Altered Sites of Tyrosine Phosphorylation in pp60^c-src Associated with Polyomavirus Middle Tumor Antigen

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

[42] Detection and quantification of phosphotyrosine in proteins

1983 • 1,184 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

An activity phosphorylating tyrosine in polyoma T antigen immunoprecipitates

1979 • 540 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Avian sarcoma virus-transforming protein, pp60src shows protein kinase activity specific for tyrosine

1980 • 510 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

Transformation of rat cells by an altered polyoma virus genome expressing only the middle-T protein

1981 • 435 citations

Uninfected vertebrate cells contain a protein that is closely related to the product of the avian sarcoma virus transforming gene (src).

1979 • 378 citations

Characterization of sites for tyrosine phosphorylation in the transforming protein of Rous sarcoma virus (pp60v-src) and its normal cellular homologue (pp60c-src).

1981 • 363 citations

Characterization of Rous sarcoma virus src gene products synthesized in vitro

1978 • 352 citations

Analysis of the sequence of amino acids surrounding sites of tyrosine phosphorylation.

1982 • 337 citations

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

1984 • 333 citations

Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylation

1979 • 319 citations

The protein encoded by the transforming gene of avian sarcoma virus (pp60src) and a homologous protein in normal cells (pp60proto-src) are associated with the plasma membrane.

1980 • 298 citations

The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine.

1980 • 269 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

Characterization of t antigens in polyoma-infected and transformed cells

1978 • 208 citations

The complex of polyoma virus middle-T antigen and pp60c-src.

1984 • 196 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Transduction of a cellular oncogene: the genesis of Rous sarcoma virus.

1983 • 193 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

A normal cell protein similar in structure and function to the avian sarcoma virus transforming gene product.

1979 • 187 citations

Phosphorylation of polyoma T antigens

1979 • 186 citations

Protein kinase activity associated with polyoma virus middle T antigen in vitro

1979 • 174 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Carboxy terminus of polyoma middle-sized tumor antigen is required for attachment to membranes, associated protein kinase activities, and cell transformation.

1982 • 142 citations

Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src

1983 • 138 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase

1981 • 126 citations

The stimulation of pp60v-src kinase activity by vanadate in intact cells accompanies a new phosphorylation state of the enzyme.

1984 • 121 citations

Identification of a Rous sarcoma virus transformation-related protein in normal avian and mammalian cells.

1979 • 112 citations

Viral and cellular src genes contribute to the structure of recovered avian sarcoma virus transforming protein

1981 • 104 citations

Mutation causing premature termination of the polyoma virus medium T antigen blocks cell transformation

1982 • 73 citations

Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen.

1985 • 73 citations

Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family.

1985 • 66 citations

Transmission of the polyoma virus middle T gene as the oncogene of a murine retrovirus

1984 • 59 citations

Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation

1985 • 53 citations

Physical modification of purified rous sarcoma virus pp60v-src protein after incubation with ATP/Mg2+

1983 • 50 citations

Expression of polyoma early gene products inE. coli

1985 • 33 citations

Polyomavirus middle T protein encoded by a retrovirus transforms nonestablished chicken embryo cells

1985 • 28 citations