Functional Regions of the Mouse Thrombopoietin Receptor Cytoplasmic Domain: Evidence for a Critical Region Which Is Involved in Differentiation and Can Be Complemented by Erythropoietin

Advanced mammalian gene transfer: high titre retroviral vectors with multiple drug selection markers and a complementary helper-free packaging cell line

1990 • 2,129 citations

Maximal activation of transcription by statl and stat3 requires both tyrosine and serine phosphorylation

1995 • 1,960 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

Cytokine receptor signalling

1995 • 1,242 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

A Short Polypeptide Marker Sequence Useful for Recombinant Protein Identification and Purification

1988 • 934 citations

Thrombopoietin: the primary regulator of platelet production [see comments]

1995 • 691 citations

c-Mpl ligand is a humoral regulator of megakaryocytopoiesis

1994 • 689 citations

Thrombocytopenia in c-mpl-deficient mice

1994 • 680 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Ligand-induced IFN gamma receptor tyrosine phosphorylation couples the receptor to its signal transduction system (p91).

1994 • 453 citations

Megakaryocytic and erythrocytic lineages share specific transcription factors

1990 • 446 citations

Thrombopoietin (c-mpl ligand) acts synergistically with erythropoietin, stem cell factor, and interleukin-11 to enhance murine megakaryocyte colony growth and increases megakaryocyte ploidy in vitro

1995 • 416 citations

A putative truncated cytokine receptor gene transduced by the myeloproliferative leukemia virus immortalizes hematopoietic progenitors

1990 • 404 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Selective growth response to IL‐3 of a human leukaemic cell line with megakaryoblastic features

1988 • 314 citations

Establishment and characterization of a human leukemic cell line with megakaryocytic features: dependency on granulocyte-macrophage colony-stimulating factor, interleukin 3, or erythropoietin for growth and survival.

1991 • 309 citations

Interaction of the erythropoietin and stem-cell-factor receptors

1995 • 309 citations

Characterization of a new megakaryocytic cell line: the Dami cell

1988 • 286 citations

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets

1995 • 286 citations

Growth and differentiation signals mediated by different regions in the cytoplasmic domain of granulocyte colony-stimulating factor receptor

1993 • 283 citations

Thrombopoietin expands erythroid progenitors, increases red cell production, and enhances erythroid recovery after myelosuppressive therapy.

1995 • 269 citations

The ubiquitous subunit of erythroid transcription factor NF-E2 is a small basic-leucine zipper protein related to the v-maf oncogene.

1993 • 260 citations

Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.

1993 • 246 citations

The c-Mpl Ligand (Thrombopoietin) Stimulates Tyrosine Phosphorylation of Jak2, Shc, and c-Mpl

1995 • 235 citations

Expression of tal-1 and GATA-binding proteins during human hematopoiesis

1993 • 233 citations

Characterization of a new megakaryocytic cell line: the Dami cell

1988 • 220 citations

Thrombopoietin activates a STAT5-like factor in hematopoietic cells.

1995 • 218 citations

Distinct regions of c-Mpl cytoplasmic domain are coupled to the JAK-STAT signal transduction pathway and Shc phosphorylation.

1995 • 183 citations

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7

1993 • 175 citations

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

1993 • 174 citations

Recombinant human thrombopoietin (Mpl ligand) enhances proliferation of erythroid progenitors

1995 • 157 citations

Establishment and characterization of an erythropoietin-dependent subline, UT-7/Epo, derived from human leukemia cell line, UT-7

1993 • 155 citations

Human thrombopoietin: gene structure, cDNA sequence, expression, and chromosomal localization.

1994 • 147 citations

Distinct Regions of the Human Granulocyte-Colony-Stimulating Factor Receptor Cytoplasmic Domain Are Required for Proliferation and Gene Induction

1993 • 138 citations

Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.

1993 • 134 citations

Expression of specific high-affinity binding sites for erythropoietin on rat and mouse megakaryocytes.

1989 • 129 citations

Distinct cytoplasmic regions of the growth hormone receptor are required for activation of JAK2, mitogen-activated protein kinase, and transcription.

1994 • 120 citations

Functional Regions of the Mouse Interleukin-10 Receptor Cytoplasmic Domain

1995 • 111 citations

Multiple regions within the cytoplasmic domains of the leukemia inhibitory factor receptor and gp130 cooperate in signal transduction in hepatic and neuronal cells

1994 • 109 citations

Differentiation-Regulated Serine Phosphorylation of STAT1 Promotes GAF Activation in Macrophages

1995 • 101 citations

Megakaryocytic and erythrocytic cell lines share a common precursor cell.

1993 • 97 citations

Thrombopoietin induces tyrosine phosphorylation and activation of the Janus kinase, JAK2

1995 • 97 citations

Granulocyte-macrophage colony-stimulating factor and erythropoietin act competitively to induce two different programs of differentiation in the human pluripotent cell line UT-7

1992 • 61 citations

Thrombopoietin Induces Megakaryocyte Differentiation in Hematopoietic Progenitor FDC-P2 Cells

1995 • 57 citations

Signal transduction by the receptors for thrombopoietin (c-mpL) and interleukin-3 in hematopoietic and nonhematopoietic cells

1995 • 46 citations

Human megakaryocytopoiesis: In vitro regulation and characterization of megakaryocytic precursor cells by differentiation markers

1988 • 44 citations

Thrombocytopoietic properties of oncostatin M

1995 • 42 citations

Interleukin-6 and erythropoietin act as direct potentiators and inducers of in vitro cytoplasmic process formation on purified mouse megakaryocytes.

1994 • 40 citations

Myeloid progenitor cells transformed by the myeloproliferative leukemia virus proliferate and differentiate in vitro without the addition of growth factors.

1989 • 39 citations

Characterization of mpl cytoplasmic domain sequences required for myeloproliferative leukemia virus pathogenicity

1994 • 30 citations

Transient effect of erythropoietin on thrombocytopoiesis in vivo in mice.

1992 • 27 citations

Interactions between recombinant human erythropoietin and serum factor(s) on murine megakaryocyte colony formation

1992 • 22 citations

Interactions between recombinant human erythropoietin and serum factor(s) on murine megakaryocyte colony formation

1992 • 19 citations

Constitutive activation of a variant of the env-mpl oncogene product by disulfide-linked homodimerization

1995 • 18 citations

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