Thrombopoietin Signal Transduction in Purified Murine Megakaryocytes

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Cytokine receptor signalling

1995 • 1,242 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions

1994 • 813 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

Interleukin-3, granulocyte-macrophage colony stimulating factor and interleukin-5 transduce signals through two STAT5 homologs.

1995 • 641 citations

Requirement of Serine Phosphorylation for Formation of STAT-Promoter Complexes

1995 • 578 citations

Human interleukin 6 is a direct promoter of maturation of megakaryocytes in vitro.

1989 • 430 citations

Contribution of STAT SH2 Groups to Specific Interferon Signaling by the Jak-STAT pathway

1995 • 428 citations

Thrombopoietin, the Mp1 ligand, is essential for full megakaryocyte development.

1995 • 333 citations

Erythropoietin Induces Activation of Stat5 through Association with Specific Tyrosines on the Receptor That Are Not Required for a Mitogenic Response

1996 • 272 citations

The interleukin-6-activated acute-phase response factor is antigenically and functionally related to members of the signal transducer and activator of transcription (STAT) family.

1994 • 251 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

STAT3 activation by cytokines utilizing gp130 and related transducers involves a secondary modification requiring an H7-sensitive kinase.

1995 • 211 citations

Thrombopoietin induces tyrosine phosphorylation of Stat3 and Stat5 in human blood platelets

1996 • 189 citations

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.

1995 • 183 citations

The thrombopoietin receptor c-MPL activates JAK2 and TYK2 tyrosine kinases.

1995 • 170 citations

Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets

1995 • 148 citations

Thrombopoietin, c-Mpl ligand, induces tyrosine phosphorylation of Tyk2, JAK2, and STAT3, and enhances agonists-induced aggregation in platelets in vitro

1995 • 145 citations

Interleukin-3, Erythropoietin, and Prolactin Activate a STAT5-like Factor in Lymphoid Cells

1995 • 128 citations

Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2

1995 • 97 citations

Granulocyte colony-stimulating factor rapidly activates a distinct STAT- like protein in normal myeloid cells

1995 • 84 citations

Effect of thrombopoietin on the development of megakaryocytes and platelets: an ultrastructural analysis

1996 • 83 citations

Thrombopoietin (TPO) induces tyrosine phosphorylation and activation of STAT5 and STAT3

1995 • 77 citations

The Molecular Biology of Interleukin 6 and its Receptor

2007 • 68 citations

Interleukin 5 and its receptor

1991 • 63 citations

TPO/c-mpl Ligand Induces Tyrosine Phosphorylation of Multiple Cellular Proteins Including Proto-oncogene Products, Vav and c-Cbl, and Ras Signaling Molecules

1995 • 63 citations

Megakaryocyte growth and development factor and interleukin-3 induce patterns of protein-tyrosine phosphorylation that correlate with dominant differentiation over proliferation of mpl-transfected 32D cells

1995 • 60 citations

Biological and biochemical characteristics of murine megakaryoblastic cell line L8057.

1993 • 55 citations

Thrombopoietin stimulates colony-forming unit-megakaryocyte proliferation and megakaryocyte maturation independently of cytokines that signal through the gp130 receptor subunit

1996 • 41 citations

Interleukin-11 and its receptor.

1992 • 39 citations

Signaling by the cytoplasmic domain of hematopoietin receptors involves two distinguishable mechanisms in hepatic cells.

1994 • 39 citations

Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity

1994 • 30 citations

TPO and IL-3 Induce Overlapping but Distinct Protein Tyrosine Phosphorylation in a Myeloid Precursor Cell Line

1995 • 19 citations

Development of a cell line dependent on MPL ligand for proliferation

1994 • 3 citations