The modification and assembly of proteins in the endoplasmic reticulum

Protein folding in the cell

1992 • 4,138 citations

A C-terminal signal prevents secretion of luminal ER proteins

1987 • 2,189 citations

Oxidized Redox State of Glutathione in the Endoplasmic Reticulum

1992 • 1,909 citations

Three-dimensional structure of the ATPase fragment of a 70K heat-shock cognate protein

1990 • 1,035 citations

Peptide-binding specificity of the molecular chaperone BiP

1991 • 763 citations

Degradation from the endoplasmic reticulum: Disposing of newly synthesized proteins

1988 • 488 citations

Manipulating disulfide bond formation and protein folding in the endoplasmic reticulum.

1992 • 405 citations

A view of acidic intracellular compartments.

1988 • 380 citations

A 22 bp cis-acting element is necessary and sufficient for the induction of the yeast KAR2 (BiP) gene by unfolded proteins.

1992 • 375 citations

Vesicles and cisternae in the trans golgi apparatus of human fibroblasts are acidic compartments

1985 • 350 citations

Overexpression of GRP78 mitigates stress induction of glucose regulated proteins and blocks secretion of selective proteins in Chinese hamster ovary cells.

1992 • 348 citations

The Promoter Region of the Yeast KAR2 (BiP) Gene Contains a Regulatory Domain that Responds to the Presence of Unfolded Proteins in the Endoplasmic Reticulum

1993 • 328 citations

Protein disulfide isomerase. A multifunctional protein resident in the lumen of the endoplasmic reticulum.

1992 • 318 citations

The involvement of calcium in transport of secretory proteins from the endoplasmic reticulum

1990 • 310 citations

Role of ATP and disulphide bonds during protein folding in the endoplasmic reticulum

1992 • 286 citations

Endoplasmic reticulum resident protein of 90 kilodaltons associates with the T- and B-cell antigen receptors and major histocompatibility complex antigens during their assembly.

1992 • 259 citations

The promoter region of the yeast KAR2 (BiP) gene contains a regulatory domain that responds to the presence of unfolded proteins in the endoplasmic reticulum.

1993 • 246 citations

The ERD2 gene determines the specificity of the luminal ER protein retention system

1990 • 243 citations

The endoplasmic reticulum stress protein GRP94, in addition to BiP, associates with unassembled immunoglobulin chains.

1992 • 243 citations

Involvement of the stress protein HSP47 in procollagen processing in the endoplasmic reticulum

1992 • 241 citations

Calreticulin, and not calsequestrin, is the major calcium binding protein of smooth muscle sarcoplasmic reticulum and liver endoplasmic reticulum.

1991 • 236 citations

Calcium is required for folding of newly made subunits of the asialoglycoprotein receptor within the endoplasmic reticulum.

1992 • 234 citations

pH-dependent binding of KDEL to its receptor in vitro.

1993 • 232 citations

A Peptide Sequence Confers Retention and Rapid Degradation in the Endoplasmic Reticulum

1990 • 219 citations

Identity of the immunoglobulin heavy-chain-binding protein with the 78,000-dalton glucose-regulated protein and the role of posttranslational modifications in its binding function.

1988 • 211 citations

Regulating the retention of T-cell receptor alpha chain variants within the endoplasmic reticulum: Ca(2+)-dependent association with BiP.

1991 • 210 citations

Four Intracisternal Calcium-binding Glycoproteins from Rat Liver Microsomes with High Affinity for Calcium

1989 • 200 citations

Interaction of BiP with newly synthesized immunoglobulin light chain molecules: cycles of sequential binding and release.

1992 • 187 citations

Efficient dissociation of the p88 chaperone from major histocompatibility complex class I molecules requires both beta 2-microglobulin and peptide.

1992 • 184 citations

Interconversion of three differentially modified and assembled forms of BiP.

1992 • 180 citations

Interaction of heavy chain binding protein (BiP/GRP78) with adenine nucleotides.

1989 • 176 citations

Immunoglobulin heavy chain and binding protein complexes are dissociated in vivo by light chain addition.

1990 • 174 citations

Gadd45 and Gadd153 messenger RNA levels are increased during hypoxia and after exposure of cells to agents which elevate the levels of the glucose-regulated proteins.

1992 • 173 citations

Site-directed mutagenesis of human protein disulphide isomerase: effect on the assembly, activity and endoplasmic reticulum retention of human prolyl 4-hydroxylase in Spodoptera frugiperda insect cells.

1992 • 152 citations

Transactivation of the grp78 promoter by malfolded proteins, glycosylation block, and calcium ionophore is mediated through a proximal region containing a CCAAT motif which interacts with CTF/NF-I.

1991 • 151 citations

HLA-DR associates with specific stress proteins and is retained in the endoplasmic reticulum in invariant chain negative cells.

1992 • 148 citations

Expression and site-directed mutagenesis of human protein disulfide isomerase in Escherichia coli. This multifunctional polypeptide has two independently acting catalytic sites for the isomerase activity.

1992 • 144 citations

Catalysis of the oxidative folding of ribonuclease A by protein disulfide isomerase: pre-steady-state kinetics and the utilization of the oxidizing equivalents of the isomerase

1991 • 136 citations

Translocation of ATP into the lumen of rough endoplasmic reticulum-derived vesicles and its binding to luminal proteins including BiP (GRP 78) and GRP 94.

1992 • 131 citations

HSP47: a tissue-specific, transformation-sensitive, collagen-binding heat shock protein of chicken embryo fibroblasts.

1991 • 129 citations

Phosphorylation of eukaryotic initiation factor (eIF) 2 alpha and inhibition of eIF-2B in GH3 pituitary cells by perturbants of early protein processing that induce GRP78.

1992 • 122 citations

s-cyclophilin is retained intracellularly via a unique COOH-terminal sequence and colocalizes with the calcium storage protein calreticulin.

1992 • 118 citations

Mutations within the nucleotide binding site of immunoglobulin-binding protein inhibit ATPase activity and interfere with release of immunoglobulin heavy chain.

1993 • 113 citations

In vivo cross-linking of protein disulfide isomerase to immunoglobulins

1987 • 113 citations

Transient aggregation of nascent thyroglobulin in the endoplasmic reticulum: relationship to the molecular chaperone, BiP.

1992 • 112 citations

Cell-free synthesis and assembly of prolyl 4-hydroxylase: the role of the beta-subunit (PDI) in preventing misfolding and aggregation of the alpha-subunit.

1993 • 112 citations

The p88 molecular chaperone is identical to the endoplasmic reticulum membrane protein, calnexin.

1992 • 110 citations

The sequence of the mu transmembrane segment determines the tissue specificity of the transport of immunoglobulin M to the cell surface.

1990 • 101 citations

The rubella virus E1 glycoprotein is arrested in a novel post-ER, pre-Golgi compartment.

1992 • 100 citations

Protein degradation by the phosphoinositide-specific phospholipase C-alpha family from rat liver endoplasmic reticulum.

1992 • 100 citations

The 5'-flanking region of the human calreticulin gene shares homology with the human GRP78, GRP94, and protein disulfide isomerase promoters.

1992 • 99 citations

Brefeldin A, thapsigargin, and AlF stimulate the accumulation of GRP78 mRNA in a cycloheximide dependent manner, whilst induction by hypoxia is independent of protein synthesis

1992 • 98 citations

Heavy chain binding protein (BiP/GRP78) and endoplasmin are exported from the endoplasmic reticulum in rat exocrine pancreatic cells, similar to protein disulfide-isomerase

1992 • 96 citations

ATP is required for in vitro assembly of MHC class I antigens but not to transfer of peptides acrosss the ER membrane

1991 • 92 citations

A permeabilized cell system identifies the endoplasmic reticulum as a site of protein degradation.

1991 • 90 citations

Different sorting of Lys-Asp-Glu-Leu proteins in rat liver.

1992 • 89 citations

Sequence of a second human KDEL receptor

1992 • 85 citations

Immunoelectron microscopic localization of acidic intracellular compartments in hepatoma cells.

1985 • 83 citations

BIP—A Heat Shock Protein Involved in Immunoglobulin Chain Assembly

1991 • 81 citations

Translocation of TCRα Chains into the Lumen of the Endoplasmic Reticulum and Their Degradation

1993 • 75 citations

The major histocompatibility complex class I antigen-binding protein p88 is the product of the calnexin gene.

1992 • 74 citations

Endoplasmic reticulum degradation of a subunit of the asialoglycoprotein receptor in vitro. Vesicular transport from endoplasmic reticulum is unnecessary.

1992 • 74 citations

An endoplasmic reticulum retention signal in the CD3ɛ chain of the T-cell receptor

1992 • 67 citations

Folding in vitro of bovine pancreatic trypsin inhibitor in the presence of proteins of the endoplasmic reticulum

1992 • 65 citations

Regulation of endoplasmic reticulum stress proteins in COS cells transfected with immunoglobulin mu heavy chain cDNA.

1991 • 63 citations

The endoplasmic reticulum retention signal of the E3/19K protein of adenovirus type 2 consists of three separate amino acid segments at the carboxy terminus.

1990 • 60 citations

3-Hydroxy-3-methylglutaryl-coenzyme A reductase and T cell receptor alpha subunit are differentially degraded in the endoplasmic reticulum.

1992 • 52 citations

Calcium-dependent autophosphorylation of the glucose-regulated protein, Grp78

1991 • 46 citations

Tetrameric cell-surface MHC class I molecules

1992 • 41 citations

Autophosphorylation of 70 kDa heat shock proteins.

1992 • 37 citations

Promoter of the gene for the multifunctional protein disulfide isomerase polypeptide. Functional significance of the six CCAAT boxes and other promoter elements.

1992 • 32 citations

The immunoglobulin-binding protein in vitro autophosphorylation site maps to a threonine within the ATP binding cleft but is not a detectable site of in vivo phosphorylation

1993 • 30 citations