Cu/Zn superoxide dismutase mRNA and enzyme activity, and susceptibility to lipid peroxidation, increases with aging in murine brains

Single-Step Method of RNA Isolation by Acid Guanidinium Thiocyanate–Phenol–Chloroform Extraction

1987 • 64,270 citations

Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction

1987 • 45,673 citations

A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity

1983 • 26,063 citations

The Role of Superoxide Anion in the Autoxidation of Epinephrine and a Simple Assay for Superoxide Dismutase

1972 • 8,501 citations

Hydroperoxide metabolism in mammalian organs.

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1981 • 1,871 citations

Toxic DNA Damage by Hydrogen Peroxide Through the Fenton Reaction in Vivo and in Vitro

1988 • 1,505 citations

Occurrence of neuropathological changes and dementia of Alzheimer's disease in Down's syndrome

1985 • 1,125 citations

The structure of the mouse glutathione peroxidase gene: the selenocysteine in the active site is encoded by the ‘termination’ codon, TGA.

1986 • 666 citations

The pattern of acquisition of plaques and tangles in the brains of patients under 50 years of age with Down's syndrome

1989 • 463 citations

Superoxide dismutase: correlation with life-span and specific metabolic rate in primate species.

1980 • 385 citations

Null mutation of copper/zinc superoxide dismutase in Drosophila confers hypersensitivity to paraquat and reduced longevity.

1989 • 381 citations

Spectrophotometric study of spontaneous disproportionation of superoxide anion radical and sensitive direct assay for superoxide dismutase.

1976 • 365 citations

Overproduction of human Cu/Zn-superoxide dismutase in transfected cells: extenuation of paraquat-mediated cytotoxicity and enhancement of lipid peroxidation.

1986 • 322 citations

Aspects of Free Radical Reactions in Biological Systems: Aging

1980 • 306 citations

Oxygen free radicals and Parkinson's disease

1991 • 293 citations

Drug Metabolism and Drug Toxicity

1985 • 249 citations

Changes in superoxide radical and lipid peroxide formation in the brain, heart and liver during the lifetime of the rat

1987 • 241 citations

Oxygen toxicity protecting enzymes in Parkinson's disease

1988 • 239 citations

Superoxide dismutase, glutathione peroxidase and lipoperoxidation in Oown's syndrome fetal brain

1984 • 224 citations

Superoxide dismutase, glutathione peroxidase, catalase, and lipid peroxidation in the major organs of the aging rats

1989 • 204 citations

Superoxide dismutase activity in Alzheimer's disease: possible mechanism for paired helical filament formation

1989 • 193 citations

Lipid Peroxidation and Glutathione Peroxidase, Glutathione Reductase, Superoxide Dismutase, Catalase, and Glucose‐6‐Phosphate Dehydrogenase Activities in FeCl₃‐Induced Epileptogenic Foci in the Rat Brain

1990 • 178 citations

Relationship between antioxidant defenses and longevity in different mammalian species

1990 • 175 citations

Regional Distributions of Thiobarbituric Acid‐Reactive Products, Activities of Enzymes Regulating the Metabolism of Oxygen Free Radicals, and Some of the Related Enzymes in Adult and Aged Rat Brains

1986 • 163 citations

Senile Dementias: Early Detection

1986 • 140 citations

Peroxide-producing potential of tissues: inverse correlation with longevity of mammalian species.

1985 • 131 citations

Superoxide Dismutase in the Rat and Mouse as a Function of Age and Longevity

1976 • 125 citations

Antioxidant Enzymes and Related Trace Elements in Aging Brain Capillaries and Choroid Plexus

1989 • 118 citations

Impaired neurotransmitter uptake in PC12 cells overexpressing human Cu/Zn-superoxide dimutase-implication for gene dosage effects in down syndrome

1988 • 118 citations

The use of standards for malonyldialdehyde

1975 • 113 citations

Alteration of endogenous glutathione peroxidase, manganese superoxide dismutase, and glutathione transferase activity in cells transfected with a copper-zinc superoxide dismutase expression vector. Explanation for variations in paraquat resistance.

1990 • 112 citations

Accumulation of dolichols in brains of elderly.

1982 • 106 citations

Differential Changes in Superoxide Dismutase Activity in Brain and Liver of Old Rats and Mice

1983 • 105 citations

Expression of transfected human CuZn superoxide dismutase gene in mouse L cells and NS20Y neuroblastoma cells induces enhancement of glutathione peroxidase activity

1988 • 96 citations

Brain membrane fluidity and lipid peroxidation in Alzheimer's disease

1990 • 95 citations

Age‐Dependent Variations in Peroxide‐Utilizing Enzymes from Rat Brain Mitochondria and Cytoplasm

1984 • 65 citations

Lipid Peroxidation and Superoxide Dismutase-1 and Glutathione Peroxidase Activities in Trisomy 16 Fetal Mice and Human Trisomy 21 Fibroblasts

1987 • 64 citations

Lipoperoxidation in human and rat brain tissue: Developmental and regional studies

1977 • 60 citations

Review of Genetic Investigations into the Aging Processes of Drosophila

1989 • 58 citations

Cloning and sequencing of a rat CuZn superoxide dismutase cDNA. Correlation between CuZn superoxide dismutase mRNA level and enzyme activity in rat and mouse tissues

1987 • 55 citations

Lipid abnormalities in the brain in adult Down’s syndrome and Alzheimer’s disease

1989 • 54 citations

Subcellular localization of superoxide dismutases, glutatione peroxidase and catalase in developing rat cerebral cortex

1989 • 52 citations

Premature aging changes in neuromuscular junctions of transgenic mice with an extra human CuZnSOD gene: A model for tongue pathology in Down's syndrome

1988 • 52 citations

Down syndrome clinical symptoms are manifested in transfected cells and transgenic mice overexpressing the human Cu/Zn-superoxide dismutase gene.

1990 • 48 citations

Changes induced by aging and drug treatment on cerebral enzymatic antioxidant system

1988 • 46 citations

Experimental burn-induced changes in lipid peroxide levels, and activity of superoxide dismutase and glutathione peroxidase in skin lesions, serum, and liver of mice

1988 • 37 citations

Isolation of a cDNA clone for murine catalase and analysis of an acatalasemic mutant.

1987 • 33 citations

Differential changes in Cu, Zn and Mn superoxide dismutase activity in developing rat brain and liver

1990 • 30 citations

Superoxide dismutase and life span ofDrosophila melanogaster

1979 • 26 citations

<b>SENSITIVE IMMUNOASSAY OF RAT Cu/Zn SUPEROXIDE DISMUTASE: CONCENTRATIONS IN THE BRAIN, LIVER, AND KIDNEY ARE NOT AFFECTED BY </b><b>AGING </b>

1990 • 25 citations

ROYAL WESTERN HOSPITAL.

1829 • 17 citations

Genetic coregulation of longevity and antioxienzymes in Neurospora crassa

1990 • 14 citations