Inhibition of interleukin 6-mediated mitogen-activated protein kinase activation attenuates growth of a cholangiocarcinoma cell line

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

PD 098059 Is a Specific Inhibitor of the Activation of Mitogen-activated Protein Kinase Kinase in Vitro and in Vivo

1995 • 3,456 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Induction of Apoptosis by ASK1, a Mammalian MAPKKK That Activates SAPK/JNK and p38 Signaling Pathways

1997 • 2,284 citations

SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin‐1

1995 • 2,080 citations

Interleukin-6: An Overview

1990 • 1,910 citations

<scp>gp</scp>130 AND THE INTERLEUKIN-6 FAMILY OF CYTOKINES

1997 • 1,468 citations

Cyclin D1 Expression Is Regulated Positively by the p42/p44 and Negatively by the p38/HOG Pathway

1996 • 1,203 citations

Interleukin 6 and its Receptor: Ten Years Later

1998 • 774 citations

Apoptosis Induced by Withdrawal of Trophic Factors Is Mediated by p38 Mitogen-activated Protein Kinase

1997 • 471 citations

Interleukin‐6: Structure‐function relationships

1997 • 358 citations

Increases of intracellular magnesium promote glycodeoxycholate-induced apoptosis in rat hepatocytes.

1994 • 270 citations

Alterations in pancreatic, biliary, and breast carcinomas support MKK4 as a genetically targeted tumor suppressor gene.

1998 • 185 citations

Regulation of intracellular pH by immortalized human intrahepatic biliary epithelial cell lines

1994 • 181 citations

Human biliary epithelial cells secrete and respond to cytokines and hepatocyte growth factors in vitro: Interleukin-6, hepatocyte growth factor and epidermal growth factor promote DNA synthesis in vitro

1994 • 156 citations

Marked Elevation of Serum Interleukin-6 in Patients With Cholangiocarcinoma

1998 • 145 citations

Bcl-2 is overexpressed and alters the threshold for apoptosis in a cholangiocarcinoma cell line

1997 • 126 citations

The pathobiology of biliary epithelia

1997 • 121 citations

Lipopolysaccharide induces cholangiocyte proliferation via an interleukin-6-mediated activation of p44/p42 mitogen-activated protein kinase

1999 • 119 citations

Mammalian MAP kinase modules: how to transduce specific signals.

1997 • 105 citations

Relationship between interleukin‐6 and proliferation and differentiation in cholangiocarcinoma

1998 • 90 citations

Interleukin‐6 functions as an autocrine growth factor in a cholangiocarcinoma cell line

1994 • 90 citations

Selective induction of apoptosis in Hep 3B cells by topoisomerase I inhibitors: evidence for a protease-dependent pathway that does not activate cysteine protease P32.

1996 • 73 citations

Interleukin-6: a regulator of plasma protein gene expression in hepatic and non-hepatic tissues.

1990 • 62 citations

Cholangiocarcinoma: a review.

1997 • 61 citations

Biliary interleukin-6 and tumor necrosis factor-alpha in patients undergoing endoscopic retrograde cholangiopancreatography.

1997 • 52 citations

Sequence, Expression and Function of an mRNA Encoding a Soluble Form of the Human Interleukin-6 Receptor (sIL-6R)

1995 • 20 citations

Concentrations of bile and serum endotoxin and serum cytokines after biliary drainage for acute cholangitis.

1997 • 15 citations