumonisins

1996 • 195 citations

Enzymic Hydrolysis and Synthesis of Ceramides

1963 • 191 citations

Ceramidase and ceramide synthesis in human kidney and cerebellum

1975 • 183 citations

The long-chain sphingoid base of sphingolipids is acylated at the cytosolic surface of the endoplasmic reticulum in rat liver

1993 • 180 citations

Fumonisins and Alternaria alternata lycopersici toxins: sphinganine analog mycotoxins induce apoptosis in monkey kidney cells.

1996 • 179 citations

Specificity in Ceramide Biosynthesis from Long Chain Bases and Various Fatty Acyl Coenzyme A's by Brain Microsomes

1970 • 176 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

Fumonisins and other inhibitors of de novo sphingolipid biosynthesis.

1993 • 163 citations

The Discovery of Australifungin, a Novel Inhibitor of Sphinganine N-Acyltransferase from Sporormiella australis. Producing Organism, Fermentation, Isolation, and Biological Activity.

1995 • 161 citations

Fumonisins: fungal toxins that shed light on sphingolipid function

1996 • 150 citations

Disruption of sphingolipid metabolism and stimulation of DNA synthesis by fumonisin B1. A molecular mechanism for carcinogenesis associated with Fusarium moniliforme.

1994 • 147 citations

Biosynthesis of long-chain (sphingoid) bases from serine by LM cells. Evidence for introduction of the 4-trans-double bond after de novo biosynthesis of N-acylsphinganine(s).

1986 • 145 citations

Biosynthesis of sphingolipids: Dihydroceramide and not sphinganine is desaturated by cultured cells

1992 • 144 citations

Liquid Chromatographic Determination of Sphmgamne and Sphingosine: Use of the Free Sphinganine-to-Sphingosine Ratio as a Biomarker for Consumption of Fumonisins

1994 • 136 citations

Differential Roles of de Novo Sphingolipid Biosynthesis and Turnover in the “Burst” of Free Sphingosine and Sphinganine, and Their 1-Phosphates and N-Acyl-Derivatives, That Occurs upon Changing the Medium of Cells in Culture

1995 • 135 citations

Ceramide Inhibits Phospholipase D in a Cell-free System

1996 • 129 citations

Apoptotic and anti-proliferative effects of fumonisin B₁ in human keratinocytes, fibroblasts, esophageal epithelial cells and hepatoma cells

1996 • 121 citations

Ceramide-mediated biology. Determination of structural and stereospecific requirements through the use of N-acyl-phenylaminoalcohol analogs.

1992 • 121 citations

Enzymatic synthesis of ceramide

1966 • 120 citations

A stereoselective synthesis of sphingosine, a protein kinase c inhibitor.

1988 • 119 citations

Sphingolipid Biosynthesis de Novo by Rat Hepatocytes in Culture.

1995 • 117 citations

Regulation of Lipid Biosynthesis in Saccharomyces cerevisiae by Fumonisin B1

1995 • 111 citations

Phytotoxins. II. Characterization of a phytotoxic fraction from alternaria alternata f. sp. lycopersici

1981 • 109 citations

Free Sphingosine Formation from Endogenous Substrates by a Liver Plasma Membrane System with a Divalent Cation Dependence and a Neutral pH Optimum

1989 • 102 citations

Modulation of the free sphingosine levels in human neutrophils by phorbol esters and other factors.

1988 • 97 citations

Effects of selected secondary metabolites of Fusarium moniliforme on unscheduled synthesis of DNA by rat primary hepatocytes

1992 • 91 citations

Regulation of Cytochrome P450 2C11 (CYP2C11) Gene Expression by Interleukin-1, Sphingomyelin Hydrolysis, and Ceramides in Rat Hepatocytes

1995 • 90 citations

Suppression of Bcl‐2 gene expression by sphingosine in the apoptosis of human leukemic HL‐60 cells during phorbol ester‐induced terminal differentiation

1996 • 81 citations

Enzymatic formation of hydroxy ceramides and comparison with enzymes forming nonhydroxy ceramides

1972 • 79 citations

Stereospecificity of sphingosine-induced intracellular calcium mobilization and cellular proliferation.

1994 • 76 citations

Fumonisin B1 Alters Sphingolipid Metabolism and Disrupts the Barrier Function of Endothelial Cells in Culture

1995 • 75 citations

Mechanism of Fumonisin Toxicity and Carcinogenesis

1994 • 74 citations

Sphingolipid Biosynthesis Is Necessary for Dendrite Growth and Survival of Cerebellar Purkinje Cells in Culture

1995 • 73 citations

Repression of protein kinase C and stimulation of cyclic AMP response elements by fumonisin, a fungal encoded toxin which is a carcinogen.

1995 • 64 citations

Acid and alkaline ceramidases of rat tissues

1986 • 57 citations

Inhibition of Protein Serine/Threonine Phosphatases by Fumonisin B1, a Mycotoxin

1996 • 57 citations

Interaction of 14C-labelled fumonisin B mycotoxins with primary rat hepatocyte cultures

1994 • 54 citations

Inhibition of sphingolipid synthesis: effects on glycosphingolipid— GPI-anchored protein microdomains

1995 • 51 citations

Mechanism of Fumonisin Toxicity and Carcinogenesis

1994 • 51 citations

Sphingolipids as mediators of effects of platelet-derived growth factor in vascular smooth muscle cells

1993 • 51 citations

Intracellular transport of ceramide and its metabolites at the Golgi complex: insights from short-chain analogs.

1993 • 46 citations

Sphingosine kinase: properties and cellular functions.

1993 • 46 citations

Sphingolipid deficiency induces hypersensitivity of CD14, a glycosyl phosphatidylinositol-anchored protein, to phosphatidylinositol-specific phospholipase C

1993 • 42 citations

Mitoinhibitory effect of fumonisin B₁ on rat hepatocytes in primary culture

1995 • 42 citations

Stereoselectivity of Induction of the Retinoblastoma Gene Product (pRb) Dephosphorylation by D-erythro-Sphingosine Supports a Role for pRb in Growth Suppression by Sphingosine

1995 • 42 citations

Ceramidases: enzymology and metabolic roles.

1993 • 38 citations

Relative and Absolute Configuration of the Fumonisin B1 Backbone

1994 • 35 citations

Relative configuration of the C-10 to C-16 fragment of fumonisin B1

1995 • 31 citations

Relative and absolute stereochemistry of the fumonisin B2 backbone

1994 • 28 citations

Activation of a retinoblastoma-protein-dependent pathway by sphingosine

1995 • 22 citations

Relative stereochemistry of fumonisin B1 at C-2 and C-3

1994 • 21 citations

Bradykinin Increases Ceramide and Sphingosine Content in Human Fibroblasts: Possible Involvement of Glycosphingolipids

1996 • 19 citations

Sphingosine and sphingosine 1-phosphate in cellular proliferation: relationship with protein kinase C and phosphatidic acid.

1993 • 19 citations

Bioactive Properties of Sphingosine and Structurally Related Compounds

1996 • 14 citations

Studies on the Biosynthesis of Ceramide. Does the Reversed Ceramidase Reaction Yield Ceramides?

1980 • 13 citations

Relative configuration of the C-1 to C-5 fragment of fumonisin B1

1994 • 3 citations

Relative stereochemistry of fumonisin B1 at C-2 and C-3

1994 • 3 citations

Reactivity of Sphingosine Base in Enzymatic Synthesis of Ceramide

1972 • 3 citations

Deleted Work

1955 • 0 citations