Clinical Significance of Cytogenetic Abnormalities in Adult Acute Lymphoblastic Leukemia

p53 Mutations in Human Cancers

1991 • 8,133 citations

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

A New Consistent Chromosomal Abnormality in Chronic Myelogenous Leukaemia identified by Quinacrine Fluorescence and Giemsa Staining

1973 • 4,217 citations

The p53 tumour suppressor gene

1991 • 3,871 citations

A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma

1986 • 2,968 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

A minute chromosome in human chronic granulocytic leukemia

1960 • 2,329 citations

Wild-type p53 induces apoptosis of myeloid leukaemic cells that is inhibited by interleukin-6

1991 • 2,127 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Suppression of Human Colorectal Carcinoma Cell Growth by Wild-Type p53

1990 • 1,796 citations

The chromosomes in human cancer and leukemia

1990 • 1,780 citations

E2F: a Link Between the Rb Tumor Suppressor Protein and Viral Oncoproteins

1992 • 1,552 citations

Chromosomal translocations in human cancer

1994 • 1,551 citations

Fusion of PDGF receptor β to a novel ets-like gene, tel, in chronic myelomonocytic leukemia with t(5;12) chromosomal translocation

1994 • 1,211 citations

Absence of blood formation in mice lacking the T-cell leukaemia oncoprotein tal-1/SCL

1995 • 961 citations

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The Molecular Genetics of Philadelphia Chromosome–Positive Leukemias

1988 • 867 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

Translocation of c-abl oncogene correlates with the presence of a Philadelphia chromosome in chronic myelocytic leukaemia

1983 • 743 citations

The diversity of BCR-ABL fusion proteins and their relationship to leukemia phenotype [editorial; comment]

1996 • 739 citations

Fusion of the TEL gene on 12p13 to the AML1 gene on 21q22 in acute lymphoblastic leukemia.

1995 • 738 citations

The A.T-DNA-binding domain of mammalian high mobility group I chromosomal proteins. A novel peptide motif for recognizing DNA structure.

1990 • 674 citations

Identification of a gene, MLL, that spans the breakpoint in 11q23 translocations associated with human leukemias.

1991 • 602 citations

Hypermethylation-associated inactivation indicates a tumor suppressor role for p15INK4B.

1996 • 585 citations

Cancer incidence, survival, and mortality for children younger than age 15 years

1986 • 578 citations

Lineage promiscuity in hemopoietic differentiation and leukemia

1986 • 572 citations

TEL/AML1 fusion resulting from a cryptic t(12;21) is the most common genetic lesion in pediatric ALL and defines a subgroup of patients with an excellent prognosis.

1995 • 566 citations

The t(12;21) of acute lymphoblastic leukemia results in a tel-AML1 gene fusion

1995 • 563 citations

Rearrangement of the MLL Gene in Acute Lymphoblastic and Acute Myeloid Leukemias with 11q23 Chromosomal Translocations

1993 • 523 citations

High frequency of t(12;21) in childhood B-lineage acute lymphoblastic leukemia

1995 • 454 citations

Deregulation of a Homeobox Gene, HOX11, by the t(10;14) in T Cell Leukemia

1991 • 411 citations

Homozygous deletion of the alpha- and beta 1-interferon genes in human leukemia and derived cell lines.

1988 • 407 citations

Childhood Leukemias

1995 • 382 citations

Detection of bcr - abl Fusion in Chronic Myelogeneous Leukemia by in Situ Hybridization

1990 • 371 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 354 citations

Incidence and Clinical Relevance of TEL/AML1 Fusion Genes in Children With Acute Lymphoblastic Leukemia Enrolled in the German and Italian Multicenter Therapy Trials

1997 • 326 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 319 citations

Molecular Basis of Human B Cell Neoplasia

1985 • 316 citations

Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

1986 • 308 citations

TEL/AML-1 dimerizes and is associated with a favorable outcome in childhood acute lymphoblastic leukemia

1996 • 306 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Prognostic impact of cytogenetic abnormalities in patients with de novo acute nonlymphocytic leukemia

1989 • 294 citations

Biology and clinical significance of cytogenetic abnormalities in childhood acute lymphoblastic leukemia

1990 • 290 citations

Fusion of the Leucine Zipper Gene HLF to the E2A Gene in Human Acute B-Lineage Leukemia

1992 • 290 citations

The novel activation of ABL by fusion to an ets-related gene, TEL.

1995 • 289 citations

Altered nucleotide sequences of a translocated c-myc gene in Burkitt lymphoma

1983 • 286 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 284 citations

Point mutations in the c–Myc transactivation domain are common in Burkitt's lymphoma and mouse plasmacytomas

1993 • 283 citations

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias [see comments]

1994 • 280 citations

PBX2 and PBX3, new homeobox genes with extensive homology to the human proto-oncogene PBX1.

1991 • 280 citations

A novel c-abl protein product in Philadelphia-positive acute lymphoblastic leukaemia

1987 • 278 citations

Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)

1992 • 276 citations

The chromosomes and causation of human cancer and leukemia.

1966 • 272 citations

Chromosomal Translocations in Lymphoid Malignancies Reveal Novel Proto-Oncogenes

1992 • 267 citations

Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

1990 • 264 citations

The 12;21 translocation involving TEL and deletion of the other TEL allele: two frequently associated alterations found in childhood acute lymphoblastic leukemia

1996 • 258 citations

Philadelphia positive acute lymphoblastic leukemia in adults: age distribution, BCR breakpoint and prognostic significance.

1991 • 251 citations

Cytogenetics adds independent prognostic information in adults with acute lymphoblastic leukaemia on MRC trial UKALL XA

1997 • 247 citations

Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction

1991 • 247 citations

11q23 translocations split the "AT-hook" cruciform DNA-binding region and the transcriptional repression domain from the activation domain of the mixed-lineage leukemia (MLL) gene.

1994 • 241 citations

Prognostic importance of chromosome number in 136 untreated children with acute lymphoblastic leukemia

1982 • 238 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 236 citations

Specific in vivo association between the bHLH and LIM proteins implicated in human T cell leukemia.

1994 • 235 citations

Translocation (12;22) (p13;q11) in myeloproliferative disorders results in fusion of the ETS-like TEL gene on 12p13 to the MN1 gene on 22q11.

1995 • 235 citations

t( 12;21): A new recurrent translocation in acute lymphoblastic leukemia

1994 • 229 citations

Localization of the Estrogen Receptor Locus (ESR) to Chromosome 6q25.1 by FISH and a Simple Post-FISH Banding Technique

1993 • 229 citations

Philadelphia chromosome positive childhood acute lymphoblastic leukemia: clinical and cytogenetic characteristics and treatment outcome. A Pediatric Oncology Group study

1990 • 228 citations

Mutations in the First Exon Are Associated with Altered Transcription of c- myc in Burkitt Lymphoma

1987 • 228 citations

Deletions of Interferon Genes in Acute Lymphoblastic Leukemia

1990 • 221 citations

The biology and treatment of acute lymphoblastic leukemia in adults

1995 • 220 citations

Chromosomal translocations involving the E2A gene in acute lymphoblastic leukemia: clinical features and molecular pathogenesis

1996 • 217 citations

Detection of bcr-abl Transcripts in Philadelphia Chromosome–Positive Acute Lymphoblastic Leukemia After Marrow Transplantation

1997 • 212 citations

TEL gene rearrangement in acute lymphoblastic leukemia: a new genetic marker with prognostic significance.

1997 • 211 citations

Molecular basis of IIq23 rearrangements in hematopoietic malignant proliferations

1995 • 211 citations

Pre-B cell leukemia associated with chromosome translocation 1;19

1984 • 203 citations

Deregulation of c- myc by Translocation of the α-Locus of the T-Cell Receptor in T-Cell Leukemias

1986 • 199 citations

11q23 rearrangements in acute leukemia.

1996 • 197 citations

Cell cycle analysis of p53-induced cell death in murine erythroleukemia cells.

1993 • 196 citations

Prognostic implications of chromosomal findings in acute lymphoblastic leukaemia at diagnosis.

1978 • 195 citations

A direct bone marrow chromosome technique for acute lymphoblastic leukemia

1984 • 193 citations

Chromosomal localization of human leukocyte, fibroblast, and immune interferon genes by means of in situ hybridization

1982 • 192 citations

Cytogenetics of pre-B-cell acute lymphoblastic leukemia with emphasis on prognostic implications of the t(1;19).

1990 • 188 citations

Chromosomes and causation of human cancer and leukemia.XXVI. Banding studies in acute lymphoblastic leukemia (ALL)

1977 • 188 citations

Molecular analysis of deletions of the short arm of chromosome 9 in human gliomas.

1992 • 187 citations

bcr rearrangement and translocation of the c-abl oncogene in Philadelphia positive acute lymphoblastic leukemia

1986 • 186 citations

A novel human homeobox gene lies at the chromosome 10 breakpoint in lymphoid neoplasias with chromosomal translocation t(10;14)

1991 • 186 citations

Second allogeneic marrow transplantation for patients with recurrent leukemia after initial transplant with total-body irradiation-containing regimens.

1993 • 186 citations

Isochromosomes in neoplasia

1994 • 186 citations

Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study

1992 • 184 citations

Analysis of p53 mutations in a large series of lymphoid hematologic malignancies of childhood

1993 • 179 citations

Activation of estrogen receptor transfected into a receptor-negative breast cancer cell line decreases the metastatic and invasive potential of the cells.

1992 • 176 citations

Tumor suppressor genes: the p53 and retinoblastoma sensitivity genes and gene products

1990 • 175 citations

Clinical and biologic hallmarks of the Philadelphia chromosome in childhood acute lymphoblastic leukemia

1987 • 173 citations

Does activation of the TAL1 gene occur in a majority of patients with T- cell acute lymphoblastic leukemia? A pediatric oncology group study

1995 • 163 citations

Lymphoblastic Leukemia with Lymphomatous Features Associated with Abnormalities of the Short Arm of Chromosome 9

1985 • 159 citations

The Gene for Enhancer Binding Proteins E12/E47 Lies at the t(1;19) Breakpoint in Acute Leukemias

1989 • 159 citations

The estrogen receptor CpG island is methylated in most hematopoietic neoplasms.

1996 • 156 citations

New type of Bcr/Abl junction in Philadelphia chromosome-positive chronic myelogenous leukemia

1990 • 154 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 152 citations

p190 BCR-ABL mRNA is expressed at low levels in p210-positive chronic myeloid and acute lymphoblastic leukemias

1996 • 151 citations

Frequent and selective methylation of p15 and deletion of both p15 and p16 in T-cell acute lymphoblastic leukemia.

1997 • 150 citations

Six-year follow-up of the clinical significance of karyotype in acute lymphoblastic leukemia

1989 • 149 citations

Chromosomes in acute leukemia

1979 • 148 citations

p16 gene homozygous deletions in acute lymphoblastic leukemia

1995 • 147 citations

Recurrent chromosomal defects are found in most patients with acute nonlymphocytic leukemia

1984 • 146 citations

A variant translocation places the λ immunoglobulin genes 3′ to the c-myc oncogene in Burkitt's lymphoma

1984 • 145 citations

The second International Workshop on Chromosomes in Leukemia

1980 • 143 citations

Acute lymphoblastic leukemia a comprehensive review with emphasis on biology and therapy

1995 • 141 citations

Cytogenetics of childhood T-cell leukemia

1988 • 135 citations

Site-specific deletions involving the tal-1 and sil genes are restricted to cells of the T cell receptor alpha/beta lineage: T cell receptor delta gene deletion mechanism affects multiple genes.

1993 • 134 citations

Brief Report: Philadelphia Chromosome in Acute Lymphocytic Leukemia

1970 • 133 citations

Significance of the P210 versus P190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia

1991 • 133 citations

Frequent loss of heterozygosity at the TEL gene locus in acute lymphoblastic leukemia of childhood

1995 • 132 citations

Gene encoding the alpha chain of the T-cell receptor is moved immediately downstream of c-myc in a chromosomal 8;14 translocation in a cell line from a human T-cell leukemia.

1986 • 131 citations

The Philadelphia Chromosome (Ph¹) in Adults Presenting with Acute Leukaemia: a Comparison of Ph¹+ and Ph¹‐ Patients*

1977 • 131 citations

Trisomy of leukemic cell chromosomes 4 and 10 identifies children with B-progenitor cell acute lymphoblastic leukemia with a very low risk of treatment failure: a Pediatric Oncology Group study

1992 • 131 citations

Philadelphia-chromosome-positive adult acute lymphocytic leukemia: Characteristics, treatment results, and prognosis in 41 patients

1994 • 130 citations

Inactivation of multiple tumor-suppressor genes involved in negative regulation of the cell cycle, MTS1/p16INK4A/CDKN2, MTS2/p15INK4B, p53, and Rb genes in primary lymphoid malignancies

1996 • 129 citations

Chromosomal Abnormalities and their Clinical Significance in Acute Lymphoblastic Leukemia

1983 • 128 citations

Predictability of the t(1;19)(q23;p13) from surface antigen phenotype: implications for screening cases of childhood acute lymphoblastic leukemia for molecular analysis: a Pediatric Oncology Group study

1993 • 128 citations

Nonrandom involvement of the 12p12 breakpoint in chromosome abnormalities of childhood acute lymphoblastic leukemia

1986 • 127 citations

A cluster of chromosome 11p13 translocations found via distinct D-D and D-D-J rearrangements of the human T cell receptor delta chain gene.

1988 • 127 citations

Quantitative acute leukemia cytogenetics

1992 • 126 citations

A possible subgroup of ALL with 9p−

1983 • 125 citations

Abnormalities of the retinoblastoma gene in the pathogenesis of acute leukemia

1991 • 124 citations

Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation.

1994 • 123 citations

Clinical significance of chromosomal abnormalities in acute lymphoblastic leukemia

1981 • 122 citations

Activation of a translocated c-myc gene: role of structural alterations in the upstream region.

1984 • 122 citations

Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia

1994 • 121 citations

Translocation 4; 11 in acute lymphoblastic leukemia: clinical characteristics and prognostic significance

1982 • 118 citations

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study

1993 • 118 citations

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features

1995 • 114 citations

Immunologic, cytogenetic, and clinical characterization of childhood acute lymphoblastic leukemia with the t(1;19) (q23; p13) or its derivative.

1994 • 113 citations

TEL gene is involved in myelodysplastic syndromes with either the typical t(5;12)(q33;p13) translocation or its variant t(10;12)(q24;p13)

1995 • 112 citations

Loss of the cyclin-dependent kinase 4-inhibitor (p16; MTS1) gene is frequent in and highly specific to lymphoid tumors in primary human hematopoietic malignancies

1995 • 109 citations

Clinical characteristics of infant acute leukemia with or without 11q23 translocations.

1988 • 109 citations

Mutations of the p53 gene in lymphoid leukemia

1991 • 104 citations

TEL and KIP1 define the smallest region of deletions on 12p13 in hematopoietic malignancies

1995 • 103 citations

t(8;14) Translocation in a Burkitt's Type of Lymphoblastic Leukaemia (L3)

1979 • 102 citations

Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia

1996 • 99 citations

Clinical features and outcome of T-cell acute lymphoblastic leukemia in childhood with respect to alterations at the TAL1 locus: a Pediatric Oncology Group study

1993 • 94 citations

TEL‐AML1 fusion in acute lymphoblastic leukaemia of adults

1996 • 94 citations

Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias.

1994 • 94 citations

Case-Control Study Suggests a Favorable Impact of TEL Rearrangement in Patients With B-Lineage Acute Lymphoblastic Leukemia Treated With Antimetabolite-Based Therapy: A Pediatric Oncology Group Study

1997 • 93 citations

Chromosomal abnormalities in acute lymphoblastic leukemia: Structural and numerical changes in 234 cases

1981 • 91 citations

Transcription factors, translocations, and leukemia

1992 • 90 citations

A new translocation, t(10;14)(q24;q11), in T cell neoplasia

1986 • 89 citations

Numerical chromosome aberrations in human neoplasia

1986 • 89 citations

Abnormalities of the short arm of chromosome 9 with partial loss of material in hematological disorders.

1987 • 88 citations

Bone marrow involvement in Burkitt's lymphoma and its relationship to acute B-cell leukemia

1980 • 88 citations

Mutations of the p53 and ras genes in childhood t(1;19)-acute lymphoblastic leukemia

1995 • 86 citations

CHROMOSOME ABNORMALITIES IN HUMAN LEUKEMIA

1980 • 85 citations

Nonhereditary p53 mutations in T-cell acute lymphoblastic leukemia are associated with the relapse phase

1994 • 85 citations

Karyotypic and clinical findings in a consecutive series of children with acute lymphocytic leukemia

1985 • 84 citations

Clinical significance of p53 mutations in newly diagnosed Burkitt's lymphoma and acute lymphoblastic leukemia: a report of 48 cases.

1995 • 83 citations

Prognostic and biological importance of chromosome findings in acute lymphoblastic leukemia

1990 • 80 citations

Mapping chromosomal breakpoints of Burkitt's t(8;14) translocations far upstream of c-myc.

1992 • 80 citations

Cell Cycle and Cancer: Critical Events at the G1 Restriction Point

1996 • 78 citations

Hyperdiploid (47-50) acute lymphoblastic leukemia in children

1992 • 77 citations

TEL/AML1 fusion gene is a rare event in adult acute lymphoblastic leukemia.

1996 • 76 citations

Chromosomes and other prognostic factors in acute lymphoblastic leukaemia: a long‐term follow‐up

1989 • 76 citations

The 1985 human gene map and human gene mapping in 1985

1985 • 75 citations

SIL-TAL1 deletion in T-cell acute lymphoblastic leukemia.

1993 • 75 citations

p16INK4A and p15INK4B gene deletions in primary leukemias

1995 • 75 citations

Immunophenotype-karyotype associations in human acute lymphoblastic leukemia

1989 • 73 citations

The rhombotin gene belongs to a class of transcriptional regulators with a potential novel protein dimerisation motif.

1990 • 72 citations

Pre-pre-B acute lymphoblastic leukemia: high frequency of alternatively spliced ALL1-AF4 transcripts and absence of minimal residual disease during complete remission

1994 • 72 citations

TEL-AML1 translocations with TEL and CDKN2 inactivation in acute lymphoblastic leukemia cell lines

1996 • 72 citations

Double knockout of the ALL-1 gene blocks hematopoietic differentiation in vitro.

1996 • 71 citations

Acute lymphoblastic leukemia and chromosome 21

1997 • 69 citations

How do human isochromosomes arise?

1982 • 69 citations

Burkitt cell acute leukaemia (L₃ ALL) in adults: a report of 18 cases

1989 • 69 citations

Mutations of the p53 gene in B-cell lymphoblastic acute leukemia: a report on 60 cases.

1992 • 68 citations

Common region of deletion on the long arm of chromosome 6 in non‐Hodgkin's lymphoma and acute lymphoblastic leukaemia

1994 • 67 citations

Chromosomes and causation of human cancer and leukemia.XXIII. Near-haploidy in acute leukemia

1977 • 67 citations

Mutational analysis of the candidate tumor suppressor genes TEL and KIP1 in childhood acute lymphoblastic leukemia.

1996 • 67 citations

Loss of heterozygosity in the chromosomal region 12p12-13 is very common in childhood acute lymphoblastic leukemia and permits the precise localization of a tumor-suppressor gene distinct from p27KIP1

1995 • 65 citations

Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review.

1993 • 64 citations

Immunophenotype-karyotype associations in human acute lymphoblastic leukemia

1989 • 64 citations

p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia

1995 • 61 citations

Disruption of the SCL gene by a t(1;3) translocation in a patient with T cell acute lymphoblastic leukemia.

1992 • 61 citations

The 2p breakpoint of a 2;8 translocation in Burkitt lymphoma interrupts the V kappa locus.

1984 • 61 citations

Correlation between theETV6/CBFA2 (TEL/AMLI) fusion gene and karyotypic abnormalities in children with B-cell precursor acute lymphoblastic leukemia

1996 • 60 citations

Assignment of the gene for methylthioadenosine phosphorylase to human chromosome 9 by mouse-human somatic cell hybridization.

1984 • 59 citations

The importance of cytogenetic studies in adult acute lymphocytic leukemia

1990 • 57 citations

Trisomy 4: An entity within acute nonlymphocytic leukemia

1987 • 57 citations

Molecular analysis of the t(1;19) breakpoint cluster region in pre‐b cell acute lymphoblastic leukemias

1990 • 56 citations

Clinical significance of TAL1 gene alteration in childhood T-cell acute lymphoblastic leukemia and lymphoma.

1993 • 55 citations

Transcriptional Activity of TAL1 in T Cell Acute Lymphoblastic Leukemia (T-ALL) Requires RBTN1 or −2 and Induces TALLA1, a Highly Specific Tumor Marker of T-ALL

1997 • 52 citations

A novel variant of the bcr-abl fusion product in Philadelphia chromosome-positive acute lymphoblastic leukemia.

1990 • 52 citations

Abnormalities of chromosome No. 1: Significance in malignant transformation

1978 • 51 citations

Primary, single, autosomal trisomies associated with haematological disorders

1992 • 51 citations

tdic(9;12): a nonrandom chromosome abnormality in childhood B-cell precursor acute lymphoblastic leukemia: a Pediatric Oncology Group Study

1987 • 50 citations

Refined mapping of genomic rearrangements involving the short arm of chromosome 9 in acute lymphoblastic leukemias and other hematologic malignancies

1995 • 50 citations

The TEL Gene Contributes to the Pathogenesis of Myeloid and Lymphoid Leukemias by Diverse Molecular Genetic Mechanisms

1997 • 49 citations

Trisomy 21 as the sole acquired chromosomal abnormality in children with acute lymphoblastic leukemia.

1992 • 46 citations

Isochromosomes in childhood acute lymphoblastic leukemia: a collaborative study of 83 cases

1992 • 46 citations

Cytogenetic Abnormalities in Childhood Acute Lymphoblastic Leukemia Correlates with Clinical Features and Treatment Outcome

1992 • 45 citations

The Third International Workshop on Chromosomes in Leukemia

1981 • 45 citations

The fusion of TEL and ABL in human acute lymphoblastic leukaemia is a rare event

1995 • 45 citations

Molecular biology of acute lymphocytic leukemia.

1997 • 45 citations

Analysis of chromosome 6 deletions in lymphoid malignancies provides evidence for a region of minimal deletion within a 2-megabase segment of 6q21.

1997 • 44 citations

Isochromosome 17q in childhood acute lymphoblastic leukemia: an adverse cytogenetic feature in association with hyperdiploidy?

1988 • 42 citations

Complete or partial trisomy for the long arm of chromosome 1 in patients with various hematologic malignancies

1983 • 42 citations

Deletion of a common region on the long arm of chromosome 6 in acute lymphoblastic leukaemia

1994 • 42 citations

Delineation of a 6 cM commonly deleted region in childhood acute lymphoblastic leukemia on the 6q chromosomal arm

1997 • 41 citations

Molecular analysis of chromosome 22 breakpoints in adult Philadelphia-positive acute lymphoblastic leukaemia

1987 • 40 citations

Clinical and biological heterogeneity of childhood B cell acute lymphocytic leukemia: implications for clinical trials.

1990 • 40 citations

The localization of the HRX/ALL1 protein to specific nuclear subdomains is altered by fusion with its eps15 translocation partner.

1997 • 40 citations

Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11).

1994 • 40 citations

Philadelphia-positive acute leukemia

1990 • 40 citations

Cytogenetics and their prognostic value in childhood and adult acute lymphoblastic leukemia (ALL) excluding L₃

1989 • 39 citations

Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia.

1993 • 39 citations

Balanced and unbalanced 1;19 translocation-associated acute lymphoblastic leukemias

1986 • 38 citations

Isochromosome not translocation in trisomy 21q21q

1989 • 38 citations

Isochromosomes in acute lymphoblastic leukaemia: I(21q) is a significant finding

1996 • 37 citations

Dicentric (9;12) in acute lymphocytic leukemia and other hematological malignancies: report from a dic(9;12) study group.

1995 • 37 citations

The non-random dic(9;12) translocation in acute lymphoblastic leukemia is associated with B-progenitor phenotype and an excellent prognosis.

1992 • 36 citations

Expression of the E2A-PBX1 fusion transcripts in t(1;19)(q23;p13) and der(19)t(1;19) at diagnosis and in remission of acute lymphoblastic leukemia with different B lineage immunophenotypes.

1995 • 35 citations

Methylthioadenosine phosphorylase deficiency in acute leukemia: pathologic, cytogenetic, and clinical features

1988 • 35 citations

Cytogenetic studies in 30 patients with Burkitt's lymphoma or L3 acute lymphoblastic leukemia with special reference to additional chromosome abnormalities.

1989 • 35 citations

Homozygous MTS1 (p16INK4A) deletion in primary tumor cells of 163 leukemic patients [letter; comment]

1995 • 34 citations

Outcome and lineage involvement in t(12;21) childhood acute lymphoblastic leukaemia

1997 • 34 citations

A t(8;14)(q24;q11) translocation in a T‐cell leukemia (L1‐all) with c‐myc and TcR‐alpha chain locus rearrangements

1986 • 34 citations

Detection of the Philadelphia chromosome in acute lymphoblastic leukemia by pulsed-field gel electrophoresis

1989 • 33 citations

Molecular Diagnosis and Clinical Relevance of t(9;22), t(4;ll) and t(l;19) Chromosome Abnormalities in a Consecutive Group of 141 Adult Patients with Acute Lymphoblastic Leukemia

1996 • 33 citations

The Third International Workshop on Chromosomes in Leukemia. Lund, Sweden, July 21-25, 1980. Introduction.

1981 • 33 citations

Tumor suppressor gene alteration in adult acute lymphoblastic leukemia (ALL). Analysis of retinoblastoma (Rb) and p53 gene expression in lymphoblasts of patients with de novo, relapsed, or refractory ALL treated in Southwest Oncology Group studies.

1996 • 32 citations

Cytogenetic Abnormalities in Childhood Acute Lymphoblastic Leukemia

1991 • 31 citations

Translocations involving 9p and/or 12p in acute lymphoblastic leukemia

1992 • 30 citations

Homozygous MTS1 (p16INK4A) deletion in primary tumor cells of 163 leukemic patients.

1995 • 29 citations

Acute lymphocytic leukemia with 9p anomalies

1988 • 29 citations

Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia

1992 • 28 citations

Molecular Cytogenetics of t(12;21)(p13;q22)

1996 • 28 citations

Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)

1992 • 27 citations

PH Positive Acute Lymphoblastic Leukemia in Adults: Molecular and Clinical Studies

1995 • 27 citations

Unexpected heterogeneity in E2A/PBX1 fusion messenger RNA detected by the polymerase chain reaction in pediatric patients with acute lymphoblastic leukemia

1992 • 26 citations

4;11 translocation-associated acute leukemia: A comprehensive analysis☆

1986 • 26 citations

p16^ink4aGene and Hematological Malignancies

1996 • 26 citations

Biallelic alterations of both ETV6 and CDKN1B genes in a t(12;21) childhood acute lymphoblastic leukemia case.

1996 • 25 citations

Chromosomal Abnormalities in Adult Acute Lymphoblastic Leukemia: Results of the German ALL/AUL Study Group

1993 • 24 citations

Ph-chromosome positive acute leukemias and acute phase CML: One or two diseases? Two

1990 • 24 citations

Role of the p53 tumor suppressor gene in the pathogenesis and in the suppression of acute lymphoblastic T-cell leukemia.

1992 • 21 citations

Rearrangements of the MLL gene in therapy-related acute myeloid leukemia in patients previously treated with agents targeting DNA- topoisomerase II

1993 • 20 citations

p53 gene inactivation in acute lymphoblastic leukemia of B cell lineage associates with chromosomal breakpoints at 11q23 and 8q24.

1995 • 20 citations

Detection of MLL gene rearrangements in adult acute lymphoblastic leukemia. A Cancer and Leukemia Group B study.

1994 • 19 citations

Molecular variants of the 1;19 chromosomal translocation in pediatric acute lymphoblastic leukemia (ALL).

1994 • 19 citations

CDKN2 gene deletion is not found in chronic lymphoid leukaemias of B‐ and T‐cell origin but is frequent in acute lymphoblastic leukaemia

1995 • 19 citations

Trisomy 8 in acute lymphoblastic leukemia (ALL): a case report and update of the literature.

1990 • 19 citations

The Central Galaxy in Abell 2029: An Old Supergiant

1990 • 19 citations

Cell cycle regulation and human leukemias: the role of p16INK4 gene inactivation in the development of human acute lymphoblastic leukemia.

1995 • 18 citations

Incidence and Clinical Relevance of TEL/AML1 Fusion Genes in Children With Acute Lymphoblastic Leukemia Enrolled in the German and Italian Multicenter Therapy Trials

1997 • 18 citations

Molecular basis of human B cell neoplasia

1985 • 18 citations

Low incidence of TAL1 gene rearrangements in adult acute lymphoblastic leukemia: A cancer and leukemia group B study (8762)

1995 • 17 citations

11q23 Aberration is an additional chromosomal change in de novo acute leukemia after treatment with etoposide and mitoxantrone

1996 • 16 citations

Trisomy 5 as sole anomaly in acute lymphoblastic leukemia

1988 • 16 citations

Characterization of translocation t(1;14)(p32;q11) in a T and in a B acute leukemia.

1993 • 16 citations

Presenting characteristics of trisomy 8 as the primary cytogenetic abnormality associated with childhood acute lymphoblastic leukemia

1994 • 15 citations

Trisomy 4 may occur in a broad range of hematologic malignancies

1993 • 14 citations

Cytogenetic Abnormalities in Childhood Acute Lymphoblastic Leukemia

1993 • 13 citations

Large-scale molecular mapping of human c-myb locus: c-myb proto-oncogene is not involved in 6q- abnormalities of lymphoid tumors.

1992 • 13 citations

Immunophenotypic and Immunogenotypic Detection of Minimal Residual Disease in Acute Lymphoblastic Leukemia

1993 • 12 citations

Trisomy 5 as the sole abnormality in acute lymphoblastic leukemia

1994 • 12 citations

Monosomy 20: A nonrandom finding in childhood acute lymphoblastic leukemia

1990 • 12 citations

Trisomy 4 in a case of acute lymphocytic leukemia (L1)

1992 • 11 citations

Clinical implications of cytogenetic and molecular analyses of pediatric acute lymphoblastic leukemia

1993 • 10 citations

Detection of minimal residual disease in ALL

1993 • 10 citations

Clinical implications of cytogenetic classification in adult acute lymphoblastic leukaemia patients

1996 • 10 citations

Trisomy 4 in acute myeloblastic and acute lymphoblastic leukemia

1993 • 9 citations

Cytogenetic studies on patients of acute lymphoblastic leukemia Burkitt's type with (8;14) & (14;18) translocations.

1994 • 9 citations

Monosomy 20 in childhood acute lymphoblastic leukemia

1992 • 8 citations

Clinical significance of p53 mutations in relapsed T-cell acute lymphoblastic leukemia

1994 • 7 citations

Significance of the P210 versus P190 molecular abnormalities in adults with Philadelphia chromosome-positive acute leukemia

1991 • 7 citations

Large-scale molecular mapping of human c-myb locus: c-myb proto-oncogene is not involved in 6q- abnormalities of lymphoid tumors.

1992 • 6 citations

Deleted Work

1955 • 0 citations