Potentiation of cellular antioxidant capacity by Bcl-2: implications for its antiapoptotic function

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Function and Activation of NF-kappaB in the Immune System

1994 • 4,698 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

NF-κB: Ten Years After

1996 • 3,008 citations

Cellular response to oxidative stress: Signaling for suicide and survival*

2002 • 2,258 citations

Antioxidant and redox regulation of gene transcription

1996 • 1,999 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Oxidative stress and nuclear factor-κB activation

2000 • 865 citations

Regulation of hepatic glutathione synthesis: current concepts and controversies

1999 • 858 citations

Activation of the IκBα Kinase Complex by MEKK1, a Kinase of the JNK Pathway

1997 • 712 citations

p38 and Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase Pathways Are Required for Nuclear Factor-κB p65 Transactivation Mediated by Tumor Necrosis Factor

1998 • 678 citations

bcl-2 inhibits death of central neural cells induced by multiple agents.

1993 • 631 citations

Regulation and measurement of oxidative stress in apoptosis

2002 • 567 citations

Multiple signals converging on NF-κB

1999 • 483 citations

Regulation of redox glutathione levels and gene transcription in lung inflammation: therapeutic approaches

2000 • 478 citations

Oxidative damage in neurodegenerative disease

1994 • 428 citations

Biologic sequelae of nuclear factor–κB blockade in multiple myeloma: therapeutic applications

2002 • 382 citations

Redox-dependent shift of OxyR-DNA contacts along an extended DNA-binding site: A mechanism for differential promoter selection

1994 • 379 citations

Protective effect of resveratrol on β-amyloid-induced oxidative PC12 cell death

2003 • 374 citations

NFκB and AP-1 mediate transcriptional responses to oxidative stress in skeletal muscle cells

2001 • 313 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

The role of NF-κB in the regulation of cell stress responses

2002 • 310 citations

Signalling apoptosis: a radical approach

2001 • 303 citations

Bcl-2 expression causes redistribution of glutathione to the nucleus

1998 • 297 citations

NF-κB to the rescue: RELs, apoptosis and cellular transformation

1999 • 276 citations

Mitogen-activated Protein Kinase/ERK Kinase Kinases 2 and 3 Activate Nuclear Factor-κB through IκB Kinase-α and IκB Kinase-β

1999 • 274 citations

Activator protein 1 (AP-1)– and nuclear factor κB (NF-κB)–dependent transcriptional events in carcinogenesis

2000 • 265 citations

Gene microarray identification of redox and mitochondrial elements that control resistance or sensitivity to apoptosis

2000 • 259 citations

Oxidative stress interference with the nuclear factor- κB activation pathways

2000 • 243 citations

Coordinate Regulation of IκB Kinases by Mitogen-Activated Protein Kinase Kinase Kinase 1 and NF-κB-Inducing Kinase

1998 • 228 citations

Ikappa Balpha is a target for the mitogen-activated 90kDa ribosomal S6 kinase

1997 • 225 citations

BCL-2 and glutathione: alterations in cellular redox state that regulate apoptosis sensitivity

1999 • 222 citations

Shift of the Cellular Oxidation‐Reduction Potential in Neural Cells Expressing Bcl‐2

1996 • 221 citations

Redox Signals and NF-κB Activation in T Cells

1998 • 206 citations

High Constitutive NF-κB Activity Mediates Resistance to Oxidative Stress in Neuronal Cells

1998 • 189 citations

Bcl‐2 Protects Isolated Plasma and Mitochondrial Membranes Against Lipid Peroxidation Induced by Hydrogen Peroxide and Amyloid β‐Peptide

1998 • 188 citations

Identification of a Putative Antioxidant Response Element in the 5′-Flanking Region of the Human γ-Glutamylcysteine Synthetase Heavy Subunit Gene

1995 • 187 citations

Inhibition of nuclear factor kappa B (NF?B) activity induces nerve growth factor-resistant apoptosis in PC12 cells

1997 • 177 citations

Superoxide-Mediated Cytotoxicity in Superoxide Dismutase-Deficient Fetal Fibroblasts

1997 • 167 citations

Bcl-2 and Bcl-X_L Block Thapsigargin-Induced Nitric Oxide Generation, c-Jun NH₂-Terminal Kinase Activity, and Apoptosis

1999 • 151 citations

Bcl-2 Activates the Transcription Factor NFκB through the Degradation of the Cytoplasmic Inhibitor IκBα

1998 • 144 citations

Redox Regulation of Nuclear Factor Kappa B: Therapeutic Potential for Attenuating Inflammatory Responses

2000 • 142 citations

Apoptosis

1997 • 141 citations

Enhanced Oxidative Stress and Altered Antioxidants in Brains of Bcl‐2‐Deficient Mice

1998 • 138 citations

Long Exposure to High Glucose Concentration Impairs the Responsive Expression of γ-Glutamylcysteine Synthetase by Interleukin-1β and Tumor Necrosis Factor-α in Mouse Endothelial Cells

1996 • 136 citations

Bcl‐2 Protects Neural Cells from Cyanide/Aglycemia‐Induced Lipid Oxidation, Mitochondrial Injury, and Loss of Viability

1995 • 126 citations

PKC‐ and ERK‐dependent activation of IκB kinase by lipopolysaccharide in macrophages: enhancement by P2Y receptor‐mediated CaMK activation

2001 • 126 citations

Effect of overexpression of Bcl-2 on cellular oxidative damage, nitric oxide production, antioxidant defenses, and the proteasome

2001 • 110 citations

Involvement of Hydrogen Peroxide in Topoisomerase Inhibitor β-lapachone-Induced Apoptosis and Differentiation in Human Leukemia Cells

1998 • 106 citations

Activation of NF-κB by Reactive Oxygen Intermediates in the Nervous System

1999 • 106 citations

Bcl-2 inhibits selective oxidation and externalization of phosphatidylserine during paraquat-induced apoptosis

1997 • 98 citations

bcl-2 over-expression enhances NF-?B activity and induces mmp-9 transcription in human MCF7ADR breast-cancer cells

2000 • 97 citations

Bcl-2 Facilitates Recovery from DNA Damage after Oxidative Stress

1999 • 96 citations

Linkage of the BH4 Domain of Bcl-2 and the Nuclear Factor κB Signaling Pathway for Suppression of Apoptosis

1999 • 83 citations

Effect of overexpression of wild‐type and mutant Cu/Zn‐superoxide dismutases on oxidative stress and cell death induced by hydrogen peroxide, 4‐hydroxynonenal or serum deprivation: potentiation of injury by ALS‐related mutant superoxide dismutases and protection by Bcl‐2

2001 • 81 citations

Cloning and characterization of the murine manganous superoxide dismutase-encoding gene

1995 • 76 citations

Study of 5′-Flanking Region of Human Cu/Zn Superoxide Dismutase

1994 • 75 citations

Dual Potential of Extracellular Signal-Regulated Kinase for the Control of Cell Survival

1999 • 73 citations

BCL-2 is involved in preventing oxidant-induced cell death and in decreasing oxygen radical production

2001 • 68 citations

Overproduction of Cu/Zn-Superoxide Dismutase or Bcl-2 Prevents the Brain Mitochondrial Respiratory Dysfunction Induced by Glutathione Depletion

1999 • 67 citations

Potentiation of murine astrocyte antioxidant defence by bcl‐2: protection in part reflects elevated glutathione levels

1998 • 65 citations

Oxidative stress is attenuated in mice overexpressing BCL-2

1999 • 63 citations

IKKβ Is Required for Bcl-2-mediated NF-κB Activation in Ventricular Myocytes

2002 • 61 citations

Bcl-2 Overexpression Increases Survival in Human Retinal Pigment Epithelial Cells Exposed to H2O2

2002 • 55 citations

Overexpression of mitogen-activated protein kinase (ERK1) enhances T- cell cytokine gene expression: role of AP1, NF-AT, and NF-KB

1993 • 54 citations

Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit

2001 • 50 citations

Oxidative Mechanisms in β-Amyloid Cytotoxicity

1996 • 47 citations

6-hydroxydopamine-induced nuclear factor-kappaB activation in PC12 cells22Abbreviations: 6-OHDA, 6-hydroxydopamine; EMSA, electrophoretic mobility shift assay; GSH, glutathione; IAP, inhibitory apoptosis protein; MAP, mitogen-activated protein; NAC, N-acetyl-cystein; NF-κB, nuclear factor-κB; and PD, Parkinson’s disease.

2001 • 44 citations

Nucleotide excision repair capacity is attenuated in human promyelocytic HL60 cells that overexpress BCL2.

1997 • 40 citations

Differential cell death induced by salsolinol with and without copper: possible role of reactive oxygen species.

2001 • 36 citations

Bcl-2 blocks apoptotic signal of transforming growth factor-β in human hepatoma cells

1998 • 35 citations

Cloning and characterization of the 5′-flanking region of the rat glutamate-cysteine ligase catalytic subunit

2001 • 28 citations

RETRACTED: Cloning and Analysis of the Rat Glutamate–Cysteine Ligase Modifier Subunit Promoter

2001 • 17 citations