Disabled-1 Binds to the Cytoplasmic Domain of Amyloid Precursor-Like Protein 1

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Mode of cell migration to the superficial layers of fetal monkey neocortex

1972 • 2,145 citations

A protein related to extracellular matrix proteins deleted in the mouse mutant reeler

1995 • 1,720 citations

Novel precursor of Alzheimer's disease amyloid protein shows protease inhibitory activity

1988 • 1,093 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Targeted disruption of the cyclin-dependent kinase 5 gene results in abnormal corticogenesis, neuronal pathology and perinatal death.

1996 • 901 citations

Targeting of cell-surface β-amyloid precursor protein to lysosomes: alternative processing into amyloid-bearing fragments

1992 • 883 citations

The reeler gene-associated antigen on cajal-retzius neurons is a crucial molecule for laminar organization of cortical neurons

1995 • 882 citations

Normal and Abnormal Biology of the beta-Amyloid Precursor Protein

1994 • 813 citations

Mice Lacking p35, a Neuronal Specific Activator of Cdk5, Display Cortical Lamination Defects, Seizures, and Adult Lethality

1997 • 727 citations

Neuronal position in the developing brain is regulated by mouse disabled-1

1997 • 698 citations

β-amyloid precursor protein-deficient mice show reactive gliosis and decreased locomotor activity

1995 • 686 citations

Scrambler and yotari disrupt the disabled gene and produce a reeler -like phenotype in mice

1997 • 637 citations

MUTANT GENES IN FAMILIAL ALZHEIMER'S DISEASE AND TRANSGENIC MODELS

1998 • 576 citations

Interaction of Cytosolic Adaptor Proteins with Neuronal Apolipoprotein E Receptors and the Amyloid Precursor Protein

1998 • 544 citations

Two new mutants, ‘trembler’ and ‘reeler’, with neurological actions in the house mouse (Mus musculus L.)

1951 • 517 citations

Reelin Is a Secreted Glycoprotein Recognized by the CR-50 Monoclonal Antibody

1997 • 512 citations

The cells and molecules that make a cerebellum

1998 • 506 citations

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein

1996 • 480 citations

The secreted form of the Alzheimer's amyloid precursor protein with the Kunitz domain is protease nexin-II

1989 • 460 citations

Reverse two-hybrid and one-hybrid systems to detect dissociation of protein-protein and DNA-protein interactions.

1996 • 424 citations

Identification of a mouse brain cDNA that encodes a protein related to the Alzheimer disease-associated amyloid beta protein precursor.

1992 • 395 citations

A heparin-binding domain in the amyloid protein precursor of Alzheimer's disease is involved in the regulation of neurite outgrowth

1994 • 393 citations

Isolation and characterization of APLP2 encoding a homologue of the Alzheimer's associated amyloid β protein precursor

1993 • 388 citations

The Disabled 1 Phosphotyrosine-Binding Domain Binds to the Internalization Signals of Transmembrane Glycoproteins and to Phospholipids

1999 • 381 citations

Disabled-1 acts downstream of Reelin in a signaling pathway that controls laminar organization in the mammalian brain

1998 • 370 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

Mouse disabled (mDab1): a Src binding protein implicated in neuronal development

1997 • 337 citations

Impaired learning and LTP in mice expressing the carboxy terminus of the Alzheimer amyloid precursor protein

1997 • 331 citations

Generation of APLP2 KO Mice and Early Postnatal Lethality in APLP2/APP Double KO Mice

1997 • 327 citations

The PTB domain: a new protein module implicated in signal transduction

1995 • 249 citations

Physiology and pathology of tau protein kinases in relation to Alzheimer's disease.

1997 • 232 citations

Accumulation of cyclin-dependent kinase 5 (cdk5) in neurons with early stages of Alzheimer's disease neurofibrillary degeneration

1998 • 227 citations

The X11α Protein Slows Cellular Amyloid Precursor Protein Processing and Reduces Aβ40 and Aβ42 Secretion

1998 • 198 citations

Cell-surface beta-amyloid precursor protein stimulates neurite outgrowth of hippocampal neurons in an isoform-dependent manner

1995 • 196 citations

Characterization of Sorting Signals in the β-Amyloid Precursor Protein Cytoplasmic Domain

1995 • 194 citations

Increased expression of beta-amyloid precursor protein during neuronal differentiation is not accompanied by secretory cleavage.

1992 • 180 citations

Expression in mouse embryos and in adult mouse brain of three members of the amyloid precursor protein family, of the alpha-2-macroglobulin receptor/low density lipoprotein receptor-related protein and of its ligands apolipoprotein E, lipoprotein lipase, alpha-2-macroglobulin and the 40,000 molecular weight receptor-associated protein

1995 • 166 citations

Association of a novel human FE65-like protein with the cytoplasmic domain of the beta-amyloid precursor protein.

1996 • 159 citations

The Amyloid Precursor Protein Is Developmentally Regulated and Correlated with Synaptogenesis

1994 • 158 citations

Scrambler, a new neurological mutation of the mouse with abnormalities of neuronal migration

1996 • 154 citations

Reeler: new tales on an old mutant mouse

1998 • 154 citations

A novel neurological mutant mouse, yotari, which exhibits reeler-like phenotype but expresses CR-50 antigen/Reelin

1997 • 138 citations

cDNA cloning and chromosome mapping of the human Fe65 gene: interaction of the conserved cytoplasmic domains of the human beta-amyloid precursor protein and its homologues with the mouse Fe65 protein

1996 • 120 citations

Retinoic acid induced differentiated neuroblastoma cells show increased expression of the βA4 amyloid gene of Alzheimer's disease and an altered splicing pattern

1990 • 107 citations

Amyloid β-protein precursor is associated with extracellular matrix

1990 • 106 citations

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

1996 • 104 citations

Distribution of an APP homolog, APLP2, in the mouse olfactory system: a potential role for APLP2 in axogenesis

1995 • 87 citations

Numb-Associated Kinase Interacts with the Phosphotyrosine Binding Domain of Numb and Antagonizes the Function of Numb In Vivo

1998 • 71 citations

Increased gene expression of β-amyloid precursor protein and its homologues APLP1 and APLP2 in human neuroblastoma cells in response to retinoic acid

1997 • 48 citations

Novel Domain-Specific Actions of Amyloid Precursor Protein on Developing Synapses

1998 • 41 citations

Amyloid precursor protein is enriched in radial glia: Implications for neuronal development

1994 • 39 citations

Deletion of an Endosomal/Lysosomal Targeting Signal Promotes the Secretion of Alzheimer's Disease Amyloid Precursor Protein (APP)

1997 • 21 citations

Reeler: new tales on an old mutant mouse

1998 • 11 citations