Genetic analysis of the form and function of the viral src oncogene product

The role of protein kinase C in cell surface signal transduction and tumour promotion

1984 • 7,521 citations

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

PROTEIN-TYROSINE KINASES

1985 • 2,198 citations

Protein kinase C phosphorylation of the EGF receptor at a threonine residue close to the cytoplasmic face of the plasma membrane

1984 • 656 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

The common 90-kd protein component of non-transformed ‘8S’ steroid receptors is a heat-shock protein.

1985 • 527 citations

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

1984 • 447 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

The role of protein phosphorylation in the hormonal control of enzyme activity

1985 • 377 citations

Neurones express high levels of a structurally modified, activated form of pp60c-src

1985 • 372 citations

The specific interaction of the Rous sarcoma virus transforming protein, pp60src, with two cellular proteins

1981 • 360 citations

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation

1984 • 333 citations

Structural analysis of the avian sarcoma virus transforming protein: sites of phosphorylation

1979 • 319 citations

Differentiation of PC12 phaeochromocytoma cells induced by v-src oncogene

1985 • 306 citations

A 90,000-dalton binding protein common to both steroid receptors and the Rous sarcoma virus transforming protein, pp60v-src.

1985 • 304 citations

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

1982 • 294 citations

Neural Tissues Express High Levels of the Cellular src Gene Product pp60^c-src

1983 • 288 citations

Localization of the ASV src gene product to the plasma membrane of transformed cells by electron microscopic immunocytochemistry

1979 • 276 citations

The purified product of the transforming gene of avian sarcoma virus phosphorylates tyrosine.

1980 • 269 citations

Amino Terminal Myristylation of the Protein Kinase p60 src , a Retroviral Transforming Protein

1985 • 264 citations

Protein kinase C phosphorylates pp60src at a novel site

1985 • 243 citations

Comparison of the expression of the src gene of Rous sarcoma virus in vitro and in vivo

1978 • 229 citations

Interaction of the Rous Sarcoma Virus Protein pp60 src with the Cellular Proteins pp50 and pp90

1986 • 223 citations

Myristic acid, a rare fatty acid, is the lipid attached to the transforming protein of Rous sarcoma virus and its cellular homolog

1985 • 223 citations

Rous sarcoma virus transforming protein lacking myristic acid phosphorylates known polypeptide substrates without inducing transformation

1986 • 223 citations

An N-terminal peptide from p60src can direct myristylation and plasma membrane localization when fused to heterologous proteins

1985 • 201 citations

Specificity of inositol trisphosphate-induced calcium release from permeabilized Swiss-mouse 3T3 cells

1984 • 190 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

The control of cellular morphology in embryonic cells infected with Rous sarcoma virus in vitro

1960 • 187 citations

Evidence that the src gene product of rous sarcoma virus is membrane associated

1980 • 180 citations

Neural tissues express high levels of the cellular src gene product pp60c-src.

1983 • 179 citations

Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60^c-src

1985 • 176 citations

The absence of myristic acid decreases membrane binding of p60src but does not affect tyrosine protein kinase activity

1986 • 174 citations

Myristic acid is attached to the transforming protein of Rous sarcoma virus during or immediately after synthesis and is present in both soluble and membrane-bound forms of the protein.

1984 • 173 citations

Regulation of Cell Growth and Transformation by Tyrosine-Specific Protein Kinases: The Search for Important Cellular Substrate Proteins

1983 • 164 citations

Interaction Between the Rous Sarcoma Virus Transforming Protein and Two Cellular Phosphoproteins: Analysis of the Turnover and Distribution of This Complex

1983 • 162 citations

Neither arginine nor histidine can carry out the function of lysine-295 in the ATP-binding site of p60src.

1986 • 156 citations

Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen.

1986 • 147 citations

Phosphorylation of tyrosine-416 is not required for the transforming properties and kinase activity of pp60v-src

1983 • 138 citations

Highly specific antibody to Rous sarcoma virus src gene product recognizes a novel population of pp60v-src and pp60c-src molecules.

1985 • 133 citations

Hormonal regulation of the rous sarcoma virus src gene via a heterologous promoter defines a threshold dose for cellular transformation

1984 • 132 citations

The p35p36 substrates of protein-tyrosine kinases as inhibitors of phospholipase A2

1986 • 128 citations

Rous sarcoma virus transforming protein, p60src, expressed in E. coli, functions as a protein kinase

1981 • 126 citations

A mutation at the ATP-binding site of pp60v-src abolishes kinase activity, transformation, and tumorigenicity.

1985 • 126 citations

The stimulation of pp60v-src kinase activity by vanadate in intact cells accompanies a new phosphorylation state of the enzyme.

1984 • 121 citations

Modelling the ATP‐binding site of oncogene products, the epidermal growth factor receptor and related proteins

1984 • 121 citations

Restriction of the In Vitro and In Vivo Tyrosine Protein Kinase Activities of pp60^c-src Relative to pp60^v-src

1985 • 119 citations

Mechanism of photoinactivation and re-activation in the bioluminescence system of the ctenophore Mnemiopsis

1984 • 111 citations

Two cellular proteins that immunoprecipitate with the transforming protein of Rous sarcoma virus

1981 • 110 citations

Dissociation of transformation parameters using temperature-conditional mutants of Rous sarcoma virus

1979 • 108 citations

Only membrane-associated RSV src proteins have amino-terminally bound lipid

1983 • 107 citations

Antibodies against synthetic peptides as a tool for functional analysis of the transforming protein pp60src

1983 • 103 citations

Processing of p60v-src to its myristylated membrane-bound form.

1985 • 102 citations

Distinguishable transformation-defective phenotypes among temperature-sensitive mutants of Rous sarcoma virus

1977 • 99 citations

Interaction between the Rous sarcoma virus transforming protein and two cellular phosphoproteins: analysis of the turnover and distribution of this complex.

1983 • 88 citations

N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene.

1985 • 88 citations

Genetic Recombination among Temperature-sensitive Mutants of Rous Sarcoma Virus

1974 • 87 citations

Changes in phosphatidylinositol metabolism correlated to growth state of normal and Rous sarcoma virus-transformed Japanese quail cells.

1977 • 85 citations

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

1982 • 83 citations

Revertants of an ASV-transformed rat cell line have lost the complete provirus or sustained mutations insrc

1981 • 81 citations

Low level of cellular protein phosphorylation by nontransforming overproduced p60c-src.

1985 • 78 citations

Transformation-defective mutants of Rous sarcoma virus with src gene deletions of varying length

1977 • 78 citations

Rous sarcoma virus-induced phosphorylation of a 50,000-molecular weight cellular protein

1982 • 77 citations

Transformation Parameters and pp60^src Localization in Cells Infected with Partial Transformation Mutants of Rous Sarcoma Virus

1983 • 75 citations

Phosphorylation of the transforming protein of Rous sarcoma virus: direct demonstration of phosphorylation of serine 17 and identification of an additional site of tyrosine phosphorylation in p60v-src of Prague Rous sarcoma virus

1986 • 75 citations

Amino Acid Alterations Within a Highly Conserved Region of the Rous Sarcoma Virus src Gene Product pp60^src Inactivate Tyrosine Protein Kinase Activity

1984 • 75 citations

Subcellular Localization of pp60 src in RSV-Transformed Cells

1983 • 73 citations

Identification of Phosphotyrosine-Containing Proteins in Untransformed and Rous Sarcoma Virus-Transformed Chicken Embryo Fibroblasts

1982 • 71 citations

Virus-specific messenger RNAs in permissive cells infected by avian sarcoma virus.

1979 • 70 citations

Increase in the phosphotransferase specific activity of purified Rous sarcoma virus pp60v-src protein after incubation with ATP plus Mg2+.

1983 • 68 citations

Mutation of a termination codon affects src initiation.

1984 • 68 citations

Structurally and Functionally Modified Forms of pp60^v-src in Rous Sarcoma Virus-Transformed Cell Lysates

1984 • 68 citations

Frameshift and intragenic suppressor mutations in a rous sarcoma provirus suggest src encodes two proteins

1983 • 66 citations

Biological properties of "partial" transformation mutants of Rous sarcoma virus and characterization of their pp60src kinase

1981 • 62 citations

Phosphotyrosine-containing proteins and expression of transformation parameters in cells infected with partial transformation mutants of Rous sarcoma virus

1983 • 62 citations

Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus

1982 • 60 citations

Antiserum specific for the carboxy terminus of the transforming protein of Rous sarcoma virus

1982 • 54 citations

Evidence the pp60src, the product of the Rous sarcoma virus src gene, undergoes autophosphorylation

1982 • 54 citations

Restriction of the in vitro and in vivo tyrosine protein kinase activities of pp60c-src relative to pp60v-src.

1985 • 54 citations

Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells.

1985 • 53 citations

Rous sarcoma virus variants that encode src proteins with an altered carboxy terminus are defective for cellular transformation

1985 • 53 citations

A mutation at the major phosphotyrosine in pp60v-src alters oncogenic potential

1984 • 52 citations

Small deletion in src of Rous sarcoma virus modifying transformation phenotypes: identification of 207-nucleotide deletion and its smaller product with protein kinase activity

1983 • 52 citations

Expression of Viral Oncogenes in Differentiating Chick Embryo Neuroretinal Cells Infected with Avian Tumor Viruses

1980 • 51 citations

Association of pp60src and src protein kinase activity with the plasma membrane of nonpermissive and permissive avian sarcoma virus-infected cells

1980 • 51 citations

Cancer cells 2: Oncogenes and viral genes

1985 • 51 citations

Site-Specific Increased Phosphorylation of pp60 ^{v- src} After Treatment of RSV-Transformed Cells with a Tumor Promoter

1985 • 49 citations

Features of the pp60^v-src Carboxyl Terminus That Are Required for Transformation

1986 • 47 citations

Tyrosine phosphorylation of a 50K cellular polypeptide associated with the Rous sarcoma virus transforming protein pp60src.

1982 • 46 citations

Cyclic AMP treatment of Rous sarcoma virus-transformed Chinese hamster ovary cells increases phosphorylation of pp60src and increases pp60src kinase activity.

1983 • 45 citations

The use of Rous sarcoma virus transformation mutants with differing tyrosine kinase activities to study the relationships between vinculin phosphorylation, pp60v-src location and adhesion plaque integrity

1986 • 45 citations

Functional domains of the pp60v-src protein as revealed by analysis of temperature-sensitive Rous sarcoma virus mutants.

1984 • 45 citations

Characterization of the Rous sarcoma virus transforming gene product.

1983 • 43 citations

Transformation by avian sarcoma viruses leads to phosphorylation of multiple cellular proteins on tyrosine residues

1982 • 43 citations

Activation of the cellular src gene by transducing retrovirus.

1986 • 43 citations

Size-Variant pp60^src Proteins of Recovered Avian Sarcoma Viruses Interact with Adhesion Plaques as Peripheral Membrane Proteins: Effects on Cell Transformation

1984 • 40 citations

Increased Phosphorylation of Tyrosine in Vinculin Does Not Occur upon Transformation by Some Avian Sarcoma Viruses

1985 • 39 citations

Comparison of the relative importance of tyrosine-specific vinculin phosphorylation and the loss of surface-associated fibronectin in the morphology of cells transformed by rous sarcoma virus

1986 • 34 citations

Transformation parameters and pp60src localization in cells infected with partial transformation mutants of Rous sarcoma virus.

1983 • 34 citations

Phosphotyrosyl-Protein Phosphatases

1983 • 32 citations

Phosphatidylinositol Kinase Activity in Virus-Transformed and Nontransformed Cells

1985 • 32 citations

Inter- and intramolecular interactions of highly purified Rous sarcoma virus-transforming protein, pp60v-src.

1985 • 31 citations

The Viral Tyrosine Protein Kinases

1986 • 31 citations

Intracellular localization and processing of pp60v-src proteins expressed by two distinct temperature-sensitive mutants of Rous sarcoma virus

1986 • 31 citations

Sites of synthesis of viral proteins in avian sarcoma virus-infected chicken cells

1980 • 31 citations

Regulation of cellular morphology by the Rous sarcoma virus src gene: analysis of fusiform mutants.

1985 • 31 citations

Molecular events leading to fusiform morphological transformation by partial src deletion mutant of rous sarcoma virus

1983 • 31 citations

pp60^c‐src is a substrate for phosphorylation when cells are stimulated to enter cycle

1984 • 30 citations

Specific transforming potential of oncogenes encoding protein-tyrosine kinases.

1985 • 30 citations

Two independent mutations are required for temperature-sensitive cell transformation by a Rous sarcoma virus temperature-sensitive mutant

1985 • 29 citations

Amino acid alterations within a highly conserved region of the Rous sarcoma virus src gene product pp60src inactivate tyrosine protein kinase activity.

1984 • 29 citations

Cytoskeletal organization, vinculin-phosphorylation, and fibronectin expression in transformed fibroblasts with different cell morphologies

1986 • 28 citations

Role of Tyrosine Phosphorylation in Malignant Transformation by Viruses and in Cellular Growth Control

1983 • 27 citations

Phosphatidylinositol kinase activity in virus-transformed and nontransformed cells.

1985 • 25 citations

Localization of temperature-sensitive transformation mutations and back mutations in the Rous sarcoma virus src gene

1986 • 25 citations

Four Rous sarcoma virus mutants which affect transformed cell morphology exhibit altered src gene products

1981 • 25 citations

Structurally and functionally modified forms of pp60v-src in Rous sarcoma virus-transformed cell lysates.

1984 • 25 citations

Lack of Induction of Neuroretinal Cell Proliferation by Rous Sarcoma Virus Variants That Carry the c-src Gene

1985 • 25 citations

From c-src to v-src, or the case of the missing C terminus.

1986 • 23 citations

Mapping of nonconditional and conditional mutants in the src gene of Prague strain Rous sarcoma virus

1982 • 23 citations

Features of the pp60v-src carboxyl terminus that are required for transformation.

1986 • 21 citations

Increased phosphorylation of tyrosine in vinculin does not occur upon transformation by some avian sarcoma viruses.

1985 • 21 citations

Analysis of the pathogenicity of transformation defective partial deletion mutants of avian sarcoma virus: Characterization of recovered viruses which encode novel src specific proteins

1983 • 19 citations

The expression of pp60src and its associated protein kinase activity in cells infected with different transformation-defective temperature-sensitive mutants of rous sarcoma virus

1980 • 19 citations

Characterization of the monomeric and complex-associated forms of the gag-onc fusion proteins of three isolates of feline sarcoma virus: Phosphorylation, kinase activity, acylation, and kinetics of complex formation

1986 • 18 citations

Size-variant pp60src proteins of recovered avian sarcoma viruses interact with adhesion plaques as peripheral membrane proteins: effects on cell transformation.

1984 • 14 citations

Role of the mitogenic property and kinase activity of p60src in tumor formation by Rous sarcoma virus

1984 • 14 citations

Characterization of pp60src phosphorylation in vitro in Rous sarcoma virus-transformed cell membranes.

1985 • 14 citations

Presence of Haemoproteus sp. in House Sparrows in England

1967 • 13 citations

Lack of induction of neuroretinal cell proliferation by Rous sarcoma virus variants that carry the c-src gene.

1985 • 11 citations

Ultraviolet continuum variability of the quasar 3C273

1985 • 9 citations

Transforming mutations in protein—tyrosine kinase genes

1986 • 6 citations

pp60src-Dependent protein phosphorylation in membranes from Rous sarcoma virus-transformed chicken embryo fibroblasts

1985 • 4 citations