Biology of common β receptor–signaling cytokines IL-3, IL-5, and GM-CSF

TH1 and TH2 Cells: Different Patterns of Lymphokine Secretion Lead to Different Functional Properties

1989 • 7,558 citations

The phosphatidylinositol 3-Kinase–AKT pathway in human cancer

2002 • 5,914 citations

The Phosphoinositide 3-Kinase Pathway

2002 • 5,427 citations

Predominant T_H2-like Bronchoalveolar T-Lymphocyte Population in Atopic Asthma

1992 • 2,802 citations

Interleukin-3-Induced Phosphorylation of BAD Through the Protein Kinase Akt

1997 • 2,245 citations

A family of cytokine-inducible inhibitors of signalling

1997 • 2,055 citations

Effects of an interleukin-5 blocking monoclonal antibody on eosinophils, airway hyper-responsìveness, and the late asthmatic response

2000 • 1,834 citations

ENDOCYTOSIS AND MOLECULAR SORTING

1996 • 1,537 citations

A new protein containing an SH2 domain that inhibits JAK kinases

1997 • 1,413 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Structure and function of a new STAT-induced STAT inhibitor

1997 • 1,308 citations

CYTOKINES: COORDINATORS OF IMMUNE AND INFLAMMATORY RESPONSES

1990 • 1,304 citations

Signaling through the JAK/STAT pathway, recent advances and future challenges

2002 • 1,132 citations

Granulocyte/macrophage colony-stimulating factor-deficient mice show no major perturbation of hematopoiesis but develop a characteristic pulmonary pathology.

1994 • 866 citations

Eosinophil's Role Remains Uncertain as Anti–Interleukin-5 only Partially Depletes Numbers in Asthmatic Airway

2003 • 807 citations

A novel cytokine-inducible gene CIS encodes an SH2-containing protein that binds to tyrosine-phosphorylated interleukin 3 and erythropoietin receptors.

1995 • 761 citations

Inhibition of Stat1-mediated gene activation by PIAS1

1998 • 760 citations

Eosinophils, T-lymphocytes, mast cells, neutrophils, and macrophages in bronchial biopsy specimens from atopic subjects with asthma: Comparison with biopsy specimens from atopic subjects without asthma and normal control subjects and relationship to bronchial hyperresponsiveness

1991 • 681 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Haemopoietic receptors and helical cytokines

1990 • 642 citations

Expression cloning of the human IL-3 receptor cDNA reveals a shared β subunit for the human IL-3 and GM-CSF receptors

1991 • 617 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Role for interleukin-3 in mast-cell and basophil development and in immunity to parasites

1998 • 568 citations

Interleukin-5 Expression in the Lung Epithelium of Transgenic Mice Leads to Pulmonary Changes Pathognomonic of Asthma

1997 • 527 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Activated T cells and eosinophilia in bronchoalveolar lavages from subjects with asthma correlated with disease severity

1991 • 472 citations

Th1 And Th2 Cells: Different Patterns Of Lymphokine Secretion Lead To Different Functional Properties

1989 • 460 citations

Clinical Immunology: Principles and Practice

2012 • 396 citations

Regulation of Bad Phosphorylation and Association with Bcl-xL by the MAPK/Erk Kinase

1999 • 385 citations

Inhibition of Allergic Inflammation in a Murine Model of Asthma by Expression of a Dominant-Negative Mutant of GATA-3

1999 • 333 citations

IL-5 enhances the in vitro adhesion of human eosinophils, but not neutrophils, in a leucocyte integrin (CD11/18)-dependent manner.

1990 • 328 citations

Suppression of apoptotic death in hematopoietic cells by signalling through the IL-3/GM-CSF receptors.

1995 • 321 citations

Emerging Applications of Recombinant Human Granulocyte-Macrophage Colony-Stimulating Factor

1998 • 316 citations

Mice deficient for the IL-3/GM-CSF/IL-5 βc receptor exhibit lung pathology and impaired immune response, while βIL3 receptor-deficient mice are normal

1995 • 313 citations

Hematopoietic and lung abnormalities in mice with a null mutation of the common beta subunit of the receptors for granulocyte-macrophage colony-stimulating factor and interleukins 3 and 5.

1995 • 311 citations

Elevated expression of IL-3Rα in acute myelogenous leukemia is associated with enhanced blast proliferation, increased cellularity, and poor prognosis

2002 • 302 citations

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils

1991 • 299 citations

Negative regulation of the JAK/STAT pathway

1999 • 288 citations

Regulation of BAD phosphorylation at serine 112 by the Ras-mitogen-activated protein kinase pathway

1999 • 258 citations

Interleukin-3 receptor alpha chain (CD123) is widely expressed in hematologic malignancies.

2001 • 258 citations

A novel dimer configuration revealed by the crystal structure at 2.4 Å resolution of human interleukin-5

1993 • 247 citations

Allergen-induced increases in IL-5 receptor alpha-subunit expression on bone marrow-derived CD34+ cells from asthmatic subjects. A novel marker of progenitor cell commitment towards eosinophilic differentiation.

1997 • 242 citations

Requirement of Lyn and Syk tyrosine kinases for the prevention of apoptosis by cytokines in human eosinophils.

1996 • 238 citations

The mechanism of IL-5 signal transduction

1998 • 236 citations

Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5

1989 • 229 citations

Defective B-1 Cell Development and Impaired Immunity against Angiostrongylus cantonensis in IL-5Rα-Deficient Mice

1996 • 223 citations

Regulation of Proliferation, Differentiation and Survival by the IL-3/IL-5/GM-CSF Receptor Family

1998 • 218 citations

Nonhematopoietic tumor cells express functional GM-CSF receptors

1989 • 212 citations

Mechanism of Activation of the GM‐CSF, IL‐3, and IL‐5 Family of Receptors

1998 • 194 citations

IL-5 receptor-mediated tyrosine phosphorylation of SH2/SH3-containing proteins and activation of Bruton's tyrosine and Janus 2 kinases.

1994 • 178 citations

Structural comparisons among the short-chain helical cytokines

1994 • 161 citations

Regulation of Bcl-2 expression by oncogenic Ras protein in hematopoietic cells.

1995 • 151 citations

HLA-DR and -DQ epitopes and monoclonal antibody specificity

1989 • 150 citations

Molecular basis of the membrane-anchored and two soluble isoforms of the human interleukin 5 receptor alpha subunit.

1992 • 140 citations

In vivoactivation of JAK2/STAT‐3 pathway during angiogenesis induced by GM‐CSF

2001 • 140 citations

Autoantibodies against Granulocyte Macrophage Colony–Stimulating Factor Are Diagnostic for Pulmonary Alveolar Proteinosis

2002 • 135 citations

JAK2 Is Essential for Activation of c-fos and c-myc Promoters and Cell Proliferation through the Human Granulocyte-Macrophage Colony-stimulating Factor Receptor in BA/F3 Cells

1996 • 133 citations

Role of IL-5 in Innate and Adaptive Immunity to LarvalStrongyloides stercoralisin Mice

2000 • 123 citations

Raf/MAPK and rapamycin-sensitive pathways mediate the anti-apoptotic function of p21Ras in IL-3-dependent hematopoietic cells

1997 • 118 citations

Cytokine-Specific Transcriptional Regulation Through an IL-5Rα Interacting Protein

2001 • 117 citations

A Novel Role for IL-3: Human Monocytes Cultured in the Presence of IL-3 and IL-4 Differentiate into Dendritic Cells That Produce Less IL-12 and Shift Th Cell Responses Toward a Th2 Cytokine Pattern

2002 • 114 citations

Residue 21 of human granulocyte-macrophage colony-stimulating factor is critical for biological activity and for high but not low affinity binding.

1992 • 112 citations

Induction of immune system mediators in the hippocampal formation in Alzheimer's and Parkinson's diseases: Selective effects on specific interleukins and interleukin receptors

1994 • 111 citations

Guidebook to cytokines and their receptors

1995 • 106 citations

Structure of the Complete Extracellular Domain of the Common β Subunit of the Human GM-CSF, IL-3, and IL-5 Receptors Reveals a Novel Dimer Configuration

2001 • 101 citations

Specificity in cytokine signal transduction: lessons learned from the IL-3/IL-5/GM-CSF receptor family

2001 • 98 citations

Anti-GM-CSF Titer Predicts Response to GM-CSF Therapy in Pulmonary Alveolar Proteinosis

2002 • 98 citations

Enforced Granulocyte/Macrophage Colony-stimulating Factor Signals Do Not Support Lymphopoiesis, but Instruct Lymphoid to Myelomonocytic Lineage Conversion

2003 • 96 citations

Granulocyte-macrophage Colony-stimulating Factor Provokes RAS Activation and Transcription of c-fos through Different Modes of Signaling

1996 • 95 citations

Src Homology 2 Protein Tyrosine Phosphatase (SHPTP2)/Src Homology 2 Phosphatase 2 (SHP2) Tyrosine Phosphatase Is a Positive Regulator of the Interleukin 5 Receptor Signal Transduction Pathways Leading to the Prolongation of Eosinophil Survival

1997 • 93 citations

Activation of p38 MAP Kinase Pathway by Erythropoietin and Interleukin-3

1997 • 89 citations

Cytokines: Coordinators Of Immune And Inflammatory Responses

1990 • 81 citations

Two contiguous residues in human interleukin-3, Asp21 and Glu22, selectively interact with the alpha- and beta-chains of its receptor and participate in function.

1994 • 81 citations

Site-Specific Serine Phosphorylation of the IL-3 Receptor Is Required for Hemopoietic Cell Survival

2000 • 78 citations

Activation of src-related tyrosine kinases by IL-3.

1995 • 77 citations

Uterine eosinophils and reproductive performance in interleukin 5-deficient mice

2000 • 74 citations

A role for JNK/SAPK in proliferation, but not apoptosis, of IL-3-dependent cells

1997 • 73 citations

SHP1 and SHP2 Protein-tyrosine Phosphatases Associate with βc after Interleukin-3-induced Receptor Tyrosine Phosphorylation

1997 • 69 citations

Growth factors and cytokines in health and disease

1997 • 69 citations

Cultured human intestinal mast cells express functional IL-3 receptors and respond to IL-3 by enhancing growth and IgE receptor-dependent mediator release

2002 • 66 citations

Interleukin-5 Enhances the in vitro Adhesion of Human Eosinophils, but Not Neutrophils, in a Leucocyte Integrin (CD11/18)-Dependent Manner

1991 • 63 citations

Interleukin‐5 deficient mice exhibit impaired host defence against challenge Trichinella spiralis infections

2000 • 59 citations

Identification and characterization of a low-affinity granulocyte- macrophage colony-stimulating factor receptor on primary and cultured human melanoma cells

1991 • 59 citations

The beta subunit of human granulocyte-macrophage colony-stimulating factor receptor forms a homodimer and is activated via association with the alpha subunit.

1996 • 59 citations

Identification of Key Charged Residues of Human Interleukin-5 in Receptor Binding and Cellular Activation

1995 • 57 citations

Creation of a biologically active interleukin-5 monomer

1996 • 57 citations

Identification of a Cys Motif in the Common β Chain of the Interleukin 3, Granulocyte-Macrophage Colony-stimulating Factor, and Interleukin 5 Receptors Essential for Disulfide-linked Receptor Heterodimerization and Activation of All Three Receptors

1998 • 57 citations

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

1996 • 56 citations

IL-3, IL-5, granulocyte-macrophage colony- stimulating factor receptor α-subunit, and common β-subunit expression by peripheral leukocytes and blood dendritic cells☆☆☆★★★

1998 • 56 citations

Lymphokine induction of rat microglia multinucleated giant cell formation

1993 • 56 citations

Therapeutic efficacy of an anti–IL-5 monoclonal antibody delivered into the respiratory tract in a murine model of asthma☆☆☆★

1999 • 54 citations

Absolute Values of Dendritic Cell Subsets in Bone Marrow, Cord Blood, and Peripheral Blood Enumerated by a Novel Method

2003 • 54 citations

A cytokine receptor gene cluster in the X-Y pseudoautosomal region?

1993 • 51 citations

Identification of a 14-3-3 Binding Sequence in the Common β Chain of the Granulocyte-Macrophage Colony-Stimulating Factor (GM-CSF), Interleukin-3 (IL-3), and IL-5 Receptors That Is Serine-Phosphorylated by GM-CSF

1999 • 49 citations

Enhanced Expression of GM-CSF in Differentiating Eosinophils of Atopic and Atopic Asthmatic Subjects

1998 • 47 citations

Activation of 12-O-Tetradecanoylphorbol-13-acetate Response Element- and Dyad Symmetry Element-dependent Transcription by Interleukin-5 Is Mediated by Jun N-terminal Kinase/Stress-activated Protein Kinase Kinases

1997 • 47 citations

Interleukin‐3, but not granulocyte–macrophage colony‐stimulating factor and interleukin‐5, inhibits apoptosis of human basophils through phosphatidylinositol 3‐kinase: requirement of NF‐κB‐dependent and ‐independent pathways

2002 • 45 citations

Cloning of rat interleukin-3 receptor beta-subunit from cultured microglia and its mRNA expression in vivo

1995 • 42 citations

GM-CSF downmodulates c-kit, FcεRIα and GM-CSF receptor expression as well as histamine and tryptase levels in cultured human mast cells

2001 • 40 citations

Analysis of the survival of mature human eosinophils: interleukin-5 prevents apoptosis in mature human eosinophils

1991 • 40 citations

Negative regulation of receptor tyrosine kinase signals

2001 • 38 citations

Proteasomal regulation of βc signaling reveals a novel mechanism for cytokine receptor heterotypic desensitization

2001 • 38 citations

Interleukin-5 Transgene Expression and Eosinophilia Are Associated with Retarded Mammary Gland Development in Mice1

2003 • 35 citations

Suppression of apoptotic death in hematopoietic cells by signaling through the IL-3/GM-CSF receptors

1995 • 31 citations

Transient hematologic and clinical effect of E21R in a child with end-stage juvenile myelomonocytic leukemia

2002 • 30 citations

Eosinophilia associated with adult t-cell leukemia: Role of interleukin 5 and granulocyte-macrophage colony-stimulating factor

1998 • 29 citations

Expression of Cytokine Receptors on Follicular Dendritic Cells

1997 • 28 citations

Identification of primary structural features that define the differential actions of IL-3 and GM-CSF receptors

2002 • 27 citations

Multiple tyrosine residues in the intracellular domain of the common β subunit of the interleukin 5 receptor are involved in activation of STAT5

1997 • 26 citations

Uterine eosinophils and reproductive performance in interleukin 5-deficient mice

2000 • 26 citations

Nonhematopoietic tumor cells express functional GM-CSF receptors

1989 • 23 citations

The beta common chain (βc) of the granulocyte macrophage-colony stimulating factor, interleukin-3 and interleukin-5 receptors

1999 • 22 citations

Delineation of IL-5 domains predicted to engage the IL-5 receptor complex.

1996 • 18 citations

Activation of c-Jun N-terminal Kinase by Human Granulocyte Macrophage-Colony Stimulating Factor in BA/F3 Cells

1997 • 17 citations

Expression, crystallization and derivatization of the complete extracellular domain of the β_c subunit of the human IL‐5, IL‐3 and GM‐CSF receptors

2001 • 16 citations

Molecular Mechanisms of Dendritic Cell Sublineage Development from Human Hematopoietic Progenitor/Stem Cells

2003 • 16 citations

The functional basis of granulocyte-macrophage colony stimulating factor, interleukin-3 and interleukin-5 receptor activation, basic and clinical implications

1999 • 16 citations

Cloning and sequencing of the cDNAs encoding two alternative splicing-derived variants of the alpha subunit of the granulocyte-macrophage colony-stimulating factor receptor

1994 • 16 citations

Activation of p38 MAP Kinase Pathway by Erythropoietin and Interleukin-3

1997 • 14 citations

Structural and Functional Hot Spots in Cytokine Receptors

2001 • 12 citations

Cytokine Receptor Genes: Structure, Chromosomal Location, and Involvement in Human Disease

1995 • 11 citations

Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma

1996 • 11 citations

Molecular organization of the cytokine gene cluster, involving the human IL-3, IL-4, IL-5, and GM-CSF genes, on human chromosome 5

1989 • 9 citations

Identification and characterization of a low-affinity granulocyte- macrophage colony-stimulating factor receptor on primary and cultured human melanoma cells

1991 • 9 citations

Effect of granulocyte macrophage colony-stimulating factor in a patient with benign systemic mastocytosis.

2001 • 6 citations

Site-Specific Serine Phosphorylation of the IL-3 Receptor Is Required for Hemopoietic Cell Survival

2000 • 5 citations

Expression of Cytokine Receptors on Follicular Dendritic Cells

1997 • 4 citations

Changes of β‐amyloid precursor protein splice patterns in brain cell aggregate cultures

1994 • 2 citations

Engineering of a functional interleukin-5 monomer: a paradigm for redesigning helical bundle cytokines with therapeutic potential in allergy and asthma

1996 • 1 citations