High-level expression of c-H-ras1 fails to fully transform rat-1 cells.

Transformation of mammalian cells to antibiotic resistance with a bacterial gene under control of the SV40 early region promoter.

1982 • 2,753 citations

Prevalence of ras gene mutations in human colorectal cancers

1987 • 1,866 citations

G proteins and dual control of adenylate cyclase

1984 • 1,811 citations

Autocrine growth factors and cancer

1985 • 1,462 citations

Growth factors from murine sarcoma virus-transformed cells.

1978 • 1,457 citations

Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor

1978 • 1,284 citations

Detection of high incidence of K-ras oncogenes during human colon tumorigenesis

1987 • 1,074 citations

Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologue

1983 • 1,028 citations

Isolation of Chinese hamster cell mutants deficient in dihydrofolate reductase activity.

1980 • 903 citations

Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors.

1980 • 892 citations

Expression of Cellular Oncogenes in Human Malignancies

1984 • 840 citations

Comparative biochemical properties of normal and activated human ras p21 protein

1984 • 713 citations

Suppression of Malignancy by Cell Fusion

1969 • 613 citations

Intrinsic GTPase activity distinguishes normal and oncogenic ras p21 molecules.

1984 • 607 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

Biological properties of human c-Ha-ras1 genes mutated at codon 12

1984 • 586 citations

Activation of Ki-ras2 gene in human colon and lung carcinomas by two different point mutations

1983 • 553 citations

The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity

1984 • 539 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction.

1980 • 461 citations

Isolation and expression of an altered mouse dihydrofolate reductase cDNA.

1983 • 436 citations

Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production

1986 • 406 citations

Malignant Activation of a K- ras Oncogene in Lung Carcinoma But Not in Normal Tissue of the Same Patient

1984 • 395 citations

Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors.

1983 • 381 citations

Alterations of myc , myb , and ras ^Ha Proto-Oncogenes In Cancers Are Frequent and Show Clinical Correlation

1986 • 379 citations

Structure of the Ki-ras gene of the human lung carcinoma cell line Calu-1

1983 • 377 citations

Human Cell Hybrids: Analysis of Transformation and Tumorigenicity

1982 • 349 citations

Expression of a Cellular Oncogene During Liver Regeneration

1983 • 281 citations

Differential expression of the ras gene family in mice.

1987 • 222 citations

ras gene Amplification and malignant transformation.

1985 • 204 citations

Elevated expression of the human ras oncogene family in premalignant and malignant tumours of the colorectum

1984 • 195 citations

Expression of v-src and chicken c-src in rat cells demonstrates qualitative differences between pp60v-src and pp60c-src

1984 • 194 citations

Mutation Affecting the 12th Amino Acid of the c-Ha- ras Oncogene Product Occurs Infrequently in Human Cancer

1983 • 162 citations

Overexpression of the c-src protein does not induce transformation of NIH 3T3 cells.

1984 • 161 citations

Differential responsiveness of myc- and ras-transfected cells to growth factors: selective stimulation of myc-transfected cells by epidermal growth factor.

1986 • 159 citations

Opposing effects of a ras oncogene on growth factor-stimulated phosphoinositide hydrolysis: desensitization to platelet-derived growth factor and enhanced sensitivity to bradykinin.

1987 • 125 citations

Ras p21 proteins with high or low GTPase activity can efficiently transform NIH3T3 cells

1986 • 118 citations

Biochemical and biological properties of the human N-ras p21 protein.

1987 • 106 citations

Human malignant tumours of the breast, as compared to their respective normal tissue, have elevated expression of the Harvey ras oncogene.

1984 • 103 citations

Suppression of tumorigenicity with continued expression of the c-Ha-ras oncogene in EJ bladder carcinoma-human fibroblast hybrid cells.

1986 • 94 citations

Suppression of tumorigenicity in hybrids of normal and oncogene-transformed CHEF cells.

1985 • 91 citations

Normal and activated ras oncogenes and their encoded products

1986 • 72 citations

Harvey ras genes transform without mutant codons, apparently activated by truncation of a 5' exon (exon -1).

1986 • 60 citations

Dose effects of transfected c-Ha-rasVal 12 oncogene in transformed cell clones

1987 • 59 citations

Biochemical characterization of polypeptides encoded by mutated human Ha-ras1 genes.

1986 • 42 citations

Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes.

1986 • 37 citations

Analysis of viral and somatic activations of the cHa-ras gene

1985 • 36 citations