Oxidative stress is attenuated in mice overexpressing BCL-2

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

The Release of Cytochrome c from Mitochondria: A Primary Site for Bcl-2 Regulation of Apoptosis

1997 • 4,728 citations

Bcl-2 functions in an antioxidant pathway to prevent apoptosis

1993 • 3,465 citations

Bcl-2 inhibition of neural death: decreased generation of reactive oxygen species

1993 • 1,692 citations

Bcl-xL Regulates the Membrane Potential and Volume Homeostasis of Mitochondria

1997 • 1,389 citations

Mitochondrial control of nuclear apoptosis.

1996 • 1,363 citations

Bcl-2 inhibits the mitochondrial release of an apoptogenic protease.

1996 • 1,143 citations

Overexpression of BCL-2 in transgenic mice protects neurons from naturally occurring cell death and experimental ischemia

1994 • 1,106 citations

Investigation of the subcellular distribution of the bcl-2 oncoprotein: residence in the nuclear envelope, endoplasmic reticulum, and outer mitochondrial membranes.

1993 • 1,044 citations

Neurochemical and histologic characterization of striatal excitotoxic lesions produced by the mitochondrial toxin 3-nitropropionic acid

1993 • 1,017 citations

Bcl-xL forms an ion channel in synthetic lipid membranes

1997 • 817 citations

Channel formation by antiapoptotic protein Bcl-2

1997 • 604 citations

Apoptosis induced by withdrawal of interleukin-3 (IL-3) from an IL-3-dependent hematopoietic cell line is associated with repartitioning of intracellular calcium and is blocked by enforced Bcl-2 oncoprotein production.

1993 • 488 citations

Bcl-2: Prolonging Life in a Transgenic Mouse Model of Familial Amyotrophic Lateral Sclerosis

1997 • 482 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates.

1995 • 471 citations

Neural apoptosis

1995 • 464 citations

Bcl-2 potentiates the maximal calcium uptake capacity of neural cell mitochondria.

1996 • 411 citations

Overexpression of Bcl-2 with herpes simplex virus vectors protects CNS neurons against neurological insults in vitro and in vivo

1996 • 311 citations

Resistance to radiation-induced apoptosis in Bcl-2-expressing cells is reversed by depleting cellular thiols

1997 • 223 citations

Shift of the Cellular Oxidation‐Reduction Potential in Neural Cells Expressing Bcl‐2

1996 • 221 citations

Expression of bcl‐2 inhibits necrotic neural cell death

1995 • 216 citations

Energy Metabolism during Apoptosis

1997 • 206 citations

Chronic mitochondrial energy impairment produces selective striatal degeneration and abnormal choreiform movements in primates

1995 • 190 citations

Expression of BCL-2 protein enhances the survival of mouse fibrosarcoid cells in tumor necrosis factor-mediated cytotoxicity.

1993 • 163 citations

3‐Nitropropionic Acid Neurotoxicity Is Attenuated in Copper/Zinc Superoxide Dismutase Transgenic Mice

1995 • 162 citations

INVOLVEMENT OF OXIDATIVE STRESS IN 3-NITROPROPIONIC ACID NEUROTOXICITY

1996 • 146 citations

Bcl‐2 Protects Neural Cells from Cyanide/Aglycemia‐Induced Lipid Oxidation, Mitochondrial Injury, and Loss of Viability

1995 • 126 citations

BCL-2 expression and mitochondrial activity in leukemic cells with different sensitivity to glucocorticoid-induced apoptosis

1994 • 84 citations

Direct Evidence for Antioxidant Effect of Bcl-2 in PC12 Rat Pheochromocytoma Cells

1997 • 83 citations

Evaluation of Sodium 4-Hydroxybenzoate as an Hydroxyl Radical Trap Using Gas Chromatography–Mass Spectrometry and High-Performance Liquid Chromatography with Electrochemical Detection

1996 • 67 citations

Biological Reactions of Peroxynitrite: Evidence for an Alternative Pathway of Salicylate Hydroxylation

1997 • 27 citations