The Phosphotyrosine Interaction Domains of X11 and FE65 Bind to Distinct Sites on the YENPTY Motif of Amyloid Precursor Protein

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor

1987 • 4,544 citations

Amyloid plaque core protein in Alzheimer disease and Down syndrome.

1985 • 4,276 citations

Protein modules and signalling networks

1995 • 2,447 citations

Domain Interaction Between NMDA Receptor Subunits and the Postsynaptic Density Protein PSD-95

1995 • 1,861 citations

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling

1992 • 1,636 citations

Alzheimer's disease and Down's syndrome: Sharing of a unique cerebrovascular amyloid fibril protein

1984 • 1,633 citations

Interaction of Nitric Oxide Synthase with the Postsynaptic Density Protein PSD-95 and α1-Syntrophin Mediated by PDZ Domains

1996 • 1,589 citations

Protein tyrosine kinase PYK2 involved in Ca2+-induced regulation of ion channel and MAP kinase functions

1995 • 1,367 citations

A novel transforming protein (SHC) with an SH2 domain is implicated in mitogenic signal transduction

1992 • 1,358 citations

Crystal Structures of a Complexed and Peptide-Free Membrane Protein–Binding Domain: Molecular Basis of Peptide Recognition by PDZ

1996 • 1,127 citations

Association of the Shc and Grb2/Sem5 SH2-containing proteins is implicated in activation of the Ras pathway by tyrosine kinases

1992 • 998 citations

Evidence that production and release of amyloid beta-protein involves the endocytic pathway

1994 • 984 citations

Nitric oxide synthase complexed with dystrophin and absent from skeletal muscle sarcolemma in Duchenne muscular dystrophy

1995 • 954 citations

NPXY, a sequence often found in cytoplasmic tails, is required for coated pit-mediated internalization of the low density lipoprotein receptor.

1990 • 944 citations

Specific motifs recognized by the SH2 domains of Csk, 3BP2, fps/fes, GRB-2, HCP, SHC, Syk, and Vav.

1994 • 886 citations

WW domains of Nedd4 bind to the proline-rich PY motifs in the epithelial Na+ channel deleted in Liddle's syndrome.

1996 • 828 citations

EGF induces tyrosine phosphorylation of phospholipase C-II: A potential mechanism for EGF receptor signaling

1989 • 784 citations

FAP-1: A Protein Tyrosine Phosphatase That Associates with Fas

1995 • 702 citations

Crystal structure of the phosphotyrosine recognition domain SH2 of v-src complexed with tyrosine-phosphorylated peptides

1992 • 684 citations

Control of Daughter Cell Fates during Asymmetric Division: Interaction of Numb and Notch

1996 • 656 citations

Cloning of PI3 kinase-associated p85 utilizing a novel method for expression/cloning of target proteins for receptor tyrosine kinases

1991 • 641 citations

The WW domain of Yes-associated protein binds a proline-rich ligand that differs from the consensus established for Src homology 3-binding modules.

1995 • 556 citations

An Alternative to SH2 Domains for Binding Tyrosine-Phosphorylated Proteins

1994 • 501 citations

beta-Amyloid peptide and a 3-kDa fragment are derived by distinct cellular mechanisms.

1993 • 460 citations

SH2/SH3 signaling proteins

1994 • 457 citations

Processing of Alzheimer beta/A4 amyloid precursor protein: modulation by agents that regulate protein phosphorylation.

1990 • 453 citations

Hierarchy of binding sites for Grb2 and Shc on the epidermal growth factor receptor.

1994 • 450 citations

Phosphotyrosine-Dependent Interaction of SHC and Insulin Receptor Substrate 1 with the NPEY Motif of the Insulin Receptor via a Novel Non-SH2 Domain

1995 • 368 citations

Characterization of a novel protein‐binding module — the WW domain

1995 • 365 citations

Structure and ligand recognition of the phosphotyrosine binding domain of Shc

1995 • 361 citations

A region in Shc distinct from the SH2 domain can bind tyrosine-phosphorylated growth factor receptors.

1994 • 334 citations

Characterization of the Mammalian YAP (Yes-associated Protein) Gene and Its Role in Defining a Novel Protein Module, the WW Domain

1995 • 326 citations

The tyrosine phosphorylated carboxyterminus of the EGF receptor is a binding site for GAP and PLC-gamma.

1990 • 314 citations

The Regions of the Fe65 Protein Homologous to the Phosphotyrosine Interaction/Phosphotyrosine Binding Domain of Shc Bind the Intracellular Domain of the Alzheimer's Amyloid Precursor Protein

1995 • 295 citations

Multiple cytokines induce the tyrosine phosphorylation of Shc and its association with Grb2 in hemopoietic cells.

1993 • 238 citations

PTB Domains of IRS-1 and Shc Have Distinct but Overlapping Binding Specificities

1995 • 220 citations

Identification of the Alzheimer beta/A4 amyloid precursor protein in clathrin-coated vesicles purified from PC12 cells.

1993 • 213 citations

Characterization of Sorting Signals in the β-Amyloid Precursor Protein Cytoplasmic Domain

1995 • 194 citations

A conserved amino-terminal Shc domain binds to phosphotyrosine motifs in activated receptors and phosphopeptides

1995 • 174 citations

High-efficiency expression/cloning of epidermal growth factor-receptor-binding proteins with Src homology 2 domains.

1992 • 170 citations

Growth Hormone-promoted Tyrosyl Phosphorylation of SHC Proteins and SHC Association with Grb2

1995 • 168 citations

Non-SH2 Domains within Insulin Receptor Substrate-1 and SHC Mediate Their Phosphotyrosine-dependent Interaction with the NPEY Motif of the Insulin-like Growth Factor I Receptor

1995 • 166 citations

Study of the synthesis and secretion of normal and artificial mutants of murine amyloid precursor protein (APP): cleavage of APP occurs in a late compartment of the default secretion pathway.

1993 • 152 citations

Shc Binding to Nerve Growth Factor Receptor Is Mediated by the Phosphotyrosine Interaction Domain

1995 • 138 citations

The Phosphotyrosine Interaction Domain of Shc Binds an LXNPXY Motif on the Epidermal Growth Factor Receptor

1995 • 137 citations

pGSTag--a versatile bacterial expression plasmid for enzymatic labeling of recombinant proteins.

1992 • 136 citations

The cloning of Grb10 reveals a new family of SH2 domain proteins.

1995 • 130 citations

Evidence for a Differential Interaction of SHC and the Insulin Receptor Substrate-1 (IRS-1) with the Insulin-like Growth Factor-I (IGF-I) Receptor in the Yeast Two-hybrid System

1995 • 117 citations

Shc adaptor proteins are key transducers of mitogenic signaling mediated by the G protein-coupled thrombin receptor.

1996 • 112 citations

Identification of residues that control specific binding of the Shc phosphotyrosine-binding domain to phosphotyrosine sites.

1996 • 104 citations

A rat brain mRNA encoding a transcriptional activator homologous to the DNA binding domain of retroviral integrases

1991 • 97 citations

Distinct Modes of Interaction of SHC and Insulin Receptor Substrate-1 with the Insulin Receptor NPEY Region via Non-SH2 Domains

1995 • 90 citations

Phosphotyrosine-independent Binding of SHC to the NPLH Sequence of Murine Protein-tyrosine Phosphatase-PEST

1996 • 78 citations

Gene in the region of the Friedreich ataxia locus encodes a putative transmembrane protein expressed in the nervous system.

1993 • 69 citations

Interaction between the Phosphotyrosine Binding Domain of Shc and the Insulin Receptor Is Required for Shc Phosphorylation by Insulin in Vivo

1996 • 63 citations

Expression of the Neuron-Specific FE65 Gene Marks the Development of Embryo Ganglionic Derivatives

1994 • 37 citations

Identification of Residues within the SHC Phosphotyrosine Binding/Phosphotyrosine Interaction Domain Crucial for Phosphopeptide Interaction

1996 • 36 citations