TSF1 to TSF6, required for silencing the Saccharomyces cerevisiae GAL genes, are global regulatory genes.

Experiments in molecular genetics

1972 • 28,260 citations

Methods in yeast genetics

1979 • 7,824 citations

Guide to Yeast Genetics and Molecular Biology

1993 • 2,377 citations

Ssn6-Tup1 is a general repressor of transcription in yeast

1992 • 680 citations

A model fungal gene regulatory mechanism: the GAL genes of Saccharomyces cerevisiae

1987 • 676 citations

A regulatory hierarchy for cell specialization in yeast

1989 • 612 citations

Characterization of the yeast SWI1, SWI2, and SWI3 genes, which encode a global activator of transcription

1992 • 596 citations

A GAL10-CYC1 hybrid yeast promoter identifies the GAL4 regulatory region as an upstream site.

1982 • 575 citations

Yeast SNF/SWI transcriptional activators and the SPT/SIN chromatin connection

1992 • 567 citations

Evidence that SNF2/SWI2 and SNF5 activate transcription in yeast by altering chromatin structure.

1992 • 535 citations

Regulation of the Yeast HO Gene

1985 • 526 citations

Distinctly regulated tandem upstream activation sites mediate catabolite repression of the CYC1 gene of S. cerevisiae

1984 • 501 citations

Nucleosome loss activates yeast downstream promoters in vivo

1988 • 456 citations

Five SWI genes are required for expression of the HO gene in yeast

1984 • 450 citations

Saccharomyces cerevisiae GAL1-GAL10 Divergent Promoter Region: Location and Function of the Upstream Activating Sequence UAS_G

1984 • 395 citations

A repressor (MATα2 product) and its operator control expression of a set of cell type specific genes in yeast

1985 • 368 citations

MUTATIONS AFFECTING TY-MEDIATED EXPRESSION OF THE HIS4 GENE OF SACCHAROMYCES CEREVISIAE

1984 • 355 citations

Histone Function in Transcription

1990 • 354 citations

The SIT4 protein phosphatase functions in late G1 for progression into S phase.

1991 • 340 citations

The HOP1 gene encodes a meiosis-specific component of yeast chromosomes

1990 • 325 citations

Family of proteins that interact with TFIID and regulate promoter activity

1991 • 319 citations

An amino-terminal fragment of GAL4 binds DNA as a dimer

1989 • 296 citations

Regulation of yeast mating-type interconversion: feedback control of HO gene expression by the mating-type locus.

1983 • 280 citations

Primary Structure of the Saccharomyces cerevisiae GAL4 Gene

1984 • 276 citations

Changes in histone gene dosage alter transcription in yeast.

1988 • 275 citations

Activation of the yeast HO gene by release from multiple negative controls

1987 • 257 citations

A suppressor of a HIS4 transcriptional defect encodes a protein with homology to the catalytic subunit of protein phosphatases

1989 • 251 citations

SPT15, the gene encoding the yeast TATA binding factor TFIID, is required for normal transcription initiation in vivo

1989 • 239 citations

A yeast protein that influences the chromatin structure of UASG and functions as a powerful auxiliary gene activator.

1990 • 229 citations

Cooperative DNA binding of the yeast transcriptional activator GAL4.

1988 • 227 citations

Characterization of TUP1, a mediator of glucose repression in Saccharomyces cerevisiae.

1990 • 207 citations

Transcriptional Regulation in the Yeast Life Cycle

1987 • 196 citations

Molecular analysis of SSN6, a gene functionally related to the SNF1 protein kinase of Saccharomyces cerevisiae.

1987 • 192 citations

Unlinked noncomplementation: isolation of new conditional-lethal mutations in each of the tubulin genes of Saccharomyces cerevisiae.

1988 • 191 citations

Two systems of glucose repression of the GAL1 promoter in Saccharomyces cerevisiae.

1990 • 178 citations

Both positive and negative regulators of HO transcription are required for mother-cell-specific mating-type switching in yeast

1987 • 171 citations

Involvement of the SIN4 global transcriptional regulator in the chromatin structure of Saccharomyces cerevisiae.

1992 • 162 citations

A Negative Regulator of HO Transcription, SIN1 (SPT2), Is a Nonspecific DNA-Binding Protein Related to HMG1

1991 • 157 citations

MET4, a leucine zipper protein, and centromere-binding factor 1 are both required for transcriptional activation of sulfur metabolism in Saccharomyces cerevisiae.

1992 • 156 citations

RAP1 is required for BAS1/BAS2- and GCN4-dependent transcription of the yeast HIS4 gene.

1991 • 147 citations

GAL11 protein, an auxiliary transcription activator for genes encoding galactose-metabolizing enzymes in Saccharomyces cerevisiae.

1988 • 145 citations

Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast.

1989 • 141 citations

Nondissociation of GAL4 and GAL80 in Vivo After Galactose Induction

1992 • 139 citations

REB1, a yeast DNA-binding protein with many targets, is essential for growth and bears some resemblance to the oncogene myb.

1990 • 134 citations

A NEW MAPPING METHOD EMPLOYING A MEIOTIC REC- MUTANT OF YEAST

1982 • 131 citations

Isolation and analysis of a novel class of suppressor of Ty insertion mutations in Saccharomyces cerevisiae.

1988 • 130 citations

Yeast repressor alpha 2 binds to its operator cooperatively with yeast protein Mcm1.

1989 • 125 citations

GCR1 of Saccharomyces cerevisiae encodes a DNA binding protein whose binding is abolished by mutations in the CTTCC sequence motif.

1991 • 125 citations

The N-terminal TPR region is the functional domain of SSN6, a nuclear phosphoprotein of Saccharomyces cerevisiae.

1990 • 124 citations

Oxygen regulation of anaerobic and aerobic genes mediated by a common factor in yeast.

1984 • 119 citations

A cis-acting element present in multiple genes serves as a repressor protein binding site for the yeast CAR1 gene.

1990 • 116 citations

The CCR4 gene from Saccharomyces cerevisiae is required for both nonfermentative and spt-mediated gene expression.

1990 • 113 citations

Nucleotide sequence and promoter analysis of SPO13, a meiosis-specific gene of Saccharomyces cerevisiae.

1990 • 102 citations

The Saccharomyces cerevisiae SPT13/GAL11 gene has both positive and negative regulatory roles in transcription.

1989 • 101 citations

SSN20 is an essential gene with mutant alleles that suppress defects in SUC2 transcription in Saccharomyces cerevisiae.

1987 • 91 citations

Yeast Gal11 protein mediates the transcriptional activation signal of two different transacting factors, Gal4 and general regulatory factor I/repressor/activator site binding protein 1/translation upstream factor.

1990 • 88 citations

SPT6, an essential gene that affects transcription in Saccharomyces cerevisiae, encodes a nuclear protein with an extremely acidic amino terminus.

1990 • 77 citations

TSF3, a global regulatory protein that silences transcription of yeast GAL genes, also mediates repression by alpha 2 repressor and is identical to SIN4.

1993 • 77 citations

Identification of a Saccharomyces cerevisiae DNA-Binding Protein Involved in Transcriptional Regulation

1990 • 66 citations

GAL1-GAL10 divergent promoter region of Saccharomyces cerevisiae contains negative control elements in addition to functionally separate and possibly overlapping upstream activating sequences.

1987 • 65 citations

In vitro regulation of a SIN3-dependent DNA-binding activity by stimulatory and inhibitory factors.

1990 • 60 citations

Negative control at a distance mediates catabolite repression in yeast

1985 • 54 citations

Opposing regulatory functions of positive and negative elements in UASG control transcription of the yeast GAL genes.

1990 • 43 citations

A nucleosome-positioning sequence is required for GCN4 to activate transcription in the absence of a TATA element.

1990 • 40 citations

Characteristics and Relationships of Mercury-Resistant Mutants and Methionine Auxotrophs of Yeast

1974 • 39 citations

Impact of the Douglas-Hawthorne model as a paradigm for elucidating cellular regulatory mechanisms in fungi.

1991 • 19 citations

Differential repression of GAL4 and adjacent transcription activators by operators in the yeast GAL upstream activating sequence.

1989 • 17 citations

New Amino Acid Regulatory Locus Having Unusual Properties in Heterozygous Merodiploids

1972 • 13 citations

Deleted Work

1955 • 0 citations