Prevention of diabetes in nonobese diabetic mice by anti-I-A monoclonal antibodies: transfer of protection by splenic T cells.

HLA-DQβ gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus

1987 • 2,045 citations

Breeding of a Non-Obese, Diabetic Strain of Mice

1980 • 1,255 citations

Antigen-inducible, H-2-restricted, interleukin-2-producing T cell hybridomas. Lack of independent antigen and H-2 recognition

1981 • 1,048 citations

Properties of Monoclonal Antibodies to Mouse Ig Allotypes, H-2, and Ia Antigens

1979 • 993 citations

Hybridoma cell lines secreting monoclonal antibodies to mouse H-2 and Ia antigens.

1980 • 850 citations

Syngeneic transfer of autoimmune diabetes from diabetic NOD mice to healthy neonates. Requirement for both L3T4+ and Lyt-2+ T cells.

1987 • 576 citations

Both the Lyt-2+ and L3T4+ T cell subsets are required for the transfer of diabetes in nonobese diabetic mice.

1988 • 455 citations

The NOD Mouse: Recessive Diabetogenic Gene in the Major Histocompatibility Complex

1986 • 424 citations

The first external domain of the nonobese diabetic mouse class II I-A beta chain is unique.

1987 • 402 citations

Transfer of Autoimmune Diabetes Mellitus with Splenocytes from Nonobese Diabetic (NOD) Mice

1986 • 371 citations

Three Recessive Loci Required for Insulin-Dependent Diabetes in Nonobese Diabetic Mice

1987 • 293 citations

Predominance of T lymphocytes in pancreatic islets and spleen of pre-diabetic non-obese diabetic (NOD) mice: a longitudinal study.

1985 • 237 citations

Promotion of spontaneous diabetes in non-obese diabetes-prone mice by cyclophosphamide

1984 • 220 citations

Preventive Effect of Monoclonal Anti-L3T4 Antibody on Development of Diabetes in NOD Mice

1987 • 216 citations

Treatment of (NZB x NZW)F1 disease with anti-I-A monoclonal antibodies.

1983 • 208 citations

Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function.

1985 • 191 citations

In vivo therapy with monoclonal anti-I-A antibody suppresses immune responses to acetylcholine receptor

1983 • 165 citations

Anti I-A antibody suppresses active encephalomyelitis: treatment model for diseases linked to IR genes.

1983 • 160 citations

Preventive effects of Cyclosporin on diabetes in NOD mice

1986 • 155 citations

Autoimmune Diabetes in NOD Mouse Is L3T4 T-Lymphocyte Dependent

1987 • 115 citations

Type II collagen-induced arthritis in mice. III. Suppression of arthritis by using monoclonal and polyclonal anti-Ia antisera.

1985 • 91 citations

In vivo prevention of thyroid and pancreatic autoimmunity in the BB rat by antibody to class II major histocompatibility complex gene products.

1985 • 79 citations

Early development of the T cell repertoire. In vivo treatment of neonatal mice with anti-Ia antibodies interferes with differentiation of I-restricted T cells but not K/D-restricted T cells.

1983 • 74 citations

Conversion of immunity to suppression by in vivo administration of I-A subregion-specific antibodies.

1982 • 73 citations

In vivo effects of antibodies to immune response gene products. I. Haplotype-specific suppression of humoral immune responses with a monoclonal anti-I-A.

1981 • 60 citations

Expression of class II major histocompatibility complex antigens on pancreatic B cells in the NOD mouse

1987 • 53 citations

Disappearance and reappearance of B cells after in vivo treatment with monoclonal anti-I-A antibodies.

1984 • 42 citations

Monoclonal antibodies reacting with murine teratocarcinoma cells.

1979 • 41 citations

Participation of suppressor T cells in the immunosuppressive activity of a heteroantiserum to human Ia-like antigens (p23,30).

1980 • 40 citations

In vivo treatment with monoclonal anti-I-A antibodies: disappearance of splenic antigen-presenting cell function concomitant with modulation of splenic cell surface I-A and I-E antigens.

1985 • 39 citations

Genetic control of the immune response to myoglobins. IV. Inhibition of determinant-specific Ir gene-controlled antigen presentation and induction of suppression by pretreatment of presenting cells with anti-Ia antibodies.

1981 • 39 citations

Class-II and IL 2 receptor positive cells in the pancreas of NOD mice

1987 • 36 citations

Regulation of immune response to tumor antigen: interference with syngeneic tumor immunity by anti-IA alloantisera.

1979 • 33 citations

Neonatal suppression with anti-Ia antibody. I. Suppression of murine B lymphocyte development.

1982 • 23 citations

Regulation of transplantation immunity in vivo by monoclonal antibodies recognizing host class II restriction elements. I. Genetics and specificity of anti-Ia immunotherapy in murine skin allograft recipients.

1985 • 19 citations

In vivo administration of anti-I-A antibody induces the internalization of B cell surface I-A and I-E without affecting the expression of surface immunoglobulin.

1984 • 19 citations

Antigen-specific human T lymphocyte clones: mechanisms of inhibition of proliferative responses by xenoantiserum to human nonpolymorphic HLA-DR antigens.

1982 • 16 citations

Regulation of transplantation immunity in vivo by monoclonal antibodies recognizing host class II restriction elements. II. Effects of anti-Ia immunotherapy on host T cell responses to graft alloantigens.

1985 • 10 citations

INDUCTION OF SUPPRESSOR T CELLS BY INTRAVENOUS ADMINISTRATION OF MONOCLONAL ANTI-I-A ANTIBODY

1987 • 8 citations