Recombinant thrombopoietin induces rapid protein tyrosine phosphorylation of Janus kinase 2 and Shc in human blood platelets

Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4

1970 • 253,849 citations

Jak-STAT Pathways and Transcriptional Activation in Response to IFNs and Other Extracellular Signaling Proteins

1994 • 5,932 citations

Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand

1994 • 1,328 citations

JAK2 associates with the erythropoietin receptor and is tyrosine phosphorylated and activated following stimulation with erythropoietin

1993 • 1,223 citations

Cloning and expression of murine thrombopoietin cDNA and stimulation of platelet production in vivo

1994 • 1,138 citations

Promotion of megakaryocyte progenitor expansion and differentiation by the c-Mpl ligand thrombopoietin

1994 • 1,081 citations

Identification and cloning of a megakaryocyte growth and development factor that is a ligand for the cytokine receptor MpI

1994 • 987 citations

Molecular cloning and characterization of MPL, the human homolog of the v-mpl oncogene: identification of a member of the hematopoietic growth factor receptor superfamily.

1992 • 525 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 359 citations

Ciliary neurotrophic factor/leukemia inhibitory factor/interleukin 6/oncostatin M family of cytokines induces tyrosine phosphorylation of a common set of proteins overlapping those induced by other cytokines and growth factors

1994 • 359 citations

The Mpl receptor is expressed in the megakaryocytic lineage from late progenitors to platelets

1995 • 286 citations

Molecular cloning and chromosomal localization of the human thrombopoietin gene

1994 • 237 citations

Tyrosine phosphorylation of pp125FAK in platelets requires coordinated signaling through integrin and agonist receptors.

1994 • 233 citations

Regulation of the protein tyrosine kinase pp72syk by platelet agonists and the integrin alpha IIb beta 3.

1994 • 227 citations

Activation of the mitogen-activated protein kinase pathway by the erythropoietin receptor.

1994 • 220 citations

Murine c-mpl: a member of the hematopoietic growth factor receptor superfamily that transduces a proliferative signal.

1993 • 174 citations

Characterization of the murine Mpl proto-oncogene, a member of the hematopoietic cytokine receptor family: molecular cloning, chromosomal location and evidence for a function in cell growth.

1993 • 134 citations

Association of pp60src with Triton X-100-insoluble residue in human blood platelets requires platelet aggregation and actin polymerization.

1992 • 81 citations

The Janus Kinase Family and Signaling Through Members of the Cytokine Receptor Superfamily

1994 • 75 citations

The extended box 2 subdomain of erythropoietin receptor is nonessential for Jak2 activation yet critical for efficient mitogenesis in FDC-ER cells

1994 • 61 citations

A dominant negative erythropoietin (EPO) receptor inhibits EPO-dependent growth and blocks F-gp55-dependent transformation.

1994 • 57 citations

Phosphorylation of JAK2 in thrombin‐stimulated human platelets

1994 • 53 citations

Identification of a 130-kilodalton tyrosine-phosphorylated protein induced by interleukin-11 as JAK2 tyrosine kinase, which associates with gp130 signal transducer.

1994 • 52 citations

2 Cytokine receptors and signal transduction

1994 • 52 citations

Oligodeoxynucleotides antisense to the proto-oncogene c-mpl specifically inhibit in vitro megakaryocytopoiesis

1993 • 31 citations

Inhibition by sodium nitroprusside or PGE1 of tyrosine phosphorylation induced in platelets by thrombin or ADP

1992 • 26 citations

Dominant Negative Effects of a Carboxy-Truncated Jak2 Mutant on Epo-Induced Proliferation and Jak2 Activation

1994 • 18 citations

A Dominant Negative Erythropoietin (EPO) Receptor Inhibits EPO-Dependent Growth and Blocks F-gp55-Dependent Transformation

1994 • 11 citations