Molecular Diagnosis and Clinical Relevance of t(9;22), t(4;ll) and t(l;19) Chromosome Abnormalities in a Consecutive Group of 141 Adult Patients with Acute Lymphoblastic Leukemia

Involvement of a homolog of Drosophila trithorax by 11q23 chromosomal translocations in acute leukemias

1992 • 944 citations

The t(4;11) chromosome translocation of human acute leukemias fuses the ALL-1 gene, related to Drosophila trithorax, to the AF-4 gene

1992 • 850 citations

A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B all

1990 • 726 citations

Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor

1990 • 692 citations

Chromosomal abnormalities identify high-risk and low-risk patients with acute lymphoblastic leukemia

1986 • 308 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 294 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 284 citations

Clinical significance of the BCR-ABL fusion gene in adult acute lymphoblastic leukemia: a Cancer and Leukemia Group B Study (8762)

1992 • 276 citations

Treatment of Acute Lymphoblastic Leukemia -- 30 Years' Experience at St. Jude Children's Research Hospital

1993 • 272 citations

Poor prognosis of children with pre-B acute lymphoblastic leukemia is associated with the t(1;19)(q23;p13): a Pediatric Oncology Group study

1990 • 264 citations

Detection of chimeric BCR-ABL genes in acute lymphoblastic leukaemia by the polymerase chain reaction

1991 • 247 citations

Molecular rearrangements on chromosome 11q23 predominate in infant acute lymphoblastic leukemia and are associated with specific biologic variables and poor outcome

1993 • 236 citations

Current status of cytogenetic research in childhood acute lymphoblastic leukemia

1993 • 223 citations

The t(1;19)(q23;p13) results in consistent fusion of E2A and PBX1 coding sequences in acute lymphoblastic leukemias

1991 • 218 citations

A cause-specific hazard rate analysis of prognostic factors among 199 adults with acute lymphoblastic leukemia: the Memorial Hospital experience since 1969.

1988 • 177 citations

Different molecular consequences of the 1;19 chromosomal translocation in childhood B-cell precursor acute lymphoblastic leukemia

1992 • 127 citations

Frequent latent Epstein-Barr virus infection of neoplastic T cells and bystander B cells in human immunodeficiency virus-negative European peripheral pleomorphic T-cell lymphomas

1993 • 122 citations

Detection of ALL-1/AF4 fusion transcript by reverse transcription- polymerase chain reaction for diagnosis and monitoring of acute leukemias with the t(4;11) translocation

1993 • 108 citations

The der(11)-encoded MLL/AF-4 fusion transcript is consistently detected in t(4;11)(q21;q23)-containing acute lymphoblastic leukemia

1994 • 84 citations

Prognostic significance of the balanced t(1;19) and unbalanced der(19)t(1;19) translocations in acute lymphoblastic leukemia.

1992 • 84 citations

Detection of BCR-ABL fusion genes in adult acute lymphoblastic leukemia by the polymerase chain reaction.

1994 • 66 citations

Prognostic implications of breakpoint and lineage heterogeneity in Philadelphia-positive acute lymphoblastic leukemia: a review.

1993 • 64 citations

The importance of cytogenetic studies in adult acute lymphocytic leukemia

1990 • 57 citations

Detection and clinical relevance of genetic abnormalities in pediatric acute lymphoblastic leukemia: a comparison between cytogenetic and polymerase chain reaction analyses.

1993 • 43 citations

Detection of HRX-FEL fusion transcripts in pre-pre-B-ALL with and without cytogenetic demonstration of t(4;11).

1994 • 40 citations

Detection and significance of bcr-abl mRNA transcripts and fusion proteins in Philadelphia-positive adult acute lymphoblastic leukemia.

1993 • 39 citations

Heterogeneity in MLL/AF-4 fusion messenger RNA detected by the polymerase chain reaction in t(4;11) acute leukemia.

1993 • 38 citations

Adult Philadelphia-chromosome-positive acute lymphoblastic leukemia: experience of treatments during a ten-year period.

1994 • 36 citations

Treatment of adult acute lymphoblastic leukaemia (ALL) over a 16 year period.

1992 • 31 citations

Intensive therapy for adult acute lymphoblastic leukemia: preliminary results of the idarubicin/vincristine/L-asparaginase/prednisolone regimen.

1993 • 19 citations

ACUTE LYMPHOBLASTIC LEUKAEMIA IN ADULTS: THE CASE FOR A STRATEGIC SHIFT IN STUDY APPROACH

1994 • 14 citations

What is the contribution of molecular studies to the diagnosis of BCR-ABL-positive disease in adult acute leukemia?

1994 • 12 citations

Reinforced HEAV'D therapy for adult acute lymphoblastic leukemia: Improved results and revised prognostic criteria

1993 • 11 citations

THE CHALLENGE OF ACIJTE LYMPHOBLASTIC LEIIKAEMIA IN ADULTS

1993 • 7 citations