Beyond receptors: Multiple second‐messenger systems in brain

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Studies and Perspectives of Protein Kinase C

1986 • 5,148 citations

Multiple receptors for dopamine

1979 • 3,739 citations

Inositol trisphosphate and diacylglycerol as second messengers

1984 • 3,535 citations

Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate

1983 • 2,596 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Turnover of Inositol Phospholipids and Signal Transduction

1984 • 1,629 citations

Molecular Biology of Learning: Modulation of Transmitter Release

1982 • 1,534 citations

Phorbol diester receptor copurifies with protein kinase C.

1983 • 1,185 citations

The effects of lithium ion and other agents on the activity of myo-inositol-1-phosphatase from bovine brain.

1980 • 1,099 citations

Multiple, Distinct Forms of Bovine and Human Protein Kinase C Suggest Diversity in Cellular Signaling Pathways

1986 • 1,044 citations

Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase

1985 • 960 citations

Calcium messenger system: an integrated view.

1984 • 916 citations

Protein kinase C as a possible receptor protein of tumor-promoting phorbol esters.

1983 • 890 citations

The Complete Primary Structure of Protein Kinase C—the Major Phorbol Ester Receptor

1986 • 878 citations

GTP-binding proteins couple cardiac muscarinic receptors to a K channel

1985 • 868 citations

Tolerance of locus coeruleus neurones to morphine and suppression of withdrawal response by clonidine

1978 • 794 citations

ENZYME SECRETION AND THE INCORPORATION OF P32 INTO PHOSPHOLIPIDES OF PANCREAS SLICES

1953 • 757 citations

Protein kinase C phosphorylates the inhibitory guanine‐nucleotide‐binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase

1985 • 736 citations

RECEPTORS AND PHOSPHOINOSITIDE-GENERATED SECOND MESSENGERS

1985 • 722 citations

The inositol tris/tetrakisphosphate pathway—demonstration of Ins(l,4,5)P3 3-kinase activity in animal tissues

1986 • 702 citations

Cloning and expression of multiple protein kinase C cDNAs

1986 • 683 citations

GTP-binding proteins mediate transmitter inhibition of voltage-dependent calcium channels

1986 • 666 citations

Potentiation of synaptic transmission in the hippocampus by phorbol esters

1986 • 647 citations

Rapid formation of inositol 1,3,4,5-tetrakisphosphate following muscarinic receptor stimulation of rat cerebral cortical slices

1985 • 641 citations

Purification and properties of the inhibitory guanine nucleotide regulatory unit of brain adenylate cyclase.

1984 • 585 citations

Noradrenaline blocks accommodation of pyramidal cell discharge in the hippocampus

1982 • 583 citations

The second messenger linking receptor activation to internal Ca release in liver

1984 • 557 citations

The inositol trisphosphate phosphomonoesterase of the human erythrocyte membrane

1982 • 541 citations

Translocation of Protein Kinase C Activity May Mediate Hippocampal Long-Term Potentiation

1986 • 532 citations

Uncoupling of cardiac muscarinic and β-adrenergic receptors from ion channels by a guanine nucleotide analogue

1985 • 527 citations

The regulatory component of adenylate cyclase. Purification and properties.

1981 • 505 citations

Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase.

1984 • 498 citations

Purification of the regulatory component of adenylate cyclase.

1980 • 497 citations

The Glucagon-sensitive Adenyl Cyclase System in Plasma Membranes of Rat Liver

1971 • 487 citations

Enhancement of calcium current in Aplysia neurones by phorbol ester and protein kinase C

1985 • 476 citations

The odorant-sensitive adenylate cyclase of olfactory receptor cells. Differential stimulation by distinct classes of odorants.

1986 • 433 citations

Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle.

1985 • 417 citations

Activation of protein kinase C potentiates isoprenaline-induced cyclic AMP accumulation in rat pinealocytes

1985 • 415 citations

Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery

1984 • 389 citations

Mechanism of adenylate cyclase activation through the beta-adrenergic receptor: catecholamine-induced displacement of bound GDP by GTP.

1978 • 372 citations

A role of calcium-activated phospholipid-dependent protein kinase in human platelet activation. Comparison of thrombin and collagen actions.

1983 • 368 citations

Protein kinase C regulates ionic conductance in hippocampal pyramidal neurons: electrophysiological effects of phorbol esters.

1985 • 361 citations

Protein kinase C phosphorylates human platelet inositol trisphosphate 5′-phosphomonoesterase, increasing the phosphatase activity

1986 • 354 citations

The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition.

1984 • 345 citations

Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain.

1986 • 341 citations

Inositol 1,4,5-trisphosphate: a possible chemical link in excitation-contraction coupling in muscle.

1985 • 330 citations

Receptor-Coupled Activation of Phosphoinositide-Specific Phospholipase C by an N Protein

1986 • 324 citations

Stepwise enzymatic dephosphorylation of inositol 1,4,5-trisphosphate to inositol in liver

1984 • 321 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

Depletion of norepinephrine, but not serotonin, reduces long-term potentiation in the dentate gyrus of rat hippocampal slices

1985 • 314 citations

Kinase C activator 1,2-oleoylacetylglycerol attenuates voltage-dependent calcium current in sensory neurons.

1986 • 313 citations

Cyclic adenosine 3',5'‐monophosphate mediates beta‐receptor actions of noradrenaline in rat hippocampal pyramidal cells.

1986 • 308 citations

A saturable receptor for 32P-inositol-l,4,5-trisphosphate in hepatocytes and neutrophils

1986 • 296 citations

Characterization of a specific phorbol ester aporeceptor in mouse brain cytosol.

1983 • 292 citations

The Molecular Basis of Communication within the Cell

1985 • 282 citations

Formation and metabolism of inositol 1,3,4,5-tetrakisphosphate in liver.

1986 • 280 citations

Message Transmission: Receptor Controlled Adenylate Cyclase System

1984 • 275 citations

Drug and Neurotransmitter Receptors in the Brain

1984 • 274 citations

Heterogeneous localization of protein kinase C in rat brain: autoradiographic analysis of phorbol ester receptor binding

1986 • 267 citations

The role of cyclic nucleotides in central synaptic function

1975 • 263 citations

Increased brain myo-inositol 1-phosphate in lithium-treated rats

1976 • 252 citations

Inositol trisphosphate receptor localization in brain: variable stoichiometry with protein kinase C

1987 • 249 citations

Inositol 1,4,5-trisphosphate mimics muscarinic response in Xenopus oocytes

1985 • 249 citations

Ns and Ni, the stimulatory and inhibitory regulatory components of adenylyl cyclases. Purification of the human erythrocyte proteins without the use of activating regulatory ligands.

1984 • 242 citations

Pertussis toxin blocks the outward currents evoked by opiate and α2-agonists in locus coeruleus neurons

1986 • 241 citations

Enhancement of adenylate cyclase activity in S49 lymphoma cells by phorbol esters. Putative effect of C kinase on alpha s-GTP-catalytic subunit interaction.

1985 • 239 citations

Amino acid sequence of retinal transducin at the site ADP-ribosylated by cholera toxin.

1984 • 235 citations

Isolation of a phosphomonoesterase from human platelets that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate.

1985 • 233 citations

Mechanisms for inhibition of the catalytic activity of adenylate cyclase by the guanine nucleotide-binding proteins serving as the substrate of islet-activating protein, pertussis toxin.

1986 • 233 citations

Inositol trisphosphate enhances calcium release in skinned cardiac and skeletal muscle

1986 • 232 citations

Modulation of adenylate cyclase of human platelets by phorbol ester

1985 • 225 citations

Similarity of junctions between plasma membranes and endoplasmic reticulum in muscle and neurons.

1976 • 222 citations

1,2-Diacylglycerol and phorbol ester inhibit agonist-induced formation of inositol phosphates in human platelets: possible implications for negative feedback regulation of inositol phospholipid hydrolysis.

1985 • 222 citations

Phorbol esters mimic some cholinergic actions in hippocampal pyramidal neurons

1986 • 219 citations

Mechanism of action of the phorbol ester tumor promoters: Specific receptors for lipophilic ligands

1984 • 209 citations

The pharmacology of cholinergic excitatory responses in hippocampal pyramidal cells

1984 • 206 citations

Physical and immunological characterization of a guanine nucleotide-binding protein purified from bovine cerebral cortex.

1985 • 205 citations

5-Hydroxytryptamine-stimulated inositol phospholipid hydrolysis in rat cerebral cortex slices: pharmacological characterization and effects of antidepressants.

1985 • 198 citations

Serotonin-stimulated phosphoinositide turnover: mediation by the S2 binding site in rat cerebral cortex but not in subcortical regions.

1985 • 197 citations

Binding of protein kinase C to neutrophil membranes in the presence of Ca2+ and its activation by a Ca2+-requiring proteinase.

1985 • 193 citations

Muscarinic agonist binding and phospholipid turnover in brain.

1983 • 185 citations

Autophosphorylation of rat brain Ca2+-activated and phospholipid-dependent protein kinase.

1986 • 183 citations

Bradykinin-activated transmembrane signals are coupled via No or Ni to production of inositol 1,4,5-trisphosphate, a second messenger in NG108-15 neuroblastoma-glioma hybrid cells.

1986 • 182 citations

Mapping second messenger systems in the brain: differential localizations of adenylate cyclase and protein kinase C.

1986 • 181 citations

Phorbol esters inhibit agonist-induced [3H] inositol-1-phosphate accumulation in rat hippocampal slices

1984 • 180 citations

Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase.

1986 • 177 citations

Ca2+ regulates the inositol tris/tetrakisphosphate pathway in intact and broken preparations of insulin-secreting RINm5F cells.

1986 • 177 citations

The Role of Cyclic Nucleotides in Central Synaptic Function

1975 • 177 citations

Widespread occurrence of "87 kDa," a major specific substrate for protein kinase C.

1986 • 176 citations

Go, a guanine nucleotide-binding protein: immunohistochemical localization in rat brain resembles distribution of second messenger systems.

1986 • 169 citations

Relationships within the family of GTP-binding proteins isolated from bovine central nervous system.

1985 • 160 citations

Actions of inositol phosphates on Ca2+ pools in guinea-pig hepatocytes

1984 • 158 citations

Regional Differences in the Coupling of Muscarinic Receptors to Inositol Phospholipid Hydrolysis in Guinea Pig Brain

1985 • 151 citations

Phorbol ester effects on neurotransmission: interaction with neurotransmitters and calcium in smooth muscle.

1985 • 149 citations

Temperature and nucleotide dependence of calcium release by myo-inositol 1,4,5-trisphosphate in cultured vascular smooth muscle cells.

1985 • 148 citations

Prevention of the agonist binding to gamma-aminobutyric acid B receptors by guanine nucleotides and islet-activating protein, pertussis toxin, in bovine cerebral cortex. Possible coupling of the toxin-sensitive GTP-binding proteins to receptors.

1985 • 148 citations

Binding sites for inositol trisphosphate in the bovine adrenal cortex

1985 • 145 citations

Binding of inositol trisphosphate by a liver microsomal fraction

1986 • 145 citations

Primary structure of the α‐subunit of bovine adenylate cyclase‐stimulating G‐protein deduced from the cDNA sequence

1986 • 142 citations

Calcium in the spine apparatus of dendritic spines in the dentate molecular layer

1983 • 138 citations

Bidirectional control of cytosolic free calcium by thyrotropin-releasing hormone in pituitary cells

1985 • 135 citations

Clinical Implications of Guanine Nucleotide–Binding Proteins as Receptor–Effector Couplers

1985 • 132 citations

Opiate- and alpha 2-adrenoceptor-induced hyperpolarizations of locus ceruleus neurons in brain slices: reversal by cyclic adenosine 3':5'- monophosphate analogues

1985 • 132 citations

Cyclic AMP and cyclic GMP accumulation in vitro in brain regions of young, old and aged rats

1978 • 125 citations

Opiate Receptor‐Mediated Inhibition of Adenylate Cyclase in Rat Striatal Plasma Membranes

1982 • 121 citations

Properties of adenylate cyclase from senescent rat brain

1973 • 112 citations

Phorbol 12,13-dibutyrate and 1-oleyl-2-acetyldiacylglycerol stimulate inositol trisphosphate dephosphorylation in human platelets.

1986 • 110 citations

Neural and molecular mechanisms underlying information storage in Aplysia: implications for learning and memory

1985 • 107 citations

Inositol cyclic phosphates are produced by cleavage of phosphatidylphosphoinositols (polyphosphoinositides) with purified sheep seminal vesicle phospholipase C enzymes.

1985 • 103 citations

Interactions of Divalent Cations and Guanine Nucleotides at α₂‐Noradrenergic Receptor Binding Sites in Bovine Brain Mechanisms

1980 • 99 citations

Vasopressin rapidly stimulates phosphatidic acid‐phosphatidylinositol turnover in rat anterior pituitary cells

1985 • 97 citations

An Examination of the Involvement of Phospholipases A₂ and C in the α‐Adrenergic and γ‐Aminobutyric Acid Receptor Modulation of Cyclic AMP Accumulation in Rat Brain Slices

1986 • 97 citations

Inositol bis-, tris-, and tetrakis(phosphate)s: analysis in tissues by HPLC.

1986 • 93 citations

Histamine H₁‐Receptor Binding Sites in Guinea Pig Brain Membranes: Regulation of Agonist Interactions by Guanine Nucleotides and Cations

1980 • 91 citations

Impairment of brain neurotransmitter receptors in aged rats

1980 • 87 citations

Protein kinase C mediated regulation of calcium channels in PC-12 pheochromocytoma cells

1986 • 84 citations

Accumulation of inositol phosphates and cyclic AMP in guinea-pig cerebral cortical preparations

1985 • 83 citations

Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process.

1986 • 78 citations

Cyclic Nucleotides in the Nervous System

1984 • 76 citations

Acetylcholine release from guinea pig caudate slices evoked by phorbol ester and calcium

1986 • 75 citations

Occurrence of a hormone-sensitive inhibitory coupling component of the adenylate cyclase in S49 lymphoma cyc- variants.

1983 • 72 citations

Olfactory dysfunction in humans with deficient guanine nucleotide-binding protein

1986 • 69 citations

Inhibitory regulation of adenylyl cyclase in the absence of stimulatory regulation. Requirements and kinetics of guanine nucleotide-induced inhibition of the cyc- S49 adenylyl cyclase.

1983 • 65 citations

Adenosine A1 Receptors Are Associated with Cerebellar Granule Cells

1983 • 63 citations

Characterization of D-myo-inositol 1,4,5-trisphosphate phosphatase in rat brain

1986 • 61 citations

myo-Inositol 1,4,5-trisphosphate mobilizes Ca2+ from isolated adipocyte endoplasmic reticulum but not from plasma membranes

1986 • 54 citations

Role of inositol 1,4,5‐trisphosphate in excitation‐contraction coupling in skeletal muscle

1986 • 53 citations

High-affinity binding of forskolin to rat brain membranes.

1985 • 45 citations

Co-localized adenosine A1 and gamma-aminobutyric acid B (GABAB) receptors of cerebellum may share a common adenylate cyclase catalytic unit.

1985 • 44 citations

Blockade of D-2 dopamine receptors strongly enhances the potency of enkephalins to inhibit dopamine-sensitive adenylate cyclase in rat neostriatum: involvement of delta- and mu-opioid receptors

1986 • 44 citations

Pertussis toxin blocks somatostatin inhibition of calcium mobilization and reduces the affinity of somatostatin receptors for agonists.

1985 • 41 citations

Treatment of the “on‐off” phenomenon in parkisnonism with lithium carbonate

1982 • 29 citations

Lithium dampens neurotransmitter response in smooth muscle: relevance to action in affective illness.

1986 • 26 citations

Noradrenaline-stimulated inositol phospholipid breakdown in rat dorsal lateral geniculate nucleus neurones

1986 • 18 citations