Polypyrimidine Tract-Binding Protein Positively Regulates Inclusion of an Alternative 3′-Terminal Exon

Alternative RNA processing in calcitonin gene expression generates mRNAs encoding different polypeptide products

1982 • 2,114 citations

Exon Recognition in Vertebrate Splicing

1995 • 1,067 citations

Mechanism and regulation of mRNA polyadenylation

1997 • 762 citations

THE STRUCTURE AND FUNCTION OF PROTEINS INVOLVED IN MAMMALIAN PRE-mRNA SPLICING

1996 • 687 citations

The consensus sequence YGTGTTYY located downstream from the AATAAA signal is required for efficient formation of mRNA 3′ termini

1985 • 652 citations

Distinct Binding Specificities and Functions of Higher Eukaryotic Polypyrimidine Tract-Binding Proteins

1995 • 537 citations

Alternative poly(A) site selection in complex transcription units: means to an end?

1997 • 508 citations

Identification, purification, and biochemical characterization of U2 small nuclear ribonucleoprotein auxiliary factor.

1989 • 375 citations

Identification and purification of a 62,000-dalton protein that binds specifically to the polypyrimidine tract of introns.

1989 • 349 citations

Characterization and molecular cloning of polypyrimidine tract-binding protein: a component of a complex necessary for pre-mRNA splicing.

1991 • 338 citations

A splicing enhancer complex controls alternative splicing of doublesex pre-mRNA

1993 • 332 citations

hnRNP 1, the polyprimidine tract-binding protein: distinct nuclear localization and association with hnRNAs

1992 • 299 citations

The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing.

1996 • 286 citations

Initial splice-site recognition and pairing during pre-mRNA splicing

1996 • 281 citations

Interaction of U2AF ⁶⁵ RS Region with Pre-mRNA of Branch Point and Promotion Base Pairing with U2 snRNA

1996 • 279 citations

The splicing factor SRp20 modifies splicing of its own mRNA and ASF/SF2 antagonizes this regulation

1997 • 264 citations

Characterization of cDNAs encoding the polypyrimidine tract-binding protein.

1991 • 257 citations

Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution.

1991 • 255 citations

A sequence downstream of AAUAAA is required for rabbit β-globin mRNA 3′-end formation

1984 • 251 citations

Alternative RNA Processing: Determining Neuronal Phenotype

1984 • 238 citations

Mutation of PTB binding sites causes misregulation of alternative 3' splice site selection in vivo.

1997 • 233 citations

Assembly of specific SR protein complexes on distinct regulatory elements of the Drosophila doublesex splicing enhancer.

1996 • 228 citations

The Polypyrimidine Tract Binding Protein Binds Upstream of Neural Cell-Specific c-src Exon N1 To Repress the Splicing of the Intron Downstream

1997 • 214 citations

A neuron-specific splicing switch mediated by an array of pre-mRNA repressor sites: evidence of a regulatory role for the polypyrimidine tract binding protein and a brain-specific PTB counterpart.

1997 • 213 citations

Post-transcriptional regulation: The dawn of PTB

1997 • 202 citations

Positive Control of Pre-mRNA Splicing in Vitro

1992 • 199 citations

Finding splice sites within a wilderness of RNA.

1995 • 188 citations

The biochemistry of polyadenylation

1996 • 186 citations

Regulation of Alternative Polyadenylation by U1 snRNPs and SRp20

1998 • 186 citations

Regulation of doublesex pre-mRNA processing occurs by 3'-splice site activation.

1991 • 184 citations

Sequences capable of restoring poly(A) site function define two distinct downstream elements.

1986 • 175 citations

Regulation of alternative 3' splice site selection by constitutive splicing factors.

1995 • 170 citations

Multiple RRMs Contribute to RNA Binding Specificity and Affinity for Polypyrimidine Tract Binding Protein

1997 • 168 citations

Interaction between the U1 snRNP-A protein and the 160-kD subunit of cleavage-polyadenylation specificity factor increases polyadenylation efficiency in vitro.

1996 • 167 citations

Polypyrimidine tract binding protein interacts with sequences involved in alternative splicing of beta-tropomyosin pre-mRNA.

1992 • 157 citations

Synergistic interactions between two distinct elements of a regulated splicing enhancer.

1995 • 156 citations

The upstream sequence element of the C2 complement poly(A) signal activates mRNA 3′ end formation by two distinct mechanisms

1998 • 156 citations

An intron enhancer recognized by splicing factors activates polyadenylation.

1996 • 153 citations

Alpha-tropomyosin mutually exclusive exon selection: competition between branchpoint/polypyrimidine tracts determines default exon choice.

1991 • 146 citations

Direct interaction of the U1 snRNP-A protein with the upstream efficiency element of the SV40 late polyadenylation signal.

1994 • 146 citations

Biochemistry and regulation of pre-mRNA splicing

1996 • 136 citations

The human immunodeficiency virus type 1 polyadenylylation signal: a 3' long terminal repeat element upstream of the AAUAAA necessary for efficient polyadenylylation.

1991 • 136 citations

A splicing enhancer exhibits both constitutive and regulated activities.

1994 • 136 citations

ASESORÍAS INNOVADORAS EN RECURSOS HUMANOS PARA LAS PYMES MEDIANTE EL USO DE LA RED DE INTERNET

1969 • 136 citations

Intrinsic U2AF binding is modulated by exon enhancer signals in parallel with changes in splicing activity.

1995 • 133 citations

CPSF recognition of an HIV-1 mRNA 3'-processing enhancer: multiple sequence contacts involved in poly(A) site definition.

1995 • 128 citations

Neuron-specific alternative RNA processing in transgenic mice expressing a metallothionein-calcitonin fusion gene

1987 • 123 citations

Sequences upstream of AAUAAA influence poly(A) site selection in a complex transcription unit.

1989 • 108 citations

A Uridylate Tract Mediates Efficient Heterogeneous Nuclear Ribonucleoprotein C Protein-RNA Cross-Linking and Functionally Substitutes for the Downstream Element of the Polyadenylation Signal

1990 • 107 citations

Autoregulation of the splicing of transcripts from the transformer-2 gene of Drosophila.

1991 • 102 citations

The Drosophila SR protein RBP1 contributes to the regulation of doublesex alternative splicing by recognizing RBP1 RNA target sequences.

1995 • 100 citations

Alternative splicing of beta-tropomyosin pre-mRNA: cis-acting elements and cellular factors that block the use of a skeletal muscle exon in nonmuscle cells.

1991 • 98 citations

Determination of functional domains in polypyrimidine-tract-binding protein

1998 • 90 citations

The Conserved Pre-mRNA Splicing Factor U2AF from Drosophila : Requirement for Viability

1993 • 89 citations

Upstream sequence elements enhance poly(A) site efficiency of the C2 complement gene and are phylogenetically conserved.

1995 • 89 citations

Autoregulation and multifunctionality among trans-acting factors that regulate alternative pre-mRNA processing.

1992 • 80 citations

Polypyrimidine tract sequences direct selection of alternative branch sites and influence protein binding

1994 • 75 citations

An Intron Enhancer Containing a 5′ Splice Site Sequence in the Human Calcitonin/Calcitonin Gene-Related Peptide Gene

1995 • 74 citations

The use of antibodies to the polypyrimidine tract binding protein (PTB) to analyze the protein components that assemble on alternatively spliced pre-mRNAs that use distant branch points

1998 • 70 citations

Identification of exon sequences and an exon binding protein involved in alternative RNA splicing of calcitonin/CGRP

1992 • 64 citations

Sequence and position requirements for uridylate-rich downstream elements of polyadenylation signals

1994 • 64 citations

Regulation of polyadenylation in hepatitis B viruses: stimulation by the upstream activating signal PS1 is orientation-dependent, distance-independent, and additive

1991 • 59 citations

Sequences Upstream of AAUAAA Influence Poly(A) Site Selection in a Complex Transcription Unit

1989 • 54 citations

Murine polypyrimidine tract binding protein. Purification, cloning, and mapping of the RNA binding domain.

1991 • 54 citations

Control of alternative pre-mRNA splicing by distributed pentameric repeats

1997 • 53 citations

Two Different Sequence Elements within Exon 4 Are Necessary for Calcitonin-Specific Splicing of the Human Calcitonin/Calcitonin Gene-Related Peptide I Pre-mRNA

1994 • 47 citations

Sequence elements upstream of the 3' cleavage site confer substrate strength to the adenovirus L1 and L3 polyadenylation sites.

1994 • 40 citations

Transcription and polyadenylation in a short human intergenic region

1997 • 37 citations

The calcitonin exon and its flanking intronic sequences are sufficient for the regulation of human calcitonin/calcitonin gene-related peptide alternative RNA splicing.

1994 • 28 citations

Upstream and downstream c/s-acting elements for cleavage at the L4 polyadenylation site of adenovirus-2

1994 • 26 citations