Biliary cancer growth factor pathways, cyclo‐oxygenase‐2 and potential therapeutic strategies

Liver Regeneration

1997 • 2,731 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

The Effect of Celecoxib, a Cyclooxygenase-2 Inhibitor, in Familial Adenomatous Polyposis

2000 • 2,505 citations

Cyclooxygenase in biology and disease

1998 • 2,483 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

Antiangiogenic and antitumor activities of cyclooxygenase-2 inhibitors.

2000 • 1,310 citations

Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment.

1998 • 1,086 citations

Biliary Tract Cancers

1999 • 944 citations

Chemopreventive activity of celecoxib, a specific cyclooxygenase-2 inhibitor, against colon carcinogenesis.

1998 • 933 citations

Cyclooxygenase-2 Inhibitors in Tumorigenesis (Part I)

1998 • 773 citations

Cyclooxygenase-2 expression is up-regulated in human pancreatic cancer.

1999 • 692 citations

A neu acquaintance for ErbB3 and ErbB4: A role for receptor heterodimerization in growth signaling

1994 • 601 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

Sensitivity of HER-2/neu antibodies in archival tissue samples: potential source of error in immunohistochemical studies of oncogene expression.

1994 • 495 citations

Cyclooxygenase 2 expression in Barrett's esophagus and adenocarcinoma: Ex vivo induction by bile salts and acid exposure

2000 • 453 citations

Increased cyclooxygenase-2 levels in carcinogen-induced rat colonic tumors

1996 • 438 citations

Molecular pathology of cyclooxygenase-2 in neoplasia.

2000 • 406 citations

Elevated interleukin 6 is induced by prostaglandin E2 in a murine model of inflammation: possible role of cyclooxygenase-2.

1996 • 301 citations

Increased expression of cyclooxygenase-2 protein in human gastric carcinoma.

2000 • 248 citations

Risk factors for biliary tract carcinogenesis

1999 • 246 citations

Regulation of Cyclooxygenase-2 pathway by HER2 receptor

1999 • 226 citations

Cyclooxygenase-1 and -2 isoenzymes

1999 • 215 citations

CDX1 protein expression in normal, metaplastic, and neoplastic human alimentary tract epithelium

1997 • 214 citations

Hepatocyte growth factor/hepatopoietin A is expressed in fat-storing cells from rat liver but not myofibroblast-like cells derived from fat-storing cells

1992 • 212 citations

Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line

1999 • 208 citations

Inhibition of tumor growth and invasion by a four-kringle antagonist (HGF/NK4) for hepatocyte growth factor

1998 • 177 citations

Hepatocyte growth factor (HGF) receptor expression is inducible and is part of the delayed-early response to HGF.

1994 • 161 citations

Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro

1994 • 156 citations

Metaplasia and precursor lesions of gallbladder carcinoma. Frequency, distribution, and probability of detection in routine histologic samples

1993 • 142 citations

Human intrahepatic biliary epithelial cells proliferate in vitro in response to human hepatocyte growth factor.

1992 • 141 citations

Immunohistochemical demonstration of MET overexpression in human intrahepatic cholangiocarcinoma and in hepatolithiasis

1998 • 133 citations

Growth control of human biliary epithelial cells by interleukin 6, hepatocyte growth factor, transforming growth factor β1, and activin a: Comparison of a cholangiocarcinoma cell line with primary cultures of non-neoplastic biliary epithelial cells

2000 • 127 citations

Down-regulation of HER2/neu expression induces apoptosis in human cancer cells that overexpress HER2/neu.

2000 • 107 citations

The Role of COX‐2 in Intestinal Cancer

1999 • 99 citations

Chemoprevention of colorectal cancer through inhibition of cyclooxygenase-2.

1999 • 97 citations

Amplification of the c-erbB-2 (HER-2/neu) gene in gastric cancer cells. Detection by fluorescence in situ hybridization.

1997 • 96 citations

HGF triggers activation of the COX‐2 gene in rat gastric epithelial cells: action mediated through the ERK2 signaling pathway

1999 • 90 citations

Interleukin‐6 functions as an autocrine growth factor in a cholangiocarcinoma cell line

1994 • 90 citations

Phenotypic characterization of metaplastic intestinal glands and ductular hepatocytes in cholangiofibrotic lesions rapidly induced in the caudate liver lobe of rats treated with furan.

1991 • 87 citations

Overexpression of C-NEU and C-MET during rat liver cholangiocarcinogenesis: A link between biliary intestinal metaplasia and mucin-producing cholangiocarcinoma

1999 • 83 citations

Oncogene expression in cholangiocarcinoma and in normal hepatic development

1989 • 82 citations

c‐erbB‐2 protein is expressed in hepatolithiasis and cholangiocarcinoma

1998 • 73 citations

"Intestinal-type" of adenocarcinoma preferentially induced in right/caudate liver lobes of rats treated with furan.

1993 • 72 citations

Significance of intestinal metaplasia for the evolution of cancer in the biliary tract

1984 • 71 citations

Significance of c-erbB-2 expression in normal and neoplastic epithelium of biliary tract.

1995 • 70 citations

Retreatment of chronic hepatitis B e antigen-positive patients with recombinant interferon alfa-2a

1999 • 58 citations

Intestinal-Type Adenocarcinoma of the Gallbladder

1986 • 56 citations

Perceptions of Herceptin®: A Monoclonal Antibody for the Treatment of Breast Cancer

1999 • 55 citations

c-erbB-2 oncogene expression in hepatocellular carcinoma and cholangiocarcinoma

1992 • 53 citations

Identification of multiple mRNA and DNA sequences from small tissue samples isolated by laser-assisted microdissection.

1998 • 51 citations

Biliary Proliferation and Adaptation in Furan-Induced Rat Liver Injury and Carcinogenesis

1996 • 49 citations

Biliary and pancreatic ductal epithelia : pathobiology and pathophysiology

1997 • 47 citations

Unique epithelial cell production of hepatocyte growth factor/scatter factor by putative precancerous intestinal metaplasias and associated “intestinal-type” biliary cancer chemically induced in rat liver

2000 • 44 citations

Expression of an Intestine-Specific Transcription Factor (CDX1) in Intestinal Metaplasia and in Subsequently Developed Intestinal Type of Cholangiocarcinoma in Rat Liver

2000 • 41 citations

Histochemical and immunohistochemical studies on development of biliary carcinoma in forty-seven patients with choledochal cyst—Special reference to intestinal metaplasia in the biliary duct—

1985 • 41 citations

Genetic Aberrations Detected by Comparative Genomic Hybridization in Biliary Tract Cancers

1999 • 37 citations

Sequential appearance of intestinal mucosal cell types in the right and caudate liver lobes of furan-treated rats

1992 • 35 citations

Domain-specific Interactions between the p185 and Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

1999 • 33 citations

NEU overexpression in the furan rat model of cholangiocarcinogenesis compared with biliary ductal cell hyperplasia.

1997 • 32 citations

Immunoreactivity for c-erbB-2 oncopeptide in benign and malignant diseases of the liver.

1992 • 32 citations

‘Metaplastic lesions’ in intrahepatic bile ducts in hepatolithiasis: A histochemical and immunohistochemical study

1990 • 29 citations

Hepatocyte Growth Factor Up-Regulates MET Expression in Rat Fetal Hepatocytes in Primary Culture

1994 • 27 citations

Characterization and growth regulation of a rat intrahepatic bile duct epithelial cell line under hormonally defined, serum-free conditions

1998 • 24 citations

Establishment of a novel rat cholangiocarcinoma cell culture model

1999 • 21 citations

Microdissection and Molecular Genetic Analysis of HER2/neu in Breast Carcinoma

1995 • 21 citations

Establishment of a functional HGF/C-MET autocrine loop in spontaneous transformants of WB-F344 rat liver stem-like cells

1998 • 17 citations

[Evaluation of immunoreactivity to erbB-2 protein as a marker of prognosis in bile duct carcinoma].

1992 • 5 citations