Cyclooxygenase-1 and -2 isoenzymes

PPAR-γ agonists inhibit production of monocyte inflammatory cytokines

1998 • 2,909 citations

Up-regulation of cyclooxygenase 2 gene expression in human colorectal adenomas and adenocarcinomas

1994 • 2,553 citations

Alterations in cellular adhesion and apoptosis in epithelial cells overexpressing prostaglandin endoperoxide synthase 2

1995 • 2,308 citations

A prostaglandin J2 metabolite binds peroxisome proliferator-activated receptor γ and promotes adipocyte differentiation

1995 • 2,036 citations

TIS10, a phorbol ester tumor promoter-inducible mRNA from Swiss 3T3 cells, encodes a novel prostaglandin synthase/cyclooxygenase homologue

1991 • 1,814 citations

Structural basis for selective inhibition of cyclooxygenase-2 by anti-inflammatory agents

1996 • 1,773 citations

PPARγ Promotes Monocyte/Macrophage Differentiation and Uptake of Oxidized LDL

1998 • 1,771 citations

Expression of a mitogen-responsive gene encoding prostaglandin synthase is regulated by mRNA splicing.

1991 • 1,734 citations

Human cyclooxygenase-2 cDNA.

1992 • 1,493 citations

The X-ray crystal structure of the membrane protein prostaglandin H2 synthase-1

1994 • 1,263 citations

Expression of cyclooxygenase-1 and -2 in human colorectal cancer.

1995 • 1,135 citations

Prostaglandin Endoperoxide H Synthases-1 and -2

1996 • 721 citations

PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS: A Nuclear Receptor Signaling Pathway in Lipid Physiology

1996 • 715 citations

Molecular cloning of human prostaglandin endoperoxide synthase type II and demonstration of expression in response to cytokines.

1993 • 710 citations

Expression of Cyclooxygenase-1 and Cyclooxygenase-2 in Human Breast Cancer

1998 • 665 citations

Cyclooxygenase-1 and -2 expression in rheumatoid synovial tissues. Effects of interleukin-1 beta, phorbol ester, and corticosteroids.

1994 • 661 citations

Primary structure of prostaglandin G/H synthase from sheep vesicular gland determined from the complementary DNA sequence.

1988 • 604 citations

Induction of vascular endothelial growth factor expression in synovial fibroblasts by prostaglandin E and interleukin‐1: a potential mechanism for inflammatory angiogenesis

1995 • 565 citations

Structure of the human cyclo-oxygenase-2 gene

1994 • 488 citations

Induction of cyclooxygenase-2 by interleukin-1 alpha. Evidence for post-transcriptional regulation.

1994 • 478 citations

Isolation and characterization of the complementary DNA for sheep seminal vesicle prostaglandin endoperoxide synthase (cyclooxygenase).

1988 • 431 citations

Purification and characterisation of prostaglandin endoperoxide synthetase from sheep vesicular glands

1977 • 421 citations

Role of prostaglandin E1 and copper in angiogenesis.

1982 • 393 citations

Prostaglandin hydroperoxidase, an integral part of prostaglandin endoperoxide synthetase from bovine vesicular gland microsomes.

1979 • 375 citations

In vivo cyclooxygenase expression in synovial tissues of patients with rheumatoid arthritis and osteoarthritis and rats with adjuvant and streptococcal cell wall arthritis.

1992 • 353 citations

Down-regulation of cytokine-induced cyclo-oxygenase-2 transcript isoforms by dexamethasone: evidence for post-transcriptional regulation

1996 • 235 citations

Prostaglandin endoperoxide synthase gene structure: Identification of the transcriptional start site and 5′-flanking regulatory sequences

1992 • 210 citations

MOLECULAR MECHANISMS OF PROSTAGLANDIN TRANSPORT

1998 • 192 citations

Cyclooxygenase Gene Expression in Inflammation and Angiogenesis^a

1993 • 169 citations

Expression of lipocalin-type prostaglandin D synthase (β-trace) in human heart and its accumulation in the coronary circulation of angina patients

1997 • 160 citations

Somatic hypermutation: How many mechanisms diversify V region sequences?

1995 • 116 citations

Prostaglandin A Compounds as Antiviral Agents

1980 • 115 citations

Non-small cell lung cancer cycloxygenase activity and proliferation are inhibited by non-steroidal antiinflammatory drugs.

1998 • 106 citations

Tumorigenic Transformation of Immortalized ECV Endothelial Cells by Cyclooxygenase-1 Overexpression

1997 • 101 citations

Restoration of prostacyclin synthase in vascular smooth muscle cells after aspirin treatment: regulation by epidermal growth factor.

1985 • 98 citations

Co-oxidation of benzidine by prostaglandin synthase and comparison with the action of horseradish peroxidase.

1983 • 96 citations

Dissociation of Basal Turnover and Cytokine-Induced Transcript Stabilization of the Human Cyclooxygenase-2 mRNA by Mutagenesis of the 3′-Untranslated Region

1998 • 81 citations

Mechanism of enhanced fibroblast arachidonic acid metabolism by mononuclear cell factor.

1984 • 74 citations

Isolation of the cDNA for human prostaglandin H synthase

1986 • 55 citations

Biological actions of δ12-prostaglandin J2

1995 • 39 citations

Novel intracellular signaling function of prostaglandin H synthase-1 in NF-kappa B activation.

1995 • 33 citations

Chapter 14. Prostanoid receptors and signal transduction

1996 • 31 citations

Aspirin and other nonsteroid anti-inflammatory drugs as cancer-preventive agents.

1996 • 17 citations

Brussels inquiry criticizes BSE secrecy

1996 • 7 citations

Battle to boost the status of French universities

1998 • 6 citations

Britain awaits impact of 1993 reforms

1994 • 1 citations

Deleted Work

1955 • 0 citations