Multiple tumor-suppressor gene 1 inactivation is the most frequent genetic alteration in T-cell acute lymphoblastic leukemia

Proposals for the Classification of the Acute Leukaemias F<scp>rench</scp>‐A<scp>merican</scp>‐B<scp>ritish</scp> (FAB) C<scp>o‐operative</scp> G<scp>roup</scp>

1976 • 5,620 citations

A new regulatory motif in cell-cycle control causing specific inhibition of cyclin D/CDK4

1993 • 3,680 citations

Inhibitors of mammalian G1 cyclin-dependent kinases.

1995 • 3,258 citations

A Cell Cycle Regulator Potentially Involved in Genesis of Many Tumor Types

1994 • 2,821 citations

Cyclins and cancer II: Cyclin D and CDK inhibitors come of age

1994 • 2,122 citations

5′ CpG island methylation is associated with transcriptional silencing of the tumour suppressor p16/CDKN2/MTS1 in human cancers

1995 • 2,000 citations

pl5INK4B is a potentia| effector of TGF-β-induced cell cycle arrest

1994 • 1,932 citations

Deletions of the cyclin-dependent kinase-4 inhibitor gene in multiple human cancers

1994 • 1,806 citations

Alternative reading frames of the INK4a tumor suppressor gene encode two unrelated proteins capable of inducing cell cycle arrest

1995 • 1,500 citations

Frequent somatic mutations and homozygous deletions of the p16 (MTS1) gene in pancreatic adenocarcinoma

1994 • 1,142 citations

Role of the cyclin-dependent kinase inhibitors in the development of cancer

1995 • 404 citations

Complex structure and regulation of the P16 (MTS1) locus.

1995 • 402 citations

Differentiation-Linked Leukemogenesis in Lymphocytes

1986 • 359 citations

A novel p16INK4A transcript.

1995 • 348 citations

Candidate tumor-suppressor genes MTS1 (p16INK4A) and MTS2 (p15INK4B) display frequent homozygous deletions in primary cells from T- but not from B-cell lineage acute lymphoblastic leukemias [see comments]

1994 • 280 citations

Frequent deletion of p16INK4a/MTS1 and p15INK4b/MTS2 in pediatric acute lymphoblastic leukemia

1995 • 199 citations

Homozygous loss of the cyclin-dependent kinase 4-inhibitor (p16) gene in human leukemias

1994 • 164 citations

Lymphoblastic Leukemia with Lymphomatous Features Associated with Abnormalities of the Short Arm of Chromosome 9

1985 • 159 citations

Analysis of a family of cyclin-dependent kinase inhibitors: p15/MTS2/INK4B, p16/MTS1/INK4A, and p18 genes in acute lymphoblastic leukemia of childhood

1995 • 158 citations

p16 gene homozygous deletions in acute lymphoblastic leukemia

1995 • 147 citations

A new type of p16INK4/MTS1 gene transcript expressed in B-cell malignancies.

1995 • 135 citations

Prethymic phenotype and genotype of pre-T (CD7+/ER-)-cell leukemia and its clinical significance within adult acute lymphoblastic leukemia [see comments]

1989 • 126 citations

A possible subgroup of ALL with 9p−

1983 • 125 citations

Clinical features and outcome in childhood T-cell leukemia-lymphoma according to stage of thymocyte differentiation: a Pediatric Oncology Group Study

1988 • 118 citations

Detection of homozygous deletions of the cyclin-dependent kinase 4 inhibitor (p16) gene in acute lymphoblastic leukemia and association with adverse prognostic features

1995 • 114 citations

Deletions and rearrangement of CDKN2 in lymphoid malignancy

1995 • 113 citations

Mutational effects on the p16INK4a tumor suppressor protein.

1995 • 96 citations

Homozygous deletions of p16/MTS1 gene are frequent but mutations are infrequent in childhood T-cell acute lymphoblastic leukemia

1995 • 89 citations

p16INK4A and p15INK4B gene deletions in primary leukemias

1995 • 75 citations

p15ink4B and p16ink4 gene inactivation in acute lymphocytic leukemia

1995 • 61 citations

Immunological typing of acute lymphoblastic leukemia: Concurrent analysis by flow cytofluorometry and immunocytology

1986 • 31 citations

Alterations of cyclin-dependent kinase 4 inhibitor (p16INK4A/MTS1) gene structure and expression in acute lymphoblastic leukemias.

1995 • 23 citations

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