Expression, crystallization and derivatization of the complete extracellular domain of the β_c subunit of the human IL‐5, IL‐3 and GM‐CSF receptors

[20] Processing of X-ray diffraction data collected in oscillation mode

1997 • 33,348 citations

The CCP4 suite: programs for protein crystallography

1994 • 17,203 citations

Solvent content of protein crystals

1968 • 7,954 citations

Human Growth Hormone and Extracellular Domain of Its Receptor: Crystal Structure of the Complex

1992 • 2,236 citations

Structural design and molecular evolution of a cytokine receptor superfamily.

1990 • 2,104 citations

Interleukin 5 deficiency abolishes eosinophilia, airways hyperreactivity, and lung damage in a mouse asthma model.

1996 • 1,382 citations

Molecular cloning of a second subunit of the receptor for human granulocyte-macrophage colony-stimulating factor (GM-CSF): reconstitution of a high-affinity GM-CSF receptor.

1990 • 650 citations

Crystal structure of the RNA-binding domain of the U1 small nuclear ribonucleoprotein A

1990 • 622 citations

A human high affinity interleukin-5 receptor (IL5R) is composed of an IL5-specific α chain and a β chain shared with the receptor for GM-CSF

1991 • 598 citations

IL-5-Deficient Mice Have a Developmental Defect in CD5+ B-1 Cells and Lack Eosinophilia but Have Normal Antibody and Cytotoxic T Cell Responses

1996 • 595 citations

Functional Mimicry of a Protein Hormone by a Peptide Agonist: The EPO Receptor Complex at 2.8 Å

1996 • 589 citations

Efficiency of signalling through cytokine receptors depends critically on receptor orientation

1998 • 543 citations

The X-ray structure of a growth hormone–prolactin receptor complex

1994 • 390 citations

Three-dimensional structure of CheY, the response regulator of bacterial chemotaxis

1989 • 350 citations

Relationship between interleukin-5 and eotaxin in regulating blood and tissue eosinophilia in mice.

1997 • 343 citations

Development of a Bicistronic Vector Driven by the Human Polypeptide Chain Elongation Factor 1α Promoter for Creation of Stable Mammalian Cell Lines That Express Very High Levels of Recombinant Proteins

1998 • 255 citations

Crystal Structure of the Interleukin-4/Receptor α Chain Complex Reveals a Mosaic Binding Interface

1999 • 216 citations

Modifications of Vectors pEF-BOS, pcDNA1 and pcDNA3 Result in Improved Convenience and Expression

1996 • 159 citations

Crystal structure of a cytokine-binding region of gp130

1998 • 125 citations

Reconstitution of the functional receptors for murine and human interleukin 5.

1993 • 111 citations

Multimeric cytokine receptors: common versus specific functions

1994 • 82 citations

Four-helix bundle growth factors and their receptors: protein-protein interactions

1995 • 73 citations

Recombinant human granulocyte and granulocyte–macrophage colony-stimulating factor (G-CSF and GM-CSF) administered following cytotoxic chemotherapy have a similar ability to mobilize peripheral blood stem cells

1998 • 52 citations

Structure of the activation domain of the GM-CSF/IL-3/IL-5 receptor common β-chain bound to an antagonist

2000 • 52 citations

Preparation of heavy-atom derivatives using site-directed mutagenesis

1989 • 43 citations

Use of site-directed mutagenesis to obtain isomorphous heavy-atom derivatives for protein crystallography: cysteine-containing mutants of phage T4 lysozyme

1987 • 36 citations

The influence of purification and protein heterogeneity on the crystallization of p‐hydroxybenzoate hydroxylase

1989 • 33 citations

Engineering cysteine mutants to obtain crystallographic phases with a cutinase from Fusarium solani pisi

1993 • 30 citations

Crystallographic phases through genetic engineering: experiences with colicin A

1989 • 16 citations

Engineering a heavy atom derivative for the X-ray structure analysis of cyclodextrin glycosyltransferase

1990 • 6 citations