Domain-specific Interactions between the p185 and Epidermal Growth Factor Receptor Kinases Determine Differential Signaling Outcomes

Human Breast Cancer: Correlation of Relapse and Survival with Amplification of the HER-2/ neu Oncogene

1987 • 11,429 citations

Studies of the HER-2/ neu Proto-Oncogene in Human Breast and Ovarian Cancer

1989 • 6,734 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

ErbB-2, the preferred heterodimerization partner of all ErbB receptors, is a mediator of lateral signaling

1997 • 1,554 citations

Targeted Disruption of Mouse EGF receptor: Effect of Genetic Background on Mutant Phenotype

1995 • 1,457 citations

Requirement for neuregulin receptor erbB2 in neural and cardiac development

1995 • 1,272 citations

Similarity of protein encoded by the human c-erb-B-2 gene to epidermal growth factor receptor

1986 • 1,226 citations

The neu oncogene: an erb-B-related gene encoding a 185,000-Mr tumour antigen

1984 • 1,153 citations

Aberrant neural and cardiac development in mice lacking the ErbB4 neuregulin receptor

1995 • 1,108 citations

Epidermal growth factor regulates p21ras through the formation of a complex of receptor, Grb2 adapter protein, and Sos nucleotide exchange factor

1993 • 1,077 citations

A Hierarchical Network of Interreceptor Interactions Determines Signal Transduction by Neu Differentiation Factor/Neuregulin and Epidermal Growth Factor

1996 • 1,021 citations

Multiple independent activations of the neu oncogene by a point mutation altering the transmembrane domain of p185

1986 • 1,020 citations

Control of EGF Receptor Signaling by Clathrin-Mediated Endocytosis

1996 • 998 citations

Diversification of Neu differentiation factor and epidermal growth factor signaling by combinatorial receptor interactions.

1996 • 772 citations

Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors.

1989 • 742 citations

Ligand-specific activation of HER4/p180erbB4, a fourth member of the epidermal growth factor receptor family.

1993 • 724 citations

Insect cell-expressed p180erbB3 possesses an impaired tyrosine kinase activity.

1994 • 692 citations

Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells

1987 • 657 citations

Increased expression of the putative growth factor receptor p185HER2 causes transformation and tumorigenesis of NIH 3T3 cells.

1987 • 627 citations

Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas.

1995 • 546 citations

Oncoprotein Networks

1997 • 532 citations

A point mutation in the neu oncogene mimics ligand induction of receptor aggregation

1989 • 432 citations

The Cellular Response to Neuregulins Is Governed by Complex Interactions of the erbB Receptor Family

1995 • 364 citations

Intermolecular association of the p185 protein and EGF receptor modulates EGF receptor function

1990 • 362 citations

The erbB3 gene product is a receptor for heregulin.

1994 • 361 citations

Synergistic interaction of p185c-neu and the EGF receptor leads to transformation of rodent fibroblasts

1989 • 316 citations

Constitutive Activation of Phosphatidylinositol 3-Kinase by a Naturally Occurring Mutant Epidermal Growth Factor Receptor

1998 • 304 citations

Neu and its ligands: From an oncogene to neural factors

1993 • 286 citations

Variants of 3T3 cells lacking mitogenic response to epidermal growth factor.

1977 • 280 citations

Endocytosis of growth factor receptors

1993 • 277 citations

The phosphatidylinositol 3-kinase alpha is required for DNA synthesis induced by some, but not all, growth factors.

1994 • 270 citations

Heterodimerization of the erbB-1 and erbB-2 receptors in human breast carcinoma cells: a mechanism for receptor transregulation

1990 • 246 citations

Efficient coupling with phosphatidylinositol 3-kinase, but not phospholipase C gamma or GTPase-activating protein, distinguishes ErbB-3 signaling from that of other ErbB/EGFR family members.

1994 • 231 citations

EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions.

1988 • 226 citations

Egf binding to its receptor triggers a rapid tyrosine phosphorylation of the erbB-2 protein in the mammary tumor cell line SK-BR-3.

1988 • 226 citations

Transformation of NIH 3T3 Cells by HER3 or HER4 Receptors Requires the Presence of HER1 or HER2

1996 • 208 citations

Transformational and altered signal transduction by a naturally occurring mutant EGF receptor.

1996 • 195 citations

The neu-oncogene: signal transduction pathways, transformation mechanisms and evolving therapies.

1994 • 186 citations

Requirement for the Adapter Protein GRB2 in EGF Receptor Endocytosis

1996 • 178 citations

Monoclonal antibodies identify a cell-surface antigen associated with an activated cellular oncogene

1984 • 158 citations

Heterodimerization of epidermal growth factor receptorand wild-type or kinase-deficient Neu: a mechanism of interreceptor kinaseactivation and transphosphorylation.

1994 • 157 citations

Ligand and p185c-neu density govern receptorinteractions and tyrosine kinase activation.

1994 • 92 citations

Linkage of tyrosine kinase activity with transforming ability of the p185neu oncoprotein.

1989 • 89 citations

HER4-mediated Biological and Biochemical Properties in NIH 3T3 Cells

1996 • 80 citations

Tumor promoter and epidermal growth factor stimulate phosphorylation of the c-erbB-2 gene product in MKN-7 human adenocarcinoma cells.

1988 • 80 citations

p185c-neu and epidermal growth factor receptor associate into a structure composed of activated kinases.

1992 • 78 citations

Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products.

1988 • 76 citations

Kinase-deficient neu proteins suppress epidermal growth factor receptor function and abolish cell transformation.

1994 • 68 citations

Trans receptor inhibition of human glioblastoma cells by erbB family ectodomains

1997 • 54 citations

Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: implications for subdomain contributions to receptor assembly

1998 • 54 citations

Endosomes, receptor tyrosine kinase internalization and signal transduction

1995 • 46 citations

Intermolecular association and trans-phosphorylation of different neu-kinase forms permit SH2-dependent signaling and oncogenic transformation.

1995 • 33 citations

Effects of Platelet-derived Growth Factor on Phosphorylation of the Epidermal Growth Factor Receptor in Human Skin Fibroblasts

1989 • 30 citations

Expression, purification, and characterization of Bacneu. A soluble protein tyrosine kinase domain encoded by the neu-oncogene.

1992 • 13 citations

Carboxyl-terminal deletion and point mutations decrease the transforming potential of the activated rat neu oncogene product.

1992 • 11 citations

Association of Signaling Proteins with a Nonmitogenic Heterodimeric Complex Composed of Epidermal Growth Factor Receptor and Kinase-Inactive p185^c-neu"

1996 • 11 citations

A structural and kinetic comparison of proto-oncogenic and oncogenic neu holo-receptors expressed in insect cells.

1993 • 8 citations