Serine Palmitoyltransferase Regulates de NovoCeramide Generation during Etoposide-induced Apoptosis

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 47,127 citations

A RAPID METHOD OF TOTAL LIPID EXTRACTION AND PURIFICATION

1959 • 21,307 citations

Prevention of Apoptosis by Bcl-2: Release of Cytochrome c from Mitochondria Blocked

1997 • 4,921 citations

A Combinatorial Approach Defines Specificities of Members of the Caspase Family and Granzyme B

1997 • 2,054 citations

Specific proteolytic cleavage of poly(ADP-ribose) polymerase: an early marker of chemotherapy-induced apoptosis.

1993 • 1,888 citations

Programmed Cell Death Induced by Ceramide

1993 • 1,779 citations

Fatty acid-induced β cell apoptosis: A link between obesity and diabetes

1998 • 1,142 citations

Inhibition of sphingolipid biosynthesis by fumonisins. Implications for diseases associated with Fusarium moniliforme

1991 • 1,094 citations

Induction of endonucleolytic DNA cleavage in human acute myelogenous leukemia cells by etoposide, camptothecin, and other cytotoxic anticancer drugs: a cautionary note.

1989 • 937 citations

Ceramide synthase mediates daunorubicin-induced apoptosis: An alternative mechanism for generating death signals

1995 • 835 citations

Cleavage of lamin A by Mch2 alpha but not CPP32: multiple interleukin 1 beta-converting enzyme-related proteases with distinct substrate recognition properties are active in apoptosis.

1996 • 529 citations

Nonintercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.

1984 • 491 citations

Zinc Is a Potent Inhibitor of the Apoptotic Protease, Caspase-3

1997 • 486 citations

Thioredoxin Peroxidase Is a Novel Inhibitor of Apoptosis with a Mechanism Distinct from That of Bcl-2

1997 • 372 citations

Sphingomyelin synthesis in rat liver occurs predominantly at the cis and medial cisternae of the Golgi apparatus.

1990 • 369 citations

Fumonisin B1 inhibits sphingosine (sphinganine) N-acyltransferase and de novo sphingolipid biosynthesis in cultured neurons in situ.

1993 • 363 citations

Inhibition of Carnitine Palmitoyltransferase I Augments Sphingolipid Synthesis and Palmitate-induced Apoptosis

1997 • 349 citations

Subcellular localization and membrane topology of serine palmitoyltransferase, 3-dehydrosphinganine reductase, and sphinganine N-acyltransferase in mouse liver.

1992 • 343 citations

Glucosylceramide is synthesized at the cytosolic surface of various Golgi subfractions

1992 • 306 citations

Involvement of Yeast Sphingolipids in the Heat Stress Response of Saccharomyces cerevisiae

1997 • 294 citations

Cell death induced by topoisomerase-targeted drugs: more questions than answers

1998 • 280 citations

Activation of Multiple Interleukin-1β Converting Enzyme Homologues in Cytosol and Nuclei of HL-60 Cells during Etoposide-induced Apoptosis

1997 • 211 citations

Cytokine Response Modifier A (CrmA) Inhibits Ceramide Formation in Response to Tumor Necrosis Factor (TNF)-α: CrmA and Bcl-2 Target Distinct Components in the Apoptotic Pathway

1997 • 210 citations

prICE: a downstream target for ceramide-induced apoptosis and for the inhibitory action of Bcl-2

1996 • 203 citations

Cloning and characterization of LCB1, a Saccharomyces gene required for biosynthesis of the long-chain base component of sphingolipids

1991 • 185 citations

Enzymology of long-chain base synthesis by liver: Characterization of serine palmitoyltransferase in rat liver microsomes

1984 • 182 citations

Involvement of de NovoCeramide Biosynthesis in Tumor Necrosis Factor-α/Cycloheximide-induced Cerebral Endothelial Cell Death

1998 • 182 citations

Identification of a distinct pool of sphingomyelin involved in the sphingomyelin cycle.

1994 • 174 citations

12-O-tetradecanoylphorbol-13-acetate-induced apoptosis in LNCaP cells is mediated through ceramide synthase.

1998 • 139 citations

Ceramide induces apoptosis via CPP32 activation

1996 • 133 citations

Phenotypes of sphingolipid-dependent strains of Saccharomyces cerevisiae

1992 • 105 citations

UVB irradiation up-regulates serine palmitoyltransferase in cultured human keratinocytes

1998 • 87 citations

Reversal of radiation resistance in LNCaP cells by targeting apoptosis through ceramide synthase.

1999 • 79 citations

Sphingolipid biosynthesis in cultured neurons

1991 • 77 citations

Sequential Operation of Ceramide Synthesis and ICE Cascade in CPT-11-Initiated Apoptotic Death Signaling

1997 • 74 citations

Ceramide quantitation: evaluation of a mixed micellar assay using E. coli diacylglycerol kinase.

1995 • 56 citations

The multidrug resistance modulator SDZ PSC 833 is a potent activator of cellular ceramide formation

1998 • 55 citations

Inhibition of serine palmitoyltransferase activity in rabbit aorta by L-cycloserine.

1987 • 25 citations

Activity of 3-ketosphinganine synthase during differentiation and aging of neuronal cells in culture

1997 • 19 citations

[44] Synthesis of key precursors of radiolabeled sphingolipids

2000 • 13 citations