Signal Transduction Mechanisms for Adenosine

Inositol trisphosphate, a novel second messenger in cellular signal transduction

1984 • 6,088 citations

Three types of neuronal calcium channel with different calcium agonist sensitivity

1985 • 2,212 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

Advances in Cyclic Nucleotide Research.

1980 • 1,465 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Isolation of two proteins with high affinity for guanine nucleotides from membranes of bovine brain.

1984 • 1,300 citations

The βγ subunits of GTP-binding proteins activate the muscarinic K+ channel in heart

1987 • 1,186 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Biochemical Properties of Hormone-Sensitive Adenylate Cyclase

1980 • 1,016 citations

The GTP-binding protein, Go9 regulates neuronal calcium channels

1987 • 910 citations

Characterization of the A2 adenosine receptor labeled by [3H]NECA in rat striatal membranes.

1986 • 821 citations

Regulation of transmembrane signaling by receptor phosphorylation

1987 • 678 citations

Acetylcholine Receptor: An Allosteric Protein

1984 • 620 citations

A rapid filtration assay for soluble receptors using polyethylenimine-treated filters

1983 • 578 citations

Two distinct adenosine-sensitive sites on adenylate cyclase.

1977 • 574 citations

On the mechanism of activation of muscarinic K+ channels by adenosine in isolated atrial cells: involvement of GTP-binding proteins

1986 • 510 citations

Specific uncoupling by islet-activating protein, pertussis toxin, of negative signal transduction via alpha-adrenergic, cholinergic, and opiate receptors in neuroblastoma x glioma hybrid cells.

1983 • 493 citations

Topics and Perspectives in Adenosine Research

1987 • 459 citations

Direct Activation of Mammalian Atrial Muscarinic Potassium Channels by GTP Regulatory Protein G _k

1987 • 441 citations

On the mechanism of ?-adrenergic regulation of the Ca channel in the guinea-pig heart

1985 • 396 citations

Binding of the A1-selective adenosine antagonist 8-cyclopentyl-1,3-dipropylxanthine to rat brain membranes

1987 • 376 citations

Advances in Cyclic Nucleotide and Protein Phosphorylation Research

1975 • 373 citations

Calcium channel currents and their inhibition by (‐)‐baclofen in rat sensory neurones: modulation by guanine nucleotides.

1987 • 342 citations

Modification by islet-activating protein of receptor-mediated regulation of cyclic AMP accumulation in isolated rat heart cells.

1981 • 326 citations

The α Subunit of the GTP Binding Protein G _k Opens Atrial Potassium Channels

1987 • 317 citations

Size determination of enzymes by radiation inactivation

1979 • 316 citations

Reconstitution of resolved muscarinic cholinergic receptors with purified GTP-binding proteins.

1985 • 314 citations

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1980 • 296 citations

Adenosine receptors and calcium: Basis for proposing a third (A3) adenosine receptor

1986 • 284 citations

Purification of the catalyst of adenylate cyclase.

1986 • 259 citations

Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning.

1987 • 185 citations

Advances in cyclic nucleotide research

1980 • 184 citations

Receptor biochemistry and methodology

1985 • 181 citations

The fat cell adenylate cyclase system. Characterization and manipulation of its bimodal regulation by GTP.

1979 • 171 citations

Guanine nucleotide and cation regulation of the binding of [3H]cyclohexyladenosine and [3H]diethylphenylxanthine to adenosine A1 receptors in brain membranes.

1982 • 169 citations

Bimodal regulation of adenylate cyclase

1982 • 161 citations

Inhibitory and stimulatory G proteins of adenylate cyclase: cDNA and amino acid sequences of the alpha chains.

1986 • 159 citations

Adenosine and Adenosine Receptors

1990 • 142 citations

Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s).

1982 • 137 citations

Purines : pharmacology and physiological roles

1985 • 134 citations

Adenosine receptors and the regulation of adenylate cyclase.

1981 • 133 citations

Solubilization of human platelet alpha-adrenergic receptors: evidence that agonist occupancy of the receptor stabilizes receptor--effector interactions.

1981 • 124 citations

Adenosine receptors: structure, function and regulation

1986 • 124 citations

Receptor Biochemistry ahd Methodology

1984 • 122 citations

Agonist and antagonist affinities for inhibitory adenosine receptors are reciprocally affected by 5'-guanylylimidodiphosphate or N-ethylmaleimide.

1983 • 119 citations

A second form of the beta subunit of signal-transducing G proteins.

1987 • 118 citations

The A1 adenosine receptor. Solubilization and characterization of a guanine nucleotide-sensitive form of the receptor.

1985 • 118 citations

Adenosine inhibition of catecholamine-induced increase in force of contraction in guinea-pig atrial and ventricular heart preparations. Evidence against a cyclic AMP- and cyclic GMP-dependent effect.

1984 • 109 citations

Muscarinic cholinergic receptor structure. Receptor size, membrane orientation, and absence of major phylogenetic structural diversity.

1983 • 101 citations

PD 115,199: An antagonist ligand for adenosine A2 receptors

1987 • 96 citations

Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors.

1983 • 90 citations

Solubilized Adenosine Receptors in the Brain: Regulation of Guanine Nucleotides

1982 • 89 citations

Adenosine Receptor Subtypes: Binding Studies

1987 • 85 citations

Structure-activity relationships for N6-substituted adenosines at a brain A1-adenosine receptor with a comparison to an A2-adenosine receptor regulating coronary blood flow

1986 • 81 citations

Identification of the A2 adenosine receptor binding subunit by photoaffinity crosslinking.

1989 • 81 citations

Regulation by glucagon and divalent cations of inhibition of hepatic adenylate cyclase by adenosine.

1977 • 80 citations

Calcium as intracellular messenger: sensitivity modulation, C-kinase pathway, and sustained cellular response.

1984 • 79 citations

Agonist binding promotes a guanine nucleotide reversible increase in the apparent size of the bovine anterior pituitary dopamine receptors.

1983 • 78 citations

Effects of N‐ethylmaleimide and forskolin on noradrenaline release from rat hippocampal slices. Evidence that prejunctional adenosine and a‐receptors are linked to A/‐proteins but not to adenylate cyclase

1987 • 78 citations

Dopamine, acting through D-2 receptors, inhibits rat striatal adenylate cyclase by a GTP-dependent process.

1986 • 78 citations

Role of intracellular Mg2+ in the activation of muscarinic K+ channel in cardiac atrial cell membrane

1986 • 77 citations

Studies on the adenosine‐receptor mediating the augmentation of histamine‐induced inositol phospholipid hydrolysis in guinea‐pig cerebral cortex

1987 • 67 citations

Adenosine A1 receptors in mammalian brain: Species differences in their interactions with agonists and antagonists

1986 • 66 citations

Definition of subclasses of adenosine receptors associated with adenylate cyclase: interaction of adenosine analogs with inhibitory A₁ receptors and stimulatory A₂ receptors

1987 • 64 citations

Studies on the receptor mediating cyclic AMP‐independent enhancement by adenosine of IgE‐dependent mediator release from rat mast cells

1986 • 56 citations

Different sedimentation properties of agonist- and antagonist-labelled platelet alpha2 adrenergic receptors

1981 • 51 citations

Characterization of the Solubilized A₁ Adenosine Receptor from Rat Brain Membranes

1986 • 48 citations

A temperature gradient method for lipid phase diagram construction using time-resolved x-ray diffraction

1987 • 47 citations

Inhibition and activation of fat cell adenylate cyclase by GTP is mediated by structures of different size

1980 • 44 citations

Calmodulin plays a dominant role in determining neurotransmitter regulation of neuronal adenylate cyclase

1988 • 44 citations

Guanine nucleotide and cation regulation of radioligand binding to R i adenosine receptors of rat fat cells

1984 • 44 citations

Adenosine potentiates immunological histamine release from rat mast cells by a novel cyclic AMP‐independent cell‐surface action

1985 • 40 citations

Ionic Channels and Adenosine in Isolated Heart Cells

1987 • 40 citations

Adenosine receptor agonists inhibit inositol phosphate accumulation in rat striatal slices

1987 • 33 citations

Effects of N‐ethylmaleimide and forskolin on glutamate release from rat hippocampal slices. Evidence that prejunctional adenosine receptors are linked to N‐proteins, but not to adenylate cyclase

1986 • 33 citations

Magnesium ion exerts a central role in the regulation of inhibitory adenosine receptors

1985 • 30 citations

Evaluation of the effects of adenosine on hepatic and adipocyte adenylate cyclase under conditions where adenosine is not generated endogenously.

1979 • 28 citations

Solubilization and partial characterization of adenosine binding sites from rat brainstem

1983 • 27 citations

Independent mechanisms of adenosine activation and inhibition of the turkey erythrocyte adenylate cyclase system.

1980 • 26 citations

Target size of the adenosine Ri receptor

1986 • 25 citations

Role of Calmodulin in the Effect of Guanyl Nucleotides on Rat Hippocampal Adenylate Cyclase: Involvement of Adenosine and Opiates

1983 • 23 citations

Calmodulin may play a pivotal role in neurotransmitter-mediated inhibition and stimulation of rat cerebellar adenylate cyclase.

1987 • 23 citations

Hydrodynamic properties of adenosine Ri receptors solubilized from rat cerebral-cortical membranes

1987 • 22 citations

The Negative Chronotropic Effect of Adenosine in Sinus Node Cells

1987 • 21 citations

Interaction of the Inhibitory GTP Regulatory Component with Soluble Cerebral Cortical Adenylate Cyclase

1986 • 19 citations

Inhibition of Calcium Currents by an Adenosine Analogue 2-Chloroadenosine

1987 • 18 citations

Mechanisms Underlying Physiological Responses to Adenosine in the Central Nervous System

1987 • 18 citations

Adenosine A1 receptors inhibit both adenylate cyclase activity and TRH-activated Ca2+ channels by a pertussis toxin-sensitive mechanism in GH3 cells

1989 • 18 citations

Biochemical and Autoradiographic Approaches to the Characterization of Adenosine Receptors in Brain

1987 • 15 citations

Agonist and Antagonist Radioligands and Photoaffinity Labels for the Adenosine A1 Receptor

1987 • 13 citations

Properties required of a functional Ni, the GTP regulatory complex that mediates the inhibitory actions of neurotransmitters on adenylate cyclase.

1985 • 9 citations

Collagen glucosyl- and galactosyltransferases of cultured human fetal lung fibroblasts

1981 • 9 citations

Biochemical characterization of the adrenergic receptors: affinity labeling, purification, and reconstitution studies.

1985 • 8 citations

Magnesium Ions Exert a Central Role in Integrating Adenosine Receptor Occupancy with the Inhibition of Adenylate Cyclase

1985 • 5 citations

Structural Studies on Adenosine Ri Receptors from Rat Cerebral Cortex

1987 • 5 citations

A Central Role for Magnesium in the Regulation of Inhibitory Adenosine Receptors

1984 • 5 citations

Potency of N6-modified N-alkyl adenosine-5?-uronamides at presynaptic adenosine receptors in guinea-pig ileum

1987 • 4 citations

Adenosine and transmitter release

1986 • 4 citations