TNF Receptor p55 Plays a Pivotal Role in Murine Keratinocyte Apoptosis Induced by Ultraviolet B Irradiation

Identification of programmed cell death in situ via specific labeling of nuclear DNA fragmentation.

1992 • 9,540 citations

An Essential Role for NF-κB in Preventing TNF-α-Induced Cell Death

1996 • 3,094 citations

Programmed Cell Death in Animal Development

1997 • 2,690 citations

Suppression of TNF-α-Induced Apoptosis by NF-κB

1996 • 2,623 citations

Tumor suppressor p53 is a regulator of bcl-2 and bax gene expression in vitro and in vivo.

1994 • 2,141 citations

Tumor Necrosis Factor (TNF)

1985 • 1,932 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

The Pathophysiology of Tumor Necrosis Factors

1992 • 1,880 citations

Autoantigens targeted in systemic lupus erythematosus are clustered in two populations of surface structures on apoptotic keratinocytes.

1994 • 1,722 citations

Mice deficient for the 55 kd tumor necrosis factor receptor are resistant to endotoxic shock, yet succumb to L. monocytogenes infection

1993 • 1,719 citations

Sunburn and p53 in the onset of skin cancer

1994 • 1,501 citations

The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor

1995 • 1,311 citations

A novel domain within the 55 kd TNF receptor signals cell death

1993 • 1,302 citations

Induction of apoptosis in mature T cells by tumour necrosis factor

1995 • 1,139 citations

Programmed cell death: Apoptosis and oncogenesis

1991 • 856 citations

The two different receptors for tumor necrosis factor mediate distinct cellular responses.

1991 • 815 citations

Early Lethality, Functional NF-κB Activation, and Increased Sensitivity to TNF-Induced Cell Death in TRAF2-Deficient Mice

1997 • 791 citations

Human keratinocytes are a source for tumor necrosis factor alpha: evidence for synthesis and release upon stimulation with endotoxin or ultraviolet light.

1990 • 707 citations

Differentiation between cellular apoptosis and necrosis by the combined use of in situ tailing and nick translation techniques.

1994 • 697 citations

NF-kappa B activation by ultraviolet light not dependent on a nuclear signal

1993 • 646 citations

Decreased sensitivity to tumour-necrosis factor but normal T-cell development in TNF receptor-2-deficient mice

1994 • 607 citations

Cloning and expression of cDNAs for two distinct murine tumor necrosis factor receptors demonstrate one receptor is species specific.

1991 • 576 citations

Ultraviolet Light Induces Apoptosis via Direct Activation of CD95 (Fas/APO-1) Independently of Its Ligand CD95L

1998 • 472 citations

Epidermal Langerhans cells from normal human skin bind monomeric IgE via Fc epsilon RI.

1992 • 388 citations

Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.

1994 • 344 citations

The p70 tumor necrosis factor receptor mediates cytotoxicity

1992 • 277 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 275 citations

Ultraviolet-B-Induced Apoptosis of Keratinocytes: Evidence for Partial Involvement of Tumor Necrosis Factor-α in the Formation of Sunburn Cells

1995 • 272 citations

Production of IL-18 (IFN-gamma-inducing factor) messenger RNA and functional protein by murine keratinocytes.

1997 • 267 citations

Apoptosis in human skin development: Morphogenesis, periderm, and stem cells

1994 • 259 citations

Divergent induction of apoptosis and IL-8 secretion in HT-29 cells in response to TNF-alpha and ligation of Fas antigen.

1995 • 248 citations

Tumor necrosis factor-induced apoptosis during the poisoning of mice with hepatotoxins

1997 • 203 citations

Wavelength specific patterns of p53 induction in human skin following exposure to UV radiation.

1993 • 195 citations

Photocarcinogenesis, skin cancer, and aging

1983 • 187 citations

Ia Antigens in Mouse Skin Are Predominantly Expressed on Langerhans Cells

1979 • 185 citations

Fas/Fas Ligand Interaction Contributes to UV-Induced Apoptosis in Human Keratinocytes

1997 • 183 citations

Enhancement of TNF receptor p60-mediated cytotoxicity by TNF receptor p80: requirement of the TNF receptor-associated factor-2 binding site.

1997 • 183 citations

Molecular cloning and expression of the type 1 and type 2 murine receptors for tumor necrosis factor.

1991 • 160 citations

Epidermal Growth Factors and Cytokines

1993 • 125 citations

ILA, a member of the human nerve growth factor/tumor necrosis factor receptor family, regulates T-lymphocyte proliferation and survival

1996 • 109 citations

Induction of apoptotic cell death in non‐melanoma skin cancer by interferon‐α

1995 • 107 citations

Inhibition of p75 Tumor Necrosis Factor Receptor by Antisense Oligonucleotides Increases Hypoxic Injury and β-Amyloid Toxicity in Human Neuronal Cell Line

1997 • 99 citations

Effects of growth factors on the antiproliferative activity of tumor necrosis factors.

1987 • 96 citations

TNF receptor-2-triggered apoptosis is associated with the down-regulation of Bcl-xL on activated T cells and can be prevented by CD28 costimulation.

1997 • 79 citations

Reversal of immunosuppression inducible through ultraviolet-exposed skin by in vivo anti-CD11b treatment.

1996 • 77 citations

Modulation of Apo‐1/Fas (CD95)‐induced programmed cell death in myeloma cells by interferon‐α₂

1996 • 68 citations

Aging and the Skin

1989 • 66 citations

Effect of gene-targeted mutation in TNF receptor (p55) on contact hypersensitivity and ultraviolet B-induced immunosuppression.

1995 • 55 citations

The type B receptor for tumor necrosis factor-alpha mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells

1992 • 49 citations

Enhanced growth of murine melanoma in ultraviolet-irradiated skin is associated with local inhibition of immune effector mechanisms.

1996 • 46 citations

Contribution of the CD28 molecule to allergic and irritant-induced skin reactions in CD28 -/- mice.

1996 • 39 citations

Ultraviolet light suppresses IFN-gamma-induced IL-7 gene expression in murine keratinocytes by interfering with IFN regulatory factors.

1997 • 36 citations

Molecular Cloning and Expression of the Type 1 and Type 2 Murine Receptors for Tumor Necrosis Factor

1991 • 36 citations

Local and systemic consequences of acute, low‐dose ultraviolet B radiation are mediated by different immune regulatory mechanisms

1994 • 34 citations

Interleukin-6 prevents dexamethasone-induced myeloma cell death

1994 • 32 citations

Overview: Mechanisms of apoptosis

1993 • 22 citations

Interleukin-2 Reverses the Defect in Activation-Induced Apoptosis in T Cells from AutoimmunelprMice

1998 • 21 citations

Potent carcinogenicity of uncovered halogen lamps in hairless mice.

1994 • 21 citations

Tumor necrosis factor receptor genes,TNFR1 andTNFR2, on human chromosomes 12 and 1

1991 • 16 citations

Cytokines

1997 • 4 citations

The type B receptor for tumor necrosis factor-alpha mediates DNA fragmentation in HL-60 and U937 cells and differentiation in HL-60 cells

1992 • 3 citations