Numb-Associated Kinase Interacts with the Phosphotyrosine Binding Domain of Numb and Antagonizes the Function of Numb In Vivo

Targeted gene expression as a means of altering cell fates and generating dominant phenotypes

1993 • 9,476 citations

Genetic Transformation of Drosophila with Transposable Element Vectors

1982 • 2,995 citations

Drosophila: A laboratory handbook

1990 • 1,742 citations

The two-hybrid system: a method to identify and clone genes for proteins that interact with a protein of interest.

1991 • 1,489 citations

The retinoblastoma protein associates with the protein phosphatase type 1 catalytic subunit.

1993 • 1,459 citations

par-1, a gene required for establishing polarity in C. elegans embryos, encodes a putative Ser/Thr kinase that is asymmetrically distributed

1995 • 1,099 citations

Asymmetric distribution of numb protein during division of the sensory organ precursor cell confers distinct fates to daughter cells

1994 • 749 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

Identification of a New Family of Tissue-Specific Basic Helix-Loop-Helix Proteins with a Two-Hybrid System

1995 • 655 citations

Structure of the high affinity complex of inositol trisphosphate with a phospholipase C pleckstrin homology domain

1995 • 597 citations

Suppressor of hairless directly activates transcription of enhancer of split complex genes in response to Notch receptor activity.

1995 • 594 citations

A novel genetic system to detect protein-protein interactions

1991 • 532 citations

Mechanisms of asymmetric cell division: Two Bs or not two Bs, that is the question

1992 • 527 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

numb, a gene required in determination of cell fate during sensory organ formation in Drosophila embryos

1989 • 493 citations

Asymmetric segregation of Numb and Prospero during cell division

1995 • 489 citations

The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein

1996 • 480 citations

Asymmetric Localization of a Mammalian Numb Homolog during Mouse Cortical Neurogenesis

1996 • 479 citations

Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins.

1993 • 476 citations

PH Domains: Diverse Sequences with a Common Fold Recruit Signaling Molecules to the Cell Surface

1996 • 464 citations

Neuronal development in the drosophila retina: Monoclonal antibodies as molecular probes

1984 • 430 citations

The neurogenic suppressor of hairless DNA-binding protein mediates the transcriptional activation of the enhancer of split complex genes triggered by Notch signaling.

1995 • 430 citations

Numb Antagonizes Notch Signaling to Specify Sibling Neuron Cell Fates

1996 • 415 citations

Using the two-hybrid system to detect protein-protein interactions

1993 • 414 citations

Development of adult sensilla on the wing and notum of Drosophila melanogaster

1989 • 383 citations

The conserved Schizosaccharomyces pombe kinase plo1, required to form a bipolar spindle, the actin ring, and septum, can drive septum formation in G1 and G2 cells.

1995 • 376 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

prospero is expressed in neuronal precursors and encodes a nuclear protein that is involved in the control of axonal outgrowth in Drosophila

1991 • 360 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

A dual function of the Notch gene in Drosophila sensillum development

1990 • 333 citations

Structure of the IRS-1 PTB Domain Bound to the Juxtamembrane Region of the Insulin Receptor

1996 • 314 citations

The Drosophila Numb protein inhibits signaling of the Notch receptor during cell-cell interaction in sensory organ lineage.

1996 • 313 citations

The basic-helix-loop-helix domain of Drosophila lethal of scute protein is sufficient for proneural function and activates neurogenic genes

1994 • 306 citations

Differential expression of mammalian Numb, Numblike and Notch1 suggests distinct roles during mouse cortical neurogenesis

1997 • 278 citations

A non-muscle myosin required for embryonic polarity in Caenorhabditis elegans

1996 • 262 citations

Asymmetric localization of numb autonomously determines sibling neuron identity in the Drosophila CNS

1995 • 249 citations

PTB Domain Binding to Signaling Proteins Through a Sequence Motif Containing Phosphotyrosine

1995 • 245 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Maggot's hair and bug's eye: Role of cell interactions and intrinsic factors in cell fate specification

1995 • 180 citations

Peptide–Surface Association: The Case of PDZ and PTB Domains

1996 • 178 citations

Mammalian NUMB is an evolutionarily conserved signaling adapter protein that specifies cell fate

1996 • 159 citations

Nature versus nurture: Asymmetric cell divisions in Drosophila bristle development

1994 • 155 citations

Antagonistic activities of Suppressor of Hairless and Hairless control alternative cell fates in the Drosophila adult epidermis

1994 • 144 citations

Interaction of Insulin Receptor Substrate-2 (IRS-2) with the Insulin and Insulin-like Growth Factor I Receptors

1996 • 133 citations

Origin and specification of type II sensory neurons in Drosophila

1995 • 132 citations

tramtrack acts downstream of numb to specify distinct daughter cell fates during asymmetric cell divisions in the drosophila PNS

1995 • 110 citations

Delta Function Is Required for Bristle Organ Determination and Morphogenesis in Drosophila

1993 • 106 citations

Distinct Modes of Interaction of SHC and Insulin Receptor Substrate-1 with the Insulin Receptor NPEY Region via Non-SH2 Domains

1995 • 90 citations

Phosphotyrosine-independent Binding of SHC to the NPLH Sequence of Murine Protein-tyrosine Phosphatase-PEST

1996 • 78 citations

High-affinity binding of the Drosophila Numb phosphotyrosine-binding domain to peptides containing a Gly-Pro-(p)Tyr motif

1997 • 67 citations

Numb Diverts Notch Pathway Off the Tramtrack

1996 • 61 citations

Inhibition of cell fate in Drosophila by Enhancer of split genes

1995 • 53 citations

Drosophila terminal structure development is regulated by the compensatory activities of positive and negative phosphotyrosine signaling sites on the Torso RTK.

1996 • 44 citations

The Drosophila melanogaster stranded at second (sas) gene encodes a putative epidermal cell surface receptor required for larval development

1992 • 36 citations