Signaling requirements for the expression of the transactivating factor NF‐AT in human T lymphocytes

A new generation of Ca2+ indicators with greatly improved fluorescence properties.

1985 • 21,873 citations

T Cell Growth Factor: Parameters of Production and a Quantitative Microassay for Activity

1978 • 3,314 citations

Phorbol ester-inducible genes contain a common cis element recognized by a TPA-modulated trans-acting factor

1987 • 3,057 citations

Interleukin-2: Inception, Impact, and Implications

1988 • 2,166 citations

Inducibility of κ immunoglobulin enhancer-binding protein NF-κB by a posttranslational mechanism

1986 • 2,043 citations

Changes in the levels of inositol phosphates after agonist-dependent hydrolysis of membrane phosphoinositides

1983 • 1,937 citations

The Interleukin-2 T-Cell System: A New Cell Growth Model

1984 • 935 citations

Identification of a Putative Regulator of Early T Cell Activation Genes

1988 • 933 citations

Interaction between CD4 and class II MHC molecules mediates cell adhesion

1987 • 823 citations

Early steps of lymphocyte activation bypassed by synergy between calcium ionophores and phorbol ester

1985 • 753 citations

Cyclosporin A Specifically Inhibits Function of Nuclear Proteins Involved in T Cell Activation

1989 • 679 citations

Commentary: “The Role of T3 Surface Molecules in the Activation of Human Cells: A Two-Stimulus Requirement for IL-2 Production Reflects Events Occurring at a Pretranslational Level”

2015 • 572 citations

Inhibition of tyrosine phosphorylation prevents T-cell receptor-mediated signal transduction.

1990 • 526 citations

Transmission of Signals from the T Lymphocyte Antigen Receptor to the Genes Responsible for Cell Proliferation and Immune Function: The Missing Link

1990 • 517 citations

The role of T3 surface molecules in the activation of human T cells: a two-stimulus requirement for IL 2 production reflects events occurring at a pre-translational level.

1984 • 455 citations

Characterization of antigen receptor response elements within the interleukin-2 enhancer.

1988 • 451 citations

Cell-cell adhesion mediated by CD8 and MHC class I molecules

1988 • 445 citations

Antigen activation of murine T cells induces tyrosine phosphorylation of a polypeptide associated with the T cell antigen receptor

1986 • 387 citations

Kappa B-Specific DNA Binding Proteins: Role in the Regulation of Human Interleukin-2 Gene Expression

1989 • 327 citations

Inducible binding of a factor to the c-fos enhancer

1986 • 310 citations

Single cell assay of a transcription factor reveals a threshold in transcription activated by signals emanating from the T-cell antigen receptor.

1990 • 292 citations

Regulation of human interleukin-2 gene: Functional DNA sequences in the 5′ flanking region for the gene expression in activated T lymphocytes

1986 • 288 citations

Interleukin-1 Costimulatory Activity on the Interleukin-2 Promoter Via AP-1

1989 • 271 citations

Structure, Function, and Serology of the T-Cell Antigen Receptor Complex

1987 • 264 citations

A 275 basepair fragment at the 5' end of the interleukin 2 gene enhances expression from a heterologous promoter in response to signals from the T cell antigen receptor.

1987 • 174 citations

NF-kappa B protein purification from bovine spleen: nucleotide stimulation and binding site specificity.

1988 • 148 citations

Transmembrane signalling via the T11‐dependent pathway of human T cell activation. Evidence for the involvement of 1,2‐diacylglycerol and inositol phosphates

1987 • 137 citations

T cell activation via CD2 [T, gp50]: the role of accessory cells in activating resting T cells via CD2.

1986 • 105 citations

Dissociation of phosphoinositide hydrolysis and Ca2+ fluxes from the biological responses of a T-cell hybridoma

1988 • 102 citations

Cell type specificity and activation requirements for NFAT-1 (nuclear factor of activated T-cells) transcriptional activity determined by a new method using transgenic mice to assay transcriptional activity of an individual nuclear factor.

1990 • 101 citations

The promoter of the human interleukin-2 gene contains two octamer-binding sites and is partially activated by the expression of Oct-2.

1990 • 91 citations

Distinct patterns of transmembrane calcium flux and intracellular calcium mobilization after differentiation antigen cluster 2 (E rosette receptor) or 3 (T3) stimulation of human lymphocytes.

1986 • 89 citations

Activation of tyrosine phosphorylation in human T cells via the CD2 pathway. Regulation by the CD45 tyrosine phosphatase.

1990 • 87 citations

Transmembrane signalling by the T3-antigen receptor complex

1985 • 82 citations

A method for measuring protein kinase C activity in permeabilized T lymphocytes by using peptide substrates. Evidence for multiple pathways of kinase activation

1990 • 81 citations

T cell stimulation via the erythrocyte receptor. Synergism between monoclonal antibodies and phorbol myristate acetate without changes of free cytoplasmic Ca++ levels.

1986 • 81 citations

Activation of human T lymphocytes via the CD2 antigen results in tyrosine phosphorylation of T cell antigen receptor zeta-chains.

1990 • 65 citations

Nuclear factors interacting with the mitogen-responsive regulatory region of the interleukin-2 gene.

1988 • 53 citations

Autocrine regulation of T-lymphocyte proliferation: differential induction of IL-2 and IL-2 receptor.

1988 • 53 citations

Tyrosine phosphorylation of the human T cell antigen receptor zeta-chain: activation via CD3 but not CD2.

1988 • 48 citations

Evidences for protein kinase C. Activation in T lymphocytes by stimulation of either the CD2 or CD3 antigens

1989 • 38 citations

Stimulation via CD3-Ti but not CD2 induces rapid tyrosine phosphorylation of a 68-kDa protein in the human Jurkat T cell line.

1990 • 32 citations

Helper or cytolytic functions can be selectively induced in bifunctional T cell clones.

1990 • 20 citations