High concentrations of antioxidants may not improve defense against oxidative stress

Principles of biochemistry

1978 • 5,242 citations

Oxygen-radical absorbance capacity assay for antioxidants

1993 • 1,560 citations

The antioxidants of human extracellular fluids

1990 • 1,352 citations

Principles of biochemistry

1983 • 809 citations

Is vitamin E the only lipid-soluble, chain-breaking antioxidant in human blood plasma and erythrocyte membranes?

1983 • 800 citations

Interaction of bovine erythrocyte superoxide dismutase with hydrogen peroxide. Inactivation of the enzyme

1975 • 777 citations

Role of vitamin E in preventing the oxidation of low-density lipoprotein

1991 • 649 citations

Inverse correlation between plasma vitamin E and mortality from ischemic heart disease in cross-cultural epidemiology.

1989 • 630 citations

A role for endothelial cell lipoxygenase in the oxidative modification of low density lipoprotein.

1989 • 417 citations

Ascorbic acid oxidation product(s) protect human low density lipoprotein against atherogenic modification. Anti- rather than prooxidant activity of vitamin C in the presence of transition metal ions.

1993 • 278 citations

Effect of Antioxidants on Oxidative Modification of LDL

1991 • 263 citations

Antioxidants in the prevention of human atherosclerosis. Summary of the proceedings of a National Heart, Lung, and Blood Institute Workshop: September 5-6, 1991, Bethesda, Maryland.

1992 • 247 citations

Copper salt-dependent hydroxyl radical formation

1983 • 242 citations

Damage to the DNA bases in mammalian chromatin by hydrogen peroxide in the presence of ferric and cupric ions

1991 • 240 citations

Site-specific Oxidative DNA Damage at Polyguanosines Produced by Copper Plus Hydrogen Peroxide

1989 • 239 citations

Plasma Antioxidant Vitamins and Subsequent Cancer Mortality in the 12-Year Follow-up of the Prospective Basel Study

1991 • 225 citations

Superoxide-dependent and ascorbate-dependent formation of hydroxyl radicals in the presence of copper salts: A physiologically significant reaction?

1983 • 205 citations

Mutation spectrum of copper-induced DNA damage.

1991 • 190 citations

Effect of hydrogen peroxide on calcium homeostasis in smooth muscle cells

1992 • 164 citations

Copper(II)‐catalyzed lipid peroxidation in liposomes and erythrocyte membranes

1982 • 138 citations

Hydroxyl radical production by H2O2 plus Cu,Zn-superoxide dismutase reflects the activity of free copper released from the oxidatively damaged enzyme.

1992 • 134 citations

Direct evidence for inhibition of free radical formation from Cu(I) and hydrogen peroxide by glutathione and other potential ligands using the EPR spin-trapping technique

1992 • 134 citations

Trolox protects rat hepatocytes against oxyradical damage and the ischemic rat liver from reperfusion injury

1991 • 107 citations

β-Carotene and cancer prevention: the Basel Study

1991 • 102 citations

Fluorescence‐based assay for reactive oxygen species: a protective role for creatinine

1988 • 96 citations

Uric acid substantially enhances the free radical‐induced inactivation of alcohol dehydrogenase

1984 • 78 citations

Single-strand cleavage of DNA by Cu(II) and thiols: A powerful chemical DNA-cleaving system

1989 • 55 citations

A Water-Soluble Quaternary Ammonium Analog of α-Tocopherol, that Scavenges Lipoperoxyl, Superoxyl and Hydroxyl Radicals

1991 • 36 citations

Determinants of serum α-tocopherol in Finnish adults

1988 • 23 citations

Haemolytic Activity of Copper as Influenced by Chelating Agents, Albumine and Chromium

1984 • 19 citations

Oxidative modification of low density lipoprotein

1990 • 7 citations

Effects of glucose, Trolox-C, and glutathione disulphide on lipid peroxidation and cell death induced by oxidant stress in rat heart

1992 • 7 citations