Agonist and antagonist affinities for inhibitory adenosine receptors are reciprocally affected by 5'-guanylylimidodiphosphate or N-ethylmaleimide.

Relationship between the inhibition constant (KI) and the concentration of inhibitor which causes 50 per cent inhibition (I50) of an enzymatic reaction

1973 • 12,522 citations

LIGAND: A versatile computerized approach for characterization of ligand-binding systems

1980 • 8,534 citations

A highly sensitive adenylate cyclase assay

1974 • 4,213 citations

The role of hormone receptors and GTP-regulatory proteins in membrane transduction

1980 • 1,750 citations

A ternary complex model explains the agonist-specific binding properties of the adenylate cyclase-coupled beta-adrenergic receptor.

1980 • 1,579 citations

ADENOSINE REGULATES VIA TWO DIFFERENT TYPES OF RECEPTORS, THE ACCUMULATION OF CYCLIC AMP IN CULTURED BRAIN CELLS

1979 • 1,370 citations

Subclasses of external adenosine receptors.

1980 • 1,087 citations

Neurotransmitter receptor binding

1978 • 822 citations

Direct modification of the membrane adenylate cyclase system by islet-activating protein due to ADP-ribosylation of a membrane protein.

1982 • 808 citations

The binding of agonists to brain muscarinic receptors.

1978 • 656 citations

Adenosine receptors in brain membranes: binding of N6-cyclohexyl[3H]adenosine and 1,3-diethyl-8-[3H]phenylxanthine.

1980 • 554 citations

Lectures on Biostatistics.

1972 • 551 citations

A quantitative analysis of beta-adrenergic receptor interactions: resolution of high and low affinity states of the receptor by computer modeling of ligand binding data.

1980 • 545 citations

Lectures on biostatistics

1971 • 419 citations

Activation and attenuation of adenylate cyclase. The role of GTP-binding proteins as macromolecular messengers in receptor–cyclase coupling

1981 • 322 citations

An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor.

1976 • 318 citations

Characterization of adenosine receptors in rat brain by (?)[3H]N6-phenylisopropyladenosine

1980 • 296 citations

Interaction of ligands with the opiate receptors of brain membranes: Regulation by ions and nucleotides

1978 • 216 citations

Guanine nucleotide and cation regulation of the binding of [3H]cyclohexyladenosine and [3H]diethylphenylxanthine to adenosine A1 receptors in brain membranes.

1982 • 169 citations

Bimodal regulation of adenylate cyclase

1982 • 161 citations

Biochemical characterization of putative central purinergic receptors by using 2-chloro[3H]adenosine, a stable analog of adenosine.

1980 • 155 citations

An A1-adenosine receptor, characterized by [3H]cyclohexyladenosine binding, mediates the depression of evoked potentials in a rat hippocampal slice preparation

1982 • 140 citations

Differential modification of the interaction of cardiac muscarinic cholinergic and beta-adrenergic receptors with a guanine nucleotide binding component(s).

1982 • 137 citations

Reciprocal modulation of agonist and antagonist binding to muscarinic cholinergic receptor by guanine nucleotide.

1982 • 132 citations

Adenosine receptors in fat cells. Identification by (-)-N6-[3H]phenylisopropyladenosine binding.

1981 • 118 citations

The agonist-specific effect of magnesium ion on binding by beta-adrenergic receptors in S49 lymphoma cells. Interaction of GTP and magnesium in adenylate cyclase activation.

1978 • 111 citations

Interactions of Divalent Cations and Guanine Nucleotides at α₂‐Noradrenergic Receptor Binding Sites in Bovine Brain Mechanisms

1980 • 99 citations

Characterization of adenosine receptors in brain using N6 cyclohexyl [3H]adenosine

1982 • 91 citations

Two populations of binding sites for muscarinic antagonists in the rat heart

1981 • 86 citations

Multiple reactive sulfhydryl groups modulate the function of adenylate cyclase coupled beta-adrenergic receptors.

1979 • 83 citations

Requirement for sulfhydryl groups in the differential effects of magnesium ion and GTP on agonist binding of muscarinic cholinergic receptor sites in rat atrial membrane fraction

1980 • 77 citations

Regulation of Adenosine‐Sensitive Adenylate Cyclase from Rat Brain Striatum

1980 • 44 citations

GUANINE NUCLEOTIDES REGULATE BOTH DOPAMINERGIC AGONIST AND ANTAGONIST BINDING IN PORCINE ANTERIOR PITUITARY

1982 • 42 citations

Dopamine receptor of the porcine anterior pituitary gland. Effects of N-ethylmaleimide and heat on ligand binding mimic the effects of guanine nucleotides.

1982 • 38 citations

Magnesium reduces affinities of antagonists at rat cortex α2-adrenergic receptors labeled with 3H-clonidine: Evidence for heterogeneity of α2-receptor conformations with respect to antagonists

1982 • 37 citations

Regulation of antagonist binding to cardiac muscarinic receptors

1982 • 28 citations

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