Genetic analysis of the Kirsten-ras-revertant 1 gene: potentiation of its tumor suppressor activity by specific point mutations.

High-efficiency transformation of mammalian cells by plasmid DNA.

1987 • 5,377 citations

ras GENES

1987 • 3,818 citations

Number and evolutionary conservation of α- and β-tubulin and cytoplasmic β- and γ-actin genes using specific cloned cDNA probes

1980 • 1,884 citations

A ras-related gene with transformation suppressor activity

1989 • 979 citations

Structure of the guanine-nucleotide-binding domain of the Ha-ras oncogene product p21 in the triphosphate conformation

1989 • 881 citations

Inhibition of NIH 3T3 Cell Proliferation by a Mutant ras Protein with Preferential Affinity for GDP

1988 • 757 citations

ras GTPase activating protein: Signal transmitter and signal terminator

1989 • 621 citations

Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virus

1982 • 599 citations

The p21 ras C-terminus is required for transformation and membrane association

1984 • 590 citations

Biological and biochemical properties of human rasH genes mutated at codon 61

1986 • 538 citations

PDGF induction of tyrosine phosphorylation of GTPase activating protein

1989 • 478 citations

Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1

1983 • 441 citations

Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region.

1988 • 334 citations

Identification of effector residues and a neutralizing epitope of Ha-ras-encoded p21.

1986 • 291 citations

Analysis of the transforming potential of the human H-ras gene by random mutagenesis.

1984 • 290 citations

Mutant ras-encoded proteins with altered nucleotide binding exert dominant biological effects.

1986 • 285 citations

A Model for the Tertiary Structure of p21, the Product of the ras Oncogene

1985 • 248 citations

Flat revertants isolated from Kirsten sarcoma virus-transformed cells are resistant to the action of specific oncogenes.

1983 • 221 citations

Mutational analysis of a ras catalytic domain.

1986 • 205 citations

ras gene Amplification and malignant transformation.

1985 • 204 citations

A novel small molecular weight GTP-binding protein with the same putative effector domain as the ras proteins in bovine brain membranes. Purification, determination of primary structure, and characterization.

1988 • 185 citations

Detection of genes with a potential for suppressing the transformed phenotype associated with activated ras genes.

1989 • 141 citations

Purification and Characterization from Bovine Brain Cytosol of Two Gtpase-Activating Proteins Specific for smg p21, a GTP-binding Protein Having the Same Effector Domain as c-ras p21s

1989 • 120 citations

Activated N-ras controls the transformed phenotype of HT1080 human fibrosarcoma cells

1987 • 109 citations

Processing and fatty acid acylation of RAS1 and RAS2 proteins in Saccharomyces cerevisiae.

1986 • 108 citations

Characterization of functional domains of p21 ras by use of chimeric genes.

1985 • 60 citations

ras gene Amplification and Malignant Transformation

1985 • 57 citations

Mutational Analysis of a ras Catalytic Domain

1986 • 36 citations