Amino acid substitutions sufficient to convert the nontransforming p60c-src protein to a transforming protein.

Fused transcript of abl and bcr genes in chronic myelogenous leukaemia

1985 • 1,650 citations

DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells.

1979 • 1,339 citations

An alteration of the human c-abl protein in K562 leukemia cells unmasks associated tyrosine kinase activity

1984 • 913 citations

Structure and sequence of the cellular gene homologous to the RSV src gene and the mechanism for generating the transforming virus

1983 • 586 citations

Isolation of monoclonal antibodies that recognize the transforming proteins of avian sarcoma viruses

1983 • 518 citations

Polyoma virus transforming protein associates with the product of the c-src cellular gene

1983 • 497 citations

A short sequence in the p60src N terminus is required for p60src myristylation and membrane association and for cell transformation.

1984 • 447 citations

Changes in protein phosphorylation in Rous sarcoma virus-transformed chicken embryo cells.

1981 • 440 citations

Identification of a cellular protein substrate phosphorylated by the avian sarcoma virus-transforming gene product

1980 • 420 citations

Neurones express high levels of a structurally modified, activated form of pp60c-src

1985 • 372 citations

Rous sarcoma virus variants that carry the cellular src gene instead of the viral src gene cannot transform chicken embryo fibroblasts.

1984 • 239 citations

RAPID TRANSFORMATION OF CELLS BY ROUS SARCOMA VIRUS

1969 • 203 citations

Structural and functional domains of the Rous sarcoma virus transforming protein (pp60src).

1981 • 203 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Local mutagenesis of Rous sarcoma virus: The major sites of tyrosine and serine phosphorylation of p60src are dispensable for transformation

1983 • 189 citations

Low Level of Cellular Protein Phosphorylation by Nontransforming Overproduced p60^c-src

1985 • 176 citations

Nucleotide sequence of avian sarcoma virus UR2 and comparison of its transforming gene with other members of the tyrosine protein kinase oncogene family

1985 • 167 citations

Activation of the c-abl oncogene by viral transduction or chromosomal translocation generates altered c-abl proteins with similar in vitro kinase properties.

1985 • 162 citations

Activation of the transforming potential of p60c-src by a single amino acid change.

1986 • 161 citations

DNA sequence of the viral and cellular src gene of chickens. 1. Complete nucleotide sequence of an EcoRI fragment of recovered avian sarcoma virus which codes for gp37 and pp60src

1982 • 152 citations

DNA sequence of the viral and cellular src gene of chickens. II. Comparison of the src genes of two strains of avian sarcoma virus and of the cellular homolog

1982 • 136 citations

Restriction of the In Vitro and In Vivo Tyrosine Protein Kinase Activities of pp60^c-src Relative to pp60^v-src

1985 • 119 citations

N-terminal deletions in Rous sarcoma virus p60src: effects on tyrosine kinase and biological activities and on recombination in tissue culture with the cellular src gene.

1985 • 88 citations

Site-directed mutagenesis of the src gene of Rous sarcoma virus: construction and characterization of a deletion mutant temperature sensitive for transformation

1982 • 83 citations

Analysis of the catalytic domain of phosphotransferase activity of two avian sarcoma virus-transforming proteins.

1984 • 81 citations

Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen.

1985 • 73 citations

Activation of the transformation potential of the cellular fps gene

1985 • 67 citations

Role of p60src kinase activity in the induction of neuroretinal cell proliferation by rous sarcoma virus

1982 • 60 citations

DNA sequence of the Bryan high-titer strain of Rous sarcoma virus: extent of env deletion and possible genealogical relationship with other viral strains

1984 • 60 citations

Comparison Between the Viral Transforming Gene (src) of Recovered Avian Sarcoma Virus and Its Cellular Homolog

1981 • 52 citations

Polymerase-defective mutant of the Bryan high-titer strain ofRous sarcoma virus

1986 • 25 citations