Transcriptional regulatory cascades controlling plasma cell differentiation

XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

2001 • 3,799 citations

Class Switch Recombination and Hypermutation Require Activation-Induced Cytidine Deaminase (AID), a Potential RNA Editing Enzyme

2000 • 3,323 citations

IRE1 couples endoplasmic reticulum load to secretory capacity by processing the XBP-1 mRNA

2002 • 2,702 citations

ER Stress Regulation of ATF6 Localization by Dissociation of BiP/GRP78 Binding and Unmasking of Golgi Localization Signals

2002 • 1,368 citations

Plasma cell differentiation requires the transcription factor XBP-1

2001 • 1,256 citations

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

1998 • 1,216 citations

Commitment to the B-lymphoid lineage depends on the transcription factor Pax5

1999 • 1,139 citations

BLyS: Member of the Tumor Necrosis Factor Family and B Lymphocyte Stimulator

1999 • 1,123 citations

General Conclusions: Teleonomic Mechanisms in Cellular Metabolism, Growth, and Differentiation

1961 • 1,043 citations

Hypermutation of multiple proto-oncogenes in B-cell diffuse large-cell lymphomas

2001 • 1,020 citations

Blimp-1 Orchestrates Plasma Cell Differentiation by Extinguishing the Mature B Cell Gene Expression Program

2002 • 1,000 citations

Control of Inflammation, Cytokine Expression, and Germinal Center Formation by BCL-6

1997 • 921 citations

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to thecis-Acting Element Responsible for the Mammalian Unfolded Protein Response

2000 • 921 citations

BCL-6 Represses Genes that Function in Lymphocyte Differentiation, Inflammation, and Cell Cycle Control

2000 • 862 citations

The BCL-6 proto-oncogene controls germinal-centre formation and Th2-type inflammation

1997 • 815 citations

Blimp-1, a novel zinc finger-containing protein that can drive the maturation of B lymphocytes into immunoglobulin-secreting cells

1994 • 752 citations

Origins and Functions of B-1 Cells with Notes on the Role of CD5

2002 • 752 citations

B lymphocyte-specific, Cre-mediated mutagenesis in mice

1997 • 696 citations

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

2001 • 693 citations

A Coordinated Change in Chemokine Responsiveness Guides Plasma Cell Movements

2001 • 620 citations

Generation of Memory B Cells and Plasma Cells in Vitro

1995 • 585 citations

BCL-6 protein is expressed in germinal-center B cells

1995 • 582 citations

Requirement for the Transcription Factor LSIRF/IRF4 for Mature B and T Lymphocyte Function

1997 • 581 citations

BCL-6 mutations in normal germinal center B cells: Evidence of somatic hypermutation acting outside Ig loci

1998 • 539 citations

An essential role in liver development for transcription factor XBP-1

2000 • 503 citations

A monoclonal antibody (MUM1p) detects expression of the MUM1/IRF4 protein in a subset of germinal center B cells, plasma cells, and activated T cells

2000 • 478 citations

BCoR, a novel corepressor involved in BCL-6 repression

2000 • 464 citations

The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response

1997 • 437 citations

Blimp-1-Dependent Repression of Pax-5 Is Required for Differentiation of B Cells to Immunoglobulin M-Secreting Plasma Cells

2002 • 427 citations

T-Independent Immune Response: New Aspects of B Cell Biology

2000 • 413 citations

Repression of c- myc Transcription by Blimp-1, an Inducer of Terminal B Cell Differentiation

1997 • 412 citations

Essential functions of Pax5 (BSAP) in pro-B cell development: difference between fetal and adult B lymphopoiesis and reduced V-to-DJ recombination at the IgH locus.

1997 • 411 citations

NFATc1 and NFATc2 Together Control Both T and B Cell Activation and Differentiation

2001 • 397 citations

Acetylation inactivates the transcriptional repressor BCL6

2002 • 383 citations

B‐cell subsets and the mature ­preimmune repertoire. Marginal zone and B1 B cells as part of a “natural immune memory”

2000 • 380 citations

Regulatory Mechanisms that Determine the Development and Function of Plasma Cells

2003 • 364 citations

Identification and characterization of a novel repressor of beta-interferon gene expression.

1991 • 351 citations

Corepressor SMRT binds the BTB/POZ repressing domain of the LAZ3/BCL6 oncoprotein

1997 • 343 citations

Commitment of B Lymphocytes to a Plasma Cell Fate Is Associated with Blimp-1 Expression In Vivo

2000 • 337 citations

Transcriptional Repression by Blimp-1 (PRDI-BF1) Involves Recruitment of Histone Deacetylase

2000 • 328 citations

The promoter of the CD19 gene is a target for the B-cell-specific transcription factor BSAP.

1992 • 325 citations

Interferon Regulatory Factor 4 (IRF4) Interacts with NFATc2 to Modulate Interleukin 4 Gene Expression

2002 • 318 citations

Signatures of the Immune Response

2001 • 315 citations

Identification of BSAP (Pax-5) target genes in early B-cell development by loss- and gain-of-function experiments

1998 • 314 citations

Cutting Edge: BLyS Enables Survival of Transitional and Mature B Cells Through Distinct Mediators

2002 • 309 citations

Plasma cells: finding new light at the end of B cell development

2001 • 305 citations

Activation of an Unfolded Protein Response during Differentiation of Antibody-secreting B Cells

2002 • 297 citations

The Role of Bone Marrow-Derived Stromal Cells in the Maintenance of Plasma Cell Longevity

2002 • 290 citations

Role of BCR affinity in T cell–dependent antibody responses in vivo

2002 • 288 citations

Antigen receptor signaling induces MAP kinase-mediated phosphorylation and degradation of the BCL-6 transcription factor

1998 • 287 citations

A New Member of the Leucine Zipper Class of Proteins that Binds to the HLA DRα Promoter

1990 • 286 citations

Reversion of B Cell Commitment upon Loss of Pax5 Expression

2002 • 285 citations

The T cell-B cell interaction via OX40-OX40L is necessary for the T cell-dependent humoral immune response.

1996 • 284 citations

BCL-6 expression during B-cell activation

1996 • 262 citations

PRDI-BF1/Blimp-1 repression is mediated by corepressors of the Groucho family of proteins

1999 • 248 citations

Pax5/BSAP Maintains the Identity of B Cells in Late B Lymphopoiesis

2001 • 246 citations

Pax5 Promotes B Lymphopoiesis and Blocks T Cell Development by Repressing Notch1

2002 • 239 citations

Maturation of Marginal Zone and Follicular B Cells Requires B Cell Activating Factor of the Tumor Necrosis Factor Family and Is Independent of B Cell Maturation Antigen

2001 • 238 citations

The LAZ3(BCL-6) oncoprotein recruits a SMRT/mSIN3A/histone deacetylase containing complex to mediate transcriptional repression

1998 • 229 citations

Identification of a receptor for BLyS demonstrates a crucial role in humoral immunity

2000 • 229 citations

bcl-2 Transgene Expression Inhibits Apoptosis in the Germinal Center and Reveals Differences in the Selection of Memory B Cells and Bone Marrow Antibody-Forming Cells

2000 • 220 citations

Suppression of Signal Transducer and Activator of Transcription 3–Dependent B Lymphocyte Terminal Differentiation by Bcl-6

2000 • 219 citations

BLIMP-1 mediates extinction of major histocompatibility class II transactivator expression in plasma cells

2000 • 213 citations

A survival pathway forCaenorhabditis eleganswith a blocked unfolded protein response

2002 • 200 citations

Repression of AP-1 Function: A Mechanism for the Regulation of Blimp-1 Expression and B Lymphocyte Differentiation by the B Cell Lymphoma-6 Protooncogene

2002 • 191 citations

Transcription factor B cell lineage-specific activator protein regulates the gene for human X-box binding protein 1.

1996 • 189 citations

A molecular compendium of genes expressed in multiple myeloma

2002 • 186 citations

Very Low Affinity B Cells Form Germinal Centers, Become Memory B Cells, and Participate in Secondary Immune Responses When Higher Affinity Competition Is Reduced

2002 • 181 citations

Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis

1995 • 173 citations

Transcriptional control of B-cell development

2002 • 161 citations

Short-lived and Long-lived Bone Marrow Plasma Cells Are Derived from a Novel Precursor Population

2002 • 155 citations

IL-10 interrupts memory B cell expansion in the germinal center by inducing differentiation into plasma cells

1998 • 155 citations

NF-HB (BSAP) is a repressor of the murine immunoglobulin heavy-chain 3' alpha enhancer at early stages of B-cell differentiation.

1993 • 151 citations

Germinal center reaction

2001 • 140 citations

The B cell-specific transcription factor BSAP regulates B cell proliferation.

1994 • 140 citations

The dynamic expression pattern of B lymphocyte induced maturation protein-1 (Blimp-1) during mouse embryonic development

2002 • 133 citations

Differentiation of early plasma cells on bone marrow stromal cells requires interleukin-6 for escaping from apoptosis

1995 • 131 citations

Antigen-dependent B-cell development

2002 • 130 citations

Regulation of CD27 expression in the course of germinal center B cell differentiation: the pivotal role of IL-10

2000 • 129 citations

An Interleukin-2 Signal Relieves BSAP (Pax5)-Mediated Repression of the Immunoglobulin J Chain Gene

1996 • 125 citations

Human X-box-binding protein 1 is required for the transcription of a subset of human class II major histocompatibility genes and forms a heterodimer with c-fos.

1991 • 125 citations

Only two of the five zinc fingers of the eukaryotic transcriptional repressor PRDI-BF1 are required for sequence-specific DNA binding.

1992 • 119 citations

Negative autoregulation of BCL-6 is bypassed by genetic alterations in diffuse large B cell lymphomas

2002 • 115 citations

Overexpression of B cell-specific activator protein (BSAP/Pax-5) in a late B cell is sufficient to suppress differentiation to an Ig high producer cell with plasma cell phenotype.

1997 • 113 citations

CDK Inhibitor p18INK4c Is Required for the Generation of Functional Plasma Cells

2002 • 106 citations

Repression of c-mycIs Necessary but Not Sufficient for Terminal Differentiation of B Lymphocytes In Vitro

2000 • 100 citations

Mechanism of BLyS action in B cell immunity

2002 • 89 citations

Blimp-1 overcomes the block in IgM secretion in lipopolysaccharide / anti-μ F(ab′)2-co-stimulated B lymphocytes

1996 • 86 citations

A1 expression is stimulated by CD40 in B cells and rescues WEHI 231 cells from anti-IgM-induced cell death

1999 • 82 citations

The Distinct Roles of T Cell-Derived Cytokines and a Novel Follicular Dendritic Cell-Signaling Molecule 8D6 in Germinal Center-B Cell Differentiation

2001 • 67 citations

Lymphocyte Development and Selection in Germinal Centers

1998 • 62 citations

Identification of c-myc promoter-binding protein and X-box binding protein 1 as interleukin-6 target genes in human multiple myeloma cells.

1999 • 61 citations

Identification of negative regulatory regions within the first exon and intron of the BCL6 gene

2000 • 53 citations

Involvement of BCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma.

1998 • 53 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching.

2001 • 52 citations

Reversal of Blimp-1-mediated apoptosis by A1, a member of the Bcl-2 family

1999 • 46 citations

Involvement ofBCL6 in chromosomal aberrations affecting band 3q27 in B-cell non-Hodgkin lymphoma

1998 • 46 citations

Blimp-1 over-expression abrogates IL-4- and CD40-mediated suppression of terminal B cell differentiation but arrests isotype switching

2001 • 41 citations

Deregulation ofBCL6 in non-Hodgkin lymphoma by insertion ofIGH sequences in complex translocations involving band 3q27

1998 • 29 citations

Key differentiation steps in normal B cells and in myeloma cells.

1997 • 27 citations

Unique Function for Carboxyl-Terminal Domain of Oct-2 in Ig-Secreting Cells

2001 • 10 citations

Analysis of hypermutation of the 5' noncoding region in the BCL-6 gene.

2001 • 2 citations

Analysis of hypermutation of the 5’ noncoding region in the BCL-6 gene

2001 • 1 citations