Molecular Biology of Learning: Modulation of Transmitter Release

Habituation: A model phenomenon for the study of neuronal substrates of behavior.

1966 • 2,489 citations

Quantal components of the end‐plate potential

1954 • 2,182 citations

Perception and the Conditioned Reflex

1966 • 2,147 citations

An Adenosine 3′,5′-Monophosphate-dependant Protein Kinase from Rabbit Skeletal Muscle

1968 • 1,423 citations

Muscarinic suppression of a novel voltage-sensitive K+ current in a vertebrate neurone

1980 • 1,423 citations

Higher Nervous Functions: The Orienting Reflex

1963 • 1,009 citations

Purification and Characterization of a Protein Inhibitor of Adenosine 3',5'-Monophosphate-dependent Protein Kinases

1971 • 892 citations

CYCLIC NUCLEOTIDE-DEPENDENT PROTEIN KINASES, IV. WIDESPREAD OCCURRENCE OF ADENOSINE 3′,5′-MONOPHOSPHATE-DEPENDENT PROTEIN KINASE IN VARIOUS TISSUES AND PHYLA OF THE ANIMAL KINGDOM

1969 • 775 citations

The distribution and dissociation of cyclic adenosine 3':5'-monophosphate-dependent protein kinases in adipose, cardiac, and other tissues.

1975 • 758 citations

Possible role for cyclic nucleotides and phosphorylated membrane proteins in postsynaptic actions of neurotransmitters†

1976 • 694 citations

dunce, a mutant of Drosophila deficient in learning.

1976 • 620 citations

Tetrodotoxin‐resistant electric activity in presynaptic terminals

1969 • 613 citations

Statistical factors involved in neuromuscular facilitation and depression

1954 • 582 citations

The timing of calcium action during neuromuscular transmission

1967 • 564 citations

Neurotransmitters decrease the calcium conductance activated by depolarization of embryonic chick sensory neurones.

1981 • 555 citations

Neuronal Correlates of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 529 citations

Synaptic Facilitation and Behavioral Sensitization in Aplysia : Possible Role of Serotonin and Cyclic AMP

1976 • 515 citations

Memory in Mice as Affected by Intracerebral Puromycin

1963 • 507 citations

Neuronal Mechanisms of Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 477 citations

Studies on the properties and mode of action of the purified regulatory subunit of bovine heart adenosine 3‘:5‘-monophosphate-dependent protein kinase.

1978 • 467 citations

Defect in cyclic AMP phosphodiesterase due to the dunce mutation of learning in Drosophila melanogaster

1981 • 444 citations

Habituation and Dishabituation of the Gill-Withdrawal Reflex in Aplysia

1970 • 427 citations

Properties of Two Inward Membrane Currents in the Heart

1979 • 409 citations

Presynaptic modulation of voltage-dependent Ca ²⁺ current: Mechanism for behavioral sensitization in Aplysia californica

1978 • 385 citations

Intracellular injection of t he catalytic subunit of cyclic AMP-dependent protein kinase simulates facilitation of transmitter release underlying behavioral sensitization in Aplysia.

1980 • 380 citations

The effect of magnesium on the activity of motor nerve endings

1954 • 378 citations

Presynaptic Facilitation as a Mechanism for Behavioral Sensitization in Aplysia

1976 • 369 citations

Mechanism of calcium current modulation underlying presynaptic facilitation and behavioral sensitization in Aplysia.

1980 • 363 citations

The Pharmacology of Memory: A Neurobiological Perspective

1981 • 331 citations

Cyclic adenosine 5'-monophosphate in Escherichia coli

1976 • 324 citations

A Quantal Analysis of the Synaptic Depression Underlying Habituation of the Gill-Withdrawal Reflex in Aplysia

1974 • 313 citations

Microinjection of catalytic subunit of cyclic AMP-dependent protein kinase enhances calcium action potentials of bag cell neurons in cell culture

1980 • 306 citations

Cyclic AMP and contractile activity in heart.

1977 • 291 citations

Classical conditioning in a simple withdrawal reflex in Aplysia californica

1981 • 279 citations

The role of cyclic nucleotides in central synaptic function

1975 • 263 citations

An analysis of associative learning in a terrestrial mollusc

1981 • 261 citations

Modulatory Actions of Neurotransmitters

1979 • 252 citations

Primary Changes of Membrane Currents During Retention of Associative Learning

1982 • 229 citations

Three Drosophila mutations that block associative learning also affect habituation and sensitization.

1982 • 224 citations

Facilitatory transmitter causes a selective and prolonged increase in adenosine 3':5'-monophosphate in sensory neurons mediating the gill and siphon withdrawal reflex in Aplysia

1982 • 215 citations

An Analysis of Dishabituation and Sensitization of The Gill-Withdrawal Reflex In Aplysia

1971 • 213 citations

Mechanism of heterosynaptic facilitation in the giant cell of the abdominal ganglion of Aplysia depilans.

1965 • 202 citations

Crayfish escape behavior and central synapses. II. Physiological mechanisms underlying behavioral habituation.

1972 • 202 citations

Crayfish escape behavior and central synapses. I. Neural circuit exciting lateral giant fiber.

1972 • 200 citations

Synaptic Plasticity and the Modulation of the Ca2+ Current

1980 • 190 citations

Retention of an Associative Behavioral Change in Hermissenda

1978 • 190 citations

Characterization and comparison of membrane-associated and cytosolic cAMP-dependent protein kinases. Physicochemical and immunological studies on bovine cerebral cortex protein kinases.

1979 • 188 citations

Identification, characterization, and quantitative measurement of cyclic AMP receptor proteins in cytosol of various tissues using a photoaffinity ligand.

1977 • 188 citations

Receptive fields and response properties of mechanoreceptor neurons innervating siphon skin and mantle shelf in Aplysia.

1974 • 183 citations

Electrical Inexcitability of Synapses and Some Consequences in the Central Nervous System

1957 • 181 citations

Cellular Analysis of Long-Term Habituation of the Gill-Withdrawal Reflex of Aplysia californica

1978 • 177 citations

Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica

1972 • 173 citations

Functioning of identified neurons and synapses in abdominal ganglion of Aplysia in absence of protein synthesis.

1971 • 172 citations

Associative Learning in Aplysia : Evidence for Conditioned Fear in an Invertebrate

1981 • 165 citations

A family of genes that codes for ELH, a neuropeptide eliciting a stereotyped pattern of behavior in Aplysia

1982 • 163 citations

Local, reflex, and central commands controlling gill and siphon movements in Aplysia.

1974 • 158 citations

Associative Learning in Aplysia : Cellular Correlates Supporting a Conditioned Fear Hypothesis

1981 • 157 citations

Neurochemistry of Learning and Memory: An Evaluation of Recent Data

1980 • 146 citations

Prolonged Inhibition in Burst Firing Neurons: Synaptic Inactivation of the Slow Regenerative Inward Current

1978 • 127 citations

Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. I. Identification and characterization.

1981 • 125 citations

Response decrement of the flexion reflex in the acute spinal cat and transient restoration by strong stimuli.

1966 • 125 citations

Mechanisms of slow postsynaptic potentials

1981 • 124 citations

Learning: Classical and Avoidance Conditioning in the Mollusk Pleurobranchaea

1973 • 113 citations

Classical conditioning in Aplysia californica.

1979 • 112 citations

Contribution of individual mechanoreceptor sensory neurons to defensive gill-withdrawal reflex in Aplysia

1978 • 107 citations

Role of cyclic AMP in a serotonin-evoked slow inward current in snail neurones

1981 • 101 citations

A Common Presynaptic Locus for the Synaptic Changes Underlying Short-term Habituation and Sensitization of the Gill-withdrawal Reflex in Aplysia

1976 • 99 citations

Presynaptic membrane potential affects transmitter release in an identified neuron in Aplysia by modulating the Ca ²⁺ and K ⁺ currents

1980 • 98 citations

Cyclic Adenosine Monophosphate in the Nervous System of Aplysia californica

1972 • 97 citations

Learning: Rapid Aversive Conditioning in the Gastropod MolluskPleurobranchaea

1975 • 92 citations

Aplysia californica : Analysis of Nuclear DNA in Individual Nuclei of Giant Neurons

1971 • 86 citations

Inactivation without facilitation of calcium conductance in caesium-loaded neurones of Aplysia

1978 • 80 citations

Serotonin induces a voltage-sensitive calcium current in neurons of Aplysia californica.

1980 • 77 citations

Activation and nuclear translocation of protein kinase during transsynaptic induction of tyrosine 3-monooxygenase.

1976 • 73 citations

DNA sequence organization in the mollusc aplysia californica

1975 • 66 citations

The expression of long lasting afterdischarge by isolated Aplysia bag cell neurons

1981 • 65 citations

Cellular studies of peripheral neurons in siphon skin of Aplysia californica

1979 • 62 citations

Sensitization in Aplysia : Restoration of Transmission in Synapses Inactivated by Long-Term Habituation

1979 • 59 citations

Role of serotonin and cyclic AMP on facilitation of the fast conducting system activity in the leechHirudo Medicinalis

1982 • 57 citations

Effects of nystatin on membrane conductance and internal ion activities inAplysia neurons

1977 • 54 citations

Genesis and maturation of serotonergic vesicles in identified giant cerebral neuron of Aplysia

1980 • 48 citations

Preparation of Tritium-labelled Talc

1973 • 46 citations

Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. IV. Morphological basis of presynaptic facilitation.

1981 • 45 citations

Interneurons involved in mediation and modulation of gill-withdrawal reflex in Aplysia. III. Identified facilitating neurons increase Ca2+ current in sensory neurons.

1981 • 43 citations

Sensitization and association in eyelid conditioning.

1943 • 32 citations

A prolonged, voltage‐dependent calcium permeability revealed by tetraethylammonium in the soma and axon of Aplysia giant neuron

1977 • 31 citations

The immunofluorescent localization of regulatory and catalytic subunits of cyclic AMP-dependent protein kinase in neuronal and glial cell types of the central nervous system

1981 • 30 citations

Characterization and localization of adenosine 3':5'-monophosphate- binding proteins in the nervous system of Aplysia

1982 • 29 citations

Direct control of action potentials by acetylcholine in bullfrog sympathetic ganglion cells

1975 • 27 citations

Neuronal Models for Conditioned Reflexes

1966 • 26 citations

Species Specificity of Brain Cyclic AMP Receptor Proteins

1981 • 17 citations

Genes and learning in Drosophila

1980 • 13 citations

Biophysical Analysis of the Function of Receptors

1980 • 12 citations