Evidence for defective transmembrane signaling in B cells from patients with Wiskott-Aldrich syndrome.

PEDIGREE DEMONSTRATING A SEX-LINKED RECESSIVE CONDITION CHARACTERIZED BY DRAINING EARS, ECZEMATOID DERMATITIS AND BLOODY DIARRHEA

1954 • 512 citations

Association of B Cell Antigen Receptor with Protein Tyrosine Kinase Lyn

1991 • 471 citations

The leukocyte common antigen (CD45): a putative receptor-linked protein tyrosine phosphatase.

1988 • 435 citations

Demonstration that the leukocyte common antigen (CD45) is a protein tyrosine phosphatase

1988 • 425 citations

Wiskott-Aldrich syndrome

1968 • 422 citations

Molecular components of the B-cell antigen receptor complex of the IgM class

1990 • 401 citations

Identification of multiple novel polypeptide substrates of the v-src, v-yes, v-fps, v-ros, and v-erb-B oncogenic tyrosine protein kinases utilizing antisera against phosphotyrosine.

1988 • 351 citations

Stimulation of protein tyrosine phosphorylation by the B-lymphocyte antigen receptor

1990 • 346 citations

The CBA/N Mouse Strain: An Experimental Model Illustration the Influence of the X-Chromosome on Immunity

1982 • 305 citations

B lymphocyte lineage-restricted expression of mb-1, a gene with CD3-like structural properties.

1988 • 283 citations

Specific Expression of a Tyrosine Kinase Gene, blk , in B Lymphoid Cells

1990 • 234 citations

Protein tyrosine phosphorylation is induced in murine B lymphocytes in response to stimulation with anti-immunoglobulin.

1990 • 225 citations

CD45 regulates signal transduction and lymphocyte activation by specific association with receptor molecules on T or B cells.

1988 • 223 citations

The B-cell antigen receptor complex

1991 • 213 citations

Tyrosine phosphorylation of phospholipase C induced by membrane immunoglobulin in B lymphocytes.

1991 • 205 citations

Effect of Phospholipase C-γ Overexpression on PDGF-induced Second Messengers and Mitogenesis

1990 • 170 citations

Picogram quantities of anti-Ig antibodies coupled to dextran induce B cell proliferation.

1988 • 156 citations

Defective Lymphocyte Transformation and Delayed Hypersensitivity in Wiskott-Aldrich Syndrome

1970 • 147 citations

Aberrant O-linked oligosaccharide biosynthesis in lymphocytes and platelets from patients with the Wiskott-Aldrich syndrome.

1991 • 146 citations

IgM antigen receptor complex contains phosphoprotein products of B29 and mb-1 genes.

1991 • 138 citations

Interleukin 2-induced lymphocyte proliferation is independent of increases in cytosolic-free calcium concentrations.

1985 • 113 citations

Interleukin 2 does not induce phosphatidylinositol hydrolysis in activated T cells.

1986 • 102 citations

Guanine nucleotides induce tyrosine phosphorylation and activation of the respiratory burst in neutrophils

1989 • 101 citations

Wiskott-Aldrich syndrome: cellular impairments and their implication for carrier detection

1980 • 96 citations

X-Chromosome inactivation in the Wiskott-Aldrich syndrome: A marker for detection of the carrier state and identfication of cell lineages expressing the gene defect

1989 • 94 citations

G protein coupling of antigen receptor-stimulated polyphosphoinositide hydrolysis in B cells.

1988 • 89 citations

Involvement of a guanine-nucleotide-binding component in membrane IgM-stimulated phosphoinositide breakdown.

1987 • 86 citations

Differences in glycoprotein complexes associated with IgM and IgD on normal murine B cells potentially enable transduction of different signals.

1990 • 78 citations

Analysis of signaling via surface immunoglobulin receptors on b cells from cba/n mice

1989 • 70 citations

Activation of phospholipase C in human B cells is dependent on tyrosine phosphorylation.

1991 • 68 citations

Membrane IgM and IgD molecules fail to transduce Ca2+ mobilizing signals when expressed on differentiated B lineage cells.

1990 • 67 citations

Increased phosphatidylinositol metabolism is an important but not an obligatory early event in B lymphocyte activation.

1985 • 67 citations

The membrane IgM-associated heterodimer on human B cells is a newly defined B cell antigen that contains the protein product of the mb-1 gene.

1991 • 66 citations

G protein regulation of receptor signalling

1988 • 58 citations

The Mn2+-activated incorporation of inositol into molecular species of phosphatidylinositol in rat liver microsomes

1974 • 56 citations

Signalling in B cells

1991 • 51 citations

Newborn and Wiskott-Aldrich patient B cells can be activated by TNP-Brucella abortus: evidence that TNP-Brucella abortus behaves as a T-independent type 1 antigen in humans.

1984 • 34 citations

Muscarinic-receptor stimulation enhances polyphosphoinositide breakdown in guinea-pig ileum smooth muscle

1984 • 28 citations

The increase of non-MHC-restricted cytotoxic cells ( T cells or NK cells) and the abnormal differentiation of B cells in Wiskott-Aldrich syndrome

1989 • 25 citations

The Wiskott-Aldrich syndrome. Immunologic studies in nine patients and selected family members

1975 • 24 citations

Phospholipid synthesis by activated human B lymphocytes.

1983 • 9 citations