Neoplastic Transformation Induced by an Activated Lymphocyte-Specific Protein Tyrosine Kinase (pp56^lck)

A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding

1976 • 200,127 citations

DNA sequencing with chain-terminating inhibitors

1977 • 69,181 citations

Peptide mapping by limited proteolysis in sodium dodecyl sulfate and analysis by gel electrophoresis.

1977 • 5,640 citations

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine

1980 • 2,387 citations

Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus

1983 • 1,857 citations

Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells

1977 • 1,411 citations

[32] Oligonucleotide-directed mutagenesis of DNA fragments cloned into M13 vectors

1983 • 1,093 citations

Nucleotide sequence of rous sarcoma virus

1983 • 901 citations

Plasmid-encoded hygromycin B resistance: the sequence of hygromycin B phosphotransferase gene and its expression in Escherichia coli and Saccharomyces cerevisiae

1983 • 810 citations

Activation and suppression of pp60c-src transforming ability by mutation of its primary sites of tyrosine phosphorylation

1987 • 648 citations

Viral oncogenes

1985 • 605 citations

Transcriptional regulation of the mouse metallothionein-I gene by heavy metals.

1981 • 601 citations

Tyr ⁵²⁷ Is Phosphorylated in pp60 ^{c- src} : Implications for Regulation

1986 • 567 citations

Tyrosine phosphorylation regulates the biochemical and biological properties of pp60c-src

1987 • 567 citations

Evidence that the phosphorylation of tyrosine is essential for cellular transformation by Rous sarcoma virus

1980 • 560 citations

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA

1985 • 550 citations

Cell lineage ablation in transgenic mice by cell-specific expression of a toxin gene

1987 • 479 citations

Activation of the pp60c-src kinase by middle T antigen binding or by dephosphorylation.

1985 • 439 citations

A practical approach for quantitating specific mRNAs by solution hybridization

1983 • 427 citations

Cell transformation by pp60c-src mutated in the carboxy-terminal regulatory domain

1987 • 410 citations

Characterization of Rous sarcoma virus src gene products synthesized in vitro

1978 • 352 citations

Avian sarcoma virus Y73 genome sequence and structural similarity of its transforming gene product to that of Rous sarcoma virus

1982 • 294 citations

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion

1986 • 290 citations

A tail of two src's: Mutatis mutandis

1987 • 278 citations

Gene Product of v- fgr onc : Hybrid Protein Containing a Portion of Actin and a Tyrosine-Specific Protein Kinase

1984 • 240 citations

yes-related protooncogene, syn, belongs to the protein-tyrosine kinase family.

1986 • 219 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus.

1987 • 179 citations

Association of the polyomavirus middle-T antigen with c-yes protein

1987 • 172 citations

Association of p60src with Triton X-100-resistant cellular structure correlates with morphological transformation.

1987 • 163 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases.

1987 • 139 citations

New Method for Detecting Cellular Transforming Genes

1982 • 131 citations

Enzymatically inactive p60c-src mutant with altered ATP-binding site is fully phosphorylated in its carboxy-terminal regulatory region

1987 • 117 citations

Lethal effect of the abelson murine leukemia virus transforming gene product

1981 • 101 citations

Localization of a lymphocyte-specific protein tyrosine kinase gene (lck) at a site of frequent chromosomal abnormalities in human lymphomas.

1986 • 96 citations

A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity.

1983 • 94 citations

High level of tyrosine protein kinase in a murine lymphoma cell line induced by Moloney leukemia virus.

1982 • 45 citations

Sites of in vivo phosphorylation of the T cell tyrosine protein kinase in LSTRA cells and their alteration by tumor-promoting phorbol esters.

1987 • 39 citations

PHOSPHORYLATION OF TYROSINE: A MECHANISM OF TRANSFORMATION SHARED BY A NUMBER OF OTHERWISE UNRELATED RNA TUMOR VIRUSES

1980 • 13 citations