Transformation of Chicken Embryo Fibroblast Cells by Avian Retroviruses Containing the Human Fyn Gene and Its Mutated Genes

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Improved M13 phage cloning vectors and host strains: nucleotide sequences of the M13mpl8 and pUC19 vectors

1985 • 15,222 citations

The Protein Kinase Family: Conserved Features and Deduced Phylogeny of the Catalytic Domains

1988 • 5,115 citations

Human epidermal growth factor receptor cDNA sequence and aberrant expression of the amplified gene in A431 epidermoid carcinoma cells

1984 • 2,762 citations

[1] Production of single-stranded plasmid DNA

1987 • 2,642 citations

Preparative and analytical purification of DNA from agarose.

1979 • 1,585 citations

A novel viral oncogene with structural similarity to phospholipase C

1988 • 789 citations

Cloning of bovine GAP and its interaction with oncogenic ras p21

1988 • 666 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

A v-erbB-related protooncogene, c-erbB-2, is distinct from the c-erbB-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma.

1985 • 607 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Sequence similarity of phospholipase C with the non-catalytic region of src

1988 • 541 citations

Alternative splicing of RNAs transcribed from the human abl gene and from the bcr-abl fused gene

1986 • 489 citations

New procedure for DNA transfection with polycation and dimethyl sulfoxide.

1984 • 481 citations

A Noncatalytic Domain Conserved among Cytoplasmic Protein-Tyrosine Kinases Modifies the Kinase Function and Transforming Activity of Fujinami Sarcoma Virus P130^gag-fps

1986 • 478 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Activation of pp60c-src protein kinase activity in human colon carcinoma.

1987 • 306 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells.

1987 • 278 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src.

1986 • 257 citations

Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin.

1987 • 253 citations

Non-catalytic domains of cytoplasmic protein-tyrosine kinases: regulatory elements in signal transduction.

1988 • 250 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck.

1987 • 236 citations

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck).

1988 • 232 citations

Inositol phospholipid-specific phospholipase C: complete cDNA and protein sequences and sequence homology to tyrosine kinase-related oncogene products.

1988 • 223 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

New Procedure for DNA Transfection with Polycation and Dimethyl Sulfoxide

1984 • 217 citations

A v-erbB-related protooncogene, c-erb-B-1/epidermal growth factor-receptor gene and is amplified in a human salivary gland adenocarcinoma

1985 • 195 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60^c-src

1985 • 176 citations

Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein.

1986 • 171 citations

Stable Association of Activated pp60^src with Two Tyrosine-Phosphorylated Cellular Proteins

1989 • 168 citations

Primary structure of the brain alpha-spectrin [published erratum appears in J Cell Biol 1989 Mar;108(3):following 1175]

1989 • 164 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

Selective expression of a protein-tyrosine kinase, p56lyn, in hematopoietic cells and association with production of human T-cell lymphotropic virus type I.

1989 • 152 citations

Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.

1986 • 147 citations

Characterization of cDNA clones for the human c-yes gene.

1987 • 147 citations

Phosphorylation of cellular proteins in Rous sarcoma virus-infected cells: analysis by use of anti-phosphotyrosine antibodies.

1988 • 121 citations

Human c-ros-1 Gene Homologous to the v-ros Sequence of UR2 Sarcoma Virus Encodes for a Transmembrane Receptorlike Molecule

1986 • 119 citations

Isolation and Oncogenic Potential of a Novel Human src-Like Gene

1986 • 113 citations

Linker insertion-deletion mutagenesis of the v-src gene: isolation of host- and temperature-dependent mutants

1989 • 107 citations

fgr proto-oncogene mRNA induced in B lymphocytes by Epstein–Barr virus infection

1986 • 97 citations

The common src homology region 2 domain of cytoplasmic signaling proteins is a positive effector of v-fps tyrosine kinase function.

1989 • 96 citations

N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene.

1985 • 88 citations

Acquisition of transforming properties by FYN, a normal SRC-related human gene.

1988 • 87 citations

Activation of pp60c-src transforming potential by mutations altering the structure of an amino terminal domain containing residues 90-95.

1988 • 85 citations

Characterization of avian and viral p60src proteins expressed in yeast.

1987 • 84 citations

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

1982 • 83 citations

Structure, expression, and chromosomal location of the human c-fgr gene.

1986 • 81 citations

Dephosphorylation or Antibody Binding to the Carboxy Terminus Stimulates pp60^c-src

1986 • 80 citations

Characterization of a Rous sarcoma virus mutant defective in packaging its own genomic RNA: biological properties of mutant TK15 and mutant-induced transformants

1984 • 79 citations

Deletions and insertions within an amino-terminal domain of pp60v-src inactivate transformation and modulate membrane stability

1989 • 75 citations

Overexpression of src family gene for tyrosine-kinase p59fyn in CD4-CD8- T cells of mice with a lymphoproliferative disorder.

1989 • 68 citations

Neoplastic Transformation Induced by an Activated Lymphocyte-Specific Protein Tyrosine Kinase (pp56^lck)

1988 • 66 citations

A mutation in v-src that removes a single conserved residue in the SH-2 domain of pp60v-src restricts transformation in a host-dependent manner

1989 • 65 citations

Complete cDNA encoding a putative phospholipase C from transformed human lymphocytes

1988 • 64 citations

Identification of a Human Gene (HCK) that Encodes a Protein-Tyrosine Kinase and is Expressed in Hemopoietic Cells

1987 • 63 citations

Plaque assay for some strains of avian leukosis virus

1972 • 62 citations

Nucleotide sequence and topography of chicken c-fps

1985 • 62 citations

Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein.

1989 • 62 citations

Novel Protein-Tyrosine Kinase Gene (hck) Preferentially Expressed in Cells of Hematopoietic Origin

1987 • 62 citations

The yes-Related Cellular Gene lyn Encodes a Possible Tyrosine Kinase Similar to p56^lck

1987 • 59 citations

Genetic analysis of p60v-src domains involved in the induction of different cell transformation parameters

1986 • 58 citations

Phosphorylation of Cellular Proteins in Rous Sarcoma Virus-Infected Cells: Analysis by Use of Anti-Phosphotyrosine Antibodies

1988 • 54 citations

Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity

1983 • 52 citations

The membrane-binding domain and myristylation of p60v-src are not essential for stimulation of cell proliferation

1987 • 48 citations

Altered Sites of Tyrosine Phosphorylation in pp60^c-src Associated with Polyomavirus Middle Tumor Antigen

1986 • 48 citations

Genetic analysis of the form and function of the viral src oncogene product

1987 • 47 citations

Phosphorylation of tyrosine in the carboxyl-terminal tryptic peptide of pp60c-src.

1986 • 45 citations

N-Terminal Deletions in Rous Sarcoma Virus p60^src: Effects on Tyrosine Kinase and Biological Activities and on Recombination in Tissue Culture with the Cellular src Gene

1985 • 44 citations

Transformation of NIH 3T3 fibroblasts by an activated form of p59hck.

1989 • 42 citations

Identification of an amino terminal domain required for the transforming activity of the Rous sarcoma virus src protein

1987 • 41 citations

Characterization of cDNA Clones for the Human c-yes Gene

1987 • 38 citations

Additional member of the protein-tyrosine kinase family: the src- and lck-related protooncogene c-tkl.

1987 • 34 citations

Hyperproduction of Phosphate‐Binding Protein, phoS, and pre‐phoS Proteins in Escherichia coli Carrying a Cloned phoS Gene

1983 • 34 citations

Avian pp60c-src is more active when expressed in yeast than in vertebrate fibroblasts.

1987 • 28 citations

Isolation and sequencing of cDNA clones homologous to the v-fgr oncogene from a human B lymphocyte cell line, IM-9.

1987 • 23 citations

Structure, Expression, and Chromosomal Location of the Human c-fgr Gene

1986 • 19 citations

Amino Acid Substitutions Sufficient To Convert the Nontransforming p60^c-src Protein to a Transforming Protein

1986 • 18 citations

Deletions within the Amino-Terminal Half of the c-src Gene Product That Alter the Functional Activity of the Protein

1989 • 17 citations

Morphf mutants of Rous sarcoma virus: nucleotide sequencing analysis suggests that a class of morphf mutants was generated through splicing of a cryptic intron

1987 • 15 citations

The Common src Homology Region 2 Domain of Cytoplasmic Signaling Proteins Is a Positive Effector of v-fps Tyrosine Kinase Function

1989 • 15 citations

Structural features of the carboxy terminus of p60c-src that are required for the regulation of its intrinsic kinase activity.

1987 • 12 citations

N-terminal deletion in the src gene of Rous sarcoma virus results in synthesis of a 45,000-Mr protein with mitogenic activity

1987 • 6 citations

Rous sarcoma virus mutant dlPA105 induces different transformed phenotypes in quail embryonic fibroblasts and neuroretina cells

1987 • 5 citations

Modification of carboxyl-terminal region is the cause of activation of the src gene in avian sarcoma virus S2.

1986 • 2 citations