Megakaryocytic Differentiation Induced by Constitutive Activation of Mitogen-Activated Protein Kinase Kinase

Opposing Effects of ERK and JNK-p38 MAP Kinases on Apoptosis

1995 • 5,334 citations

Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation

1995 • 4,589 citations

The MAPK signaling cascade

1995 • 3,300 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,865 citations

A reagent for the single-step simultaneous isolation of RNA, DNA and proteins from cell and tissue samples.

1993 • 2,807 citations

A synthetic inhibitor of the mitogen-activated protein kinase cascade.

1995 • 2,723 citations

Human chronic myelogenous leukemia cell-line with positive Philadelphia chromosome

1975 • 2,228 citations

The mitogen-activated protein kinase signal transduction pathway

1993 • 2,174 citations

Activation of MAP kinase kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells

1994 • 1,999 citations

Molecular themes in oncogenesis

1991 • 1,663 citations

Transformation of Mammalian Cells by Constitutively Active MAP Kinase Kinase

1994 • 1,370 citations

The molecular control of cell division, differentiation commitment and maturation in haemopoietic cells

1989 • 1,097 citations

Insulin-stimulated MAP-2 kinase phosphorylates and activates ribosomal protein S6 kinase II

1988 • 1,032 citations

Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation.

1993 • 992 citations

Inhibition of MAP Kinase Kinase Blocks the Differentiation of PC-12 Cells Induced by Nerve Growth Factor

1995 • 906 citations

Sustained activation of the mitogen-activated protein (MAP) kinase cascade may be required for differentiation of PC12 cells. Comparison of the effects of nerve growth factor and epidermal growth factor

1992 • 885 citations

The activities of two Ets-related transcription factors required for drosophila eye development are modulated by the Ras/MAPK pathway

1994 • 690 citations

Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts

1993 • 668 citations

K562 human leukaemic cells synthesise embryonic haemoglobin in response to haemin

1979 • 532 citations

Regulation and properties of extracellular signal-regulated protein kinases 1 and 2 in vitro.

1993 • 503 citations

MAPKAP kinase-2; a novel protein kinase activated by mitogen-activated protein kinase.

1992 • 486 citations

PC12 cell neuronal differentiation is associated with prolonged p21ras activity and consequent prolonged ERK activity

1992 • 480 citations

Selective requirement for MAP kinase activation in thymocyte differentiation

1995 • 398 citations

Cloning and characterization of two distinct human extracellular signal-regulated kinase activator kinases, MEK1 and MEK2

1993 • 333 citations

Requirements for Phosphorylation of Map Kinase During Meiosis in Xenopus Oocytes

1992 • 316 citations

Mesoderm induction in Xenopus caused by activation of MAP kinase

1995 • 223 citations

Constitutively active mutants of MAP kinase kinase (MEK1) induce growth factor-relaxation and oncogenicity when expressed in fibroblasts.

1994 • 222 citations

Overexpression of mitogen-activated protein kinase kinase (MAPKK) and its mutants in NIH 3T3 cells. Evidence that MAPKK involvement in cellular proliferation is regulated by phosphorylation of serine residues in its kinase subdomains VII and VIII.

1994 • 218 citations

A requirement for extracellular signal-regulated kinase (ERK) function in the activation of AP-1 by Ha-Ras, phorbol 12-myristate 13-acetate, and serum.

1994 • 214 citations

GATA-1 but not SCL induces megakaryocytic differentiation in an early myeloid line.

1992 • 196 citations

Inhibition of v-raf-dependent c-fos expression and transformation by a kinase-defective mutant of the mitogen-activated protein kinase Erk2.

1994 • 186 citations

Embryonic erythroid differentiation in the human leukemic cell line K562.

1981 • 183 citations

Megakaryoblastic differentiation of proerythroblastic K562 cell-line cells

1984 • 178 citations

Cis-acting sequences regulating expression of the human α-globin cluster lie within constitutively open chromatin

1992 • 162 citations

Phosphorylation of c-Fos at the C-terminus enhances its transforming activity.

1996 • 159 citations

Induced differentiation of K562 leukemia cells: A model for studies of gene expression in early megakaryoblasts

1990 • 155 citations

Transcriptional Regulation of Globin Gene Expression in the Human Erythroid Cell Line K562

1983 • 149 citations

Interdependent Domains Controlling the Enzymatic Activity of Mitogen-Activated Protein Kinase Kinase 1

1996 • 134 citations

Selective Activation of MEK1 but Not MEK2 by A-Raf from Epidermal Growth Factor-stimulated Hela Cells

1996 • 120 citations

The Cell Cycle in Polyploid Megakaryocytes Is Associated with Reduced Activity of Cyclin B1-dependent Cdc2 Kinase

1996 • 113 citations

Stimulation of MAP-2 kinase activity in T lymphocytes by anti-CD3 or anti-Ti monoclonal antibody is partially dependent on protein kinase C.

1990 • 112 citations

Signalling pathways initiated by receptor protein tyrosine kinases in Drosophila

1994 • 102 citations

Regulation of GATA-2 Phosphorylation by Mitogen-activated Protein Kinase and Interleukin-3

1995 • 101 citations

Contrasting effects of alpha and beta globin regulatory elements on chromatin structure may be related to their different chromosomal environments.

1995 • 95 citations

3pK, a New Mitogen-Activated Protein Kinase-Activated Protein Kinase Located in the Small Cell Lung Cancer Tumor Suppressor Gene Region

1996 • 92 citations

Characterization of a specific erythromegakaryocytic enhancer within the glycoprotein IIb promoter.

1992 • 77 citations

Control and integration of cell signaling pathways during C. Elegans vulval development

1996 • 70 citations

Differential regulation of Max and role of c-Myc during erythroid and myelomonocytic differentiation of K562 cells.

1995 • 64 citations

Constitutively active mitogen-activated protein kinase kinase 1 (MAPKK1) and MAPKK2 mediate similar transcriptional and morphological responses.

1996 • 62 citations

MAP kinase activation is essential for oncogenic transformation of NIH3T3 cells by Mos.

1995 • 61 citations

Thrombopoietin Induces Tyrosine Phosphorylation and Activation of Mitogen-Activated Protein Kinases in a Human Thrombopoietin-Dependent Cell Line

1995 • 59 citations

Induced cell surface expression of functional α2β1 integrin during megakaryocytic differentiation of K562 leukemic cells

1992 • 57 citations

The role of MAP kinase kinase in interleukin-3 stimulation of proliferation

1996 • 56 citations

Transcriptional regulation of alpha IIb integrin gene expression during megakaryocytic differentiation of K562 cells. Role of a silencer element

1994 • 55 citations

Negative Regulation of Globin Gene Expression during Megakaryocytic Differentiation of a Human Erythroleukemic Cell Line

1991 • 54 citations

Megakaryocytopoiesis: The State of the Art

1995 • 53 citations

Overexpression of cyclin D1 in the Dami megakaryocytic cell line causes growth arrest

1995 • 53 citations

Rapid activation of the MAP kinase pathway in hematopoietic cells by erythropoietin, granulocyte-macrophage colony-stimulating factor and interleukin-3

1994 • 49 citations

Platelet adhesion receptors

1995 • 45 citations

Differential regulation of the alpha 2 beta 1 and alpha IIb beta 3 integrin genes during megakaryocytic differentiation of pluripotential K562 cells.

1992 • 45 citations

The MAP kinase phosphorylation site of TAL1 occurs within a transcriptional activation domain.

1994 • 34 citations

Terminal differentiation of human erythroleukemia cell line K562 induced by aphidicolin

1990 • 31 citations

Regulation of Gene Transcription During the Differentiation of Megakaryocytes

1995 • 21 citations

Biosynthesis and Processing of Platelet Glycoproteins in Megakaryocytes

1991 • 4 citations

Megakaryocyte Maturation and Platelet Release in Normal and Pathologic Conditions

1991 • 3 citations