Overexpression of wild-type p53 alters growth and differentiation of normal human keratinocytes but not human papillomavirus-expressing cell lines.

p53 Mutations in Human Cancers

1991 • 8,133 citations

Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours

1992 • 4,648 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

Participation of p53 protein in the cellular response to DNA damage.

1991 • 3,818 citations

Association of Human Papillomavirus Types 16 and 18 E6 Proteins with p53

1990 • 2,587 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

The p53 proto-oncogene can act as a suppressor of transformation

1989 • 2,019 citations

Definition of a consensus binding site for p53

1992 • 2,000 citations

p53 function and dysfunction

1992 • 1,918 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

Construction and applications of a highly transmissible murine retrovirus shuttle vector

1984 • 1,020 citations

Safe and efficient generation of recombinant retroviruses with amphotropic and ecotropic host ranges.

1988 • 908 citations

Adenovirus E1b-58kd tumor antigen and SV40 large tumor antigen are physically associated with the same 54 kd cellular protein in transformed cells

1982 • 883 citations

Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line.

1992 • 871 citations

The state of the p53 and retinoblastoma genes in human cervical carcinoma cell lines.

1991 • 857 citations

Presence of a Potent Transcription Activating Sequence in the p53 Protein

1990 • 811 citations

Wild-type p53 can inhibit oncogene-mediated focus formation.

1989 • 738 citations

Epidermal differentiation: the bare essentials.

1990 • 651 citations

Transcriptional Activation by Wild-Type but Not Transforming Mutants of the p53 Anti-Oncogene

1990 • 644 citations

Wild-type p53 activates transcription in vitro

1992 • 609 citations

Expression of murine epidermal differentiation markers is tightly regulated by restricted extracellular calcium concentrations in vitro.

1989 • 569 citations

Transformation of human fibroblasts and keratinocytes with human papillomavirus type 16 DNA

1987 • 533 citations

Post-transcriptional regulation of glyceraldehyde-3-phosphate-dehydrogenase gene expression in rat tissues

1984 • 486 citations

Wild-type p53 can down-modulate the activity of various promoters.

1991 • 461 citations

Integrated control of growth and differentiation of normal human prokeratinocytes cultured in serum‐free medium: Clonal analyses, growth kinetics, and cell cycle studies

1984 • 414 citations

Structure and evolution of the human involucrin gene

1986 • 393 citations

Human papillomavirus type 16 alters human epithelial cell differentiation in vitro.

1988 • 377 citations

The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells

1992 • 280 citations

Growth suppression induced by wild-type p53 protein is accompanied by selective down-regulation of proliferating-cell nuclear antigen expression.

1991 • 251 citations

Characterization of normal human exocervical epithelial cells immortalized in vitro by papillomavirus types 16 and 18 DNA.

1988 • 200 citations

Human papillomavirus type 16 E6 increases the degradation rate of p53 in human keratinocytes

1992 • 177 citations

The p53 tumor suppressor protein, a modulator of cell proliferation.

1992 • 171 citations

The MCK enhancer contains a p53 responsive element.

1991 • 170 citations

Involvement of wild-type p53 in pre-B-cell differentiation in vitro.

1991 • 168 citations

Integration and Transcription of Human Papillomavirus Type 16 and 18 Sequences in Cell Lines Derived from Cervical Carcinomas

1987 • 134 citations

Altered pattern of growth and differentiation in human keratinocytes infected by simian virus 40.

1979 • 109 citations

Mutant p53 can substitute for human papillomavirus type 16 E6 in immortalization of human keratinocytes but does not have E6-associated trans-activation or transforming activity

1992 • 72 citations

Recombinant retroviruses encoding human papillomavirus type 18 E6 and E7 genes stimulate proliferation and delay differentiation of human keratinocytes early after infection.

1992 • 71 citations

Leukoregulin and gamma-interferon inhibit human papillomavirus type 16 gene transcription in human papillomavirus-immortalized human cervical cells.

1992 • 68 citations

Expression of wild-type p53 in human A673 cells suppresses tumorigenicity but not growth rate.

1991 • 66 citations

Chromosome Observations on Three Epithelial-Cell Cultures Derived From Carcinomas of the Human Cervix<xref ref-type="fn" rid="fn1">2</xref><xref ref-type="fn" rid="fn2">3</xref>

1962 • 66 citations

Restoration of growth potential in paraclones of human keratinocytes by a viral oncogene.

1989 • 59 citations

Characterization of a cell line (SW756) derived from a human squamous carcinoma of the uterine cervix

1982 • 35 citations