Amplification of the c-erbB-2 (HER-2/neu) gene in gastric cancer cells. Detection by fluorescence in situ hybridization.

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

THE TWO HISTOLOGICAL MAIN TYPES OF GASTRIC CARCINOMA: DIFFUSE AND SO‐CALLED INTESTINAL‐TYPE CARCINOMA

1965 • 5,842 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

erb B-2 Is a Potent Oncogene When Overexpressed in NIH/3T3 Cells

1987 • 1,015 citations

The biology of erbB-2/nue/HER-2 and its role in cancer

1994 • 975 citations

Overexpression of the EGF receptor-related proto-oncogene erbB-2 in human mammary tumor cell lines by different molecular mechanisms.

1987 • 619 citations

Correlation of c-erbB-2 gene amplification and protein expression in human breast carcinoma with nodal status and nuclear grading.

1988 • 570 citations

Detection and quantitation of HER-2/neu gene amplification in human breast cancer archival material using fluorescence in situ hybridization.

1996 • 564 citations

ERBB2 amplification in breast cancer analyzed by fluorescence in situ hybridization.

1992 • 542 citations

In situ hybridization as a tool to study numerical chromosome aberrations in solid bladder tumors

1988 • 462 citations

Genetic alterations of the c-erbB-2 oncogene occur frequently in tubular adenocarcinoma of the stomach and are often accompanied by amplification of the v-erbA homologue.

1988 • 251 citations

The importance of circular DNA in mammalian gene amplification.

1989 • 234 citations

Localization of the human erbB-2 gene on normal and rearranged chromosomes 17 to bands q12–21.32

1989 • 200 citations

Elimination of extrachromosomally amplified MYC genes from human tumor cells reduces their tumorigenicity.

1992 • 175 citations

Detection of N-myc gene amplification by fluorescence in situ hybridization. Diagnostic utility for neuroblastoma.

1993 • 162 citations

Amplification and overexpression of the EGF receptor and c-erbB-2 proto-oncogenes in human stomach cancer

1991 • 159 citations

Expression of C-erbB-2 oncoprotein in gastric carcinoma. Immunoreactivity for C-erbB-2 protein is an independent indicator of poor short-term prognosis in patients with gastric carcinoma

1991 • 153 citations

Sporadic amplification of the HER2/neu protooncogene in adenocarcinomas of various tissues.

1988 • 134 citations

Overexpression of c‐ erb B‐2 protein in gastric cancer. Its correlation with long‐term survival of patients

1993 • 132 citations

Overexpression of c-erbB-2 protein in gastric cancer. Its correlation with long-term survival of patients

1993 • 116 citations

Patterns of epidermal growth factor receptor amplification in malignant gliomas.

1996 • 108 citations

Distinction of low grade from high grade human ovarian carcinomas on the basis of losses of heterozygosity on chromosomes 3, 6, and 11 and HER-2/neu gene amplification.

1991 • 108 citations

Clinicopathological significance of c‐erbB‐2 protein expression in human gastric carcinoma

1992 • 101 citations

Epidermal‐growth‐factor‐receptor expression is associated with rapid tumor proliferation in bladder cancer

1994 • 95 citations

c‐erbB‐2 proto‐oncogene expression and its relationship to survival in gastric carcinoma: An immunohistochemical study on archival material

1991 • 79 citations

The arrangement of interphase chromosomes: Structural and functional aspects

1989 • 72 citations

Alterations of oncogenes in metastatic tumours of human gastric carcinomas

1990 • 65 citations

The role of inverted duplication in the generation of gene amplification in mammalian cells

1991 • 46 citations

Interphase molecular cytogenetic analysis of epithelial ovarian carcinomas.

1993 • 45 citations

An immunohistochemical study of c‐erbb‐2 protein in gastric carcinomas and lymph‐node metastases: Is the c‐erbB‐2 protein really a prognostic indicator?

1993 • 45 citations

Extrachromosomal amplification of the epidermal growth factor receptor gene in a human colon carcinoma cell line

1991 • 39 citations

Analysis of chromosome 17p13 (p53 locus) alterations in gastric carcinoma cells by dual-color fluorescence in situ hybridization.

1996 • 39 citations

Fluorescence in situ hybridization evaluation of chromosome deletion patterns in prostate cancer.

1996 • 34 citations

Amplification of the 11q13 region in human carcinoma cell lines: A mechanistic view

1993 • 33 citations

Fluorescence In Situ Hybridization (FISH) Detection of MYCN Oncogene Amplification in Neuroblastoma Using Paraffin-Embedded Tissues

1995 • 27 citations