Multidrug resistance in brain tumors: roles of the blood-brain barrier.

Overexpression of a Transporter Gene in a Multidrug-Resistant Human Lung Cancer Cell Line

1992 • 3,039 citations

Cellular localization of the multidrug-resistance gene product P-glycoprotein in normal human tissues.

1987 • 2,788 citations

Genes Expressed in Human Tumor Endothelium

2000 • 1,838 citations

A Family of Drug Transporters: the Multidrug Resistance-Associated Proteins

2000 • 1,723 citations

Expression of a multidrug-resistance gene in human tumors and tissues.

1987 • 1,547 citations

Matrix Metalloproteinases: Biologic Activity and Clinical Implications

2000 • 1,533 citations

Expression of a full-length cDNA for the human "MDR1" gene confers resistance to colchicine, doxorubicin, and vinblastine.

1987 • 1,080 citations

Expression of the multidrug resistance gene product (P-glycoprotein) in human normal and tumor tissues.

1990 • 1,063 citations

Mammalian multidrug resistance gene: Complete cDNA sequence indicates strong homology to bacterial transport proteins

1986 • 1,058 citations

P-Glycoprotein, a gatekeeper in the blood–brain barrier

1999 • 918 citations

Filipin-sensitive caveolae-mediated transport in endothelium: reduced transcytosis, scavenger endocytosis, and capillary permeability of select macromolecules.

1994 • 894 citations

Reduced permeability in CHO cells as a mechanism of resistance to colchicine

1974 • 695 citations

Isolation of human mdr DNA sequences amplified in multidrug-resistant KB carcinoma cells.

1986 • 688 citations

The multidrug resistance protein family

1999 • 654 citations

MRP3, an organic anion transporter able to transport anti-cancer drugs

1999 • 639 citations

In vitro and in vivo reversal of multidrug resistance by GF120918, an acridonecarboxamide derivative.

1993 • 526 citations

Tissue distribution of the multidrug resistance protein.

1996 • 473 citations

Role of plasmalemmal caveolae in signal transduction

1998 • 466 citations

Claudin-1 and claudin-5 expression and tight junction morphology are altered in blood vessels of human glioblastoma multiforme

2000 • 456 citations

Antifolate resistance mediated by the multidrug resistance proteins MRP1 and MRP2.

1999 • 444 citations

Two members of the mouse mdr gene family confer multidrug resistance with overlapping but distinct drug specificities.

1990 • 420 citations

Matrix metalloproteinase inhibition by green tea catechins

2000 • 419 citations

Osmotic opening of the blood-brain barrier: principles, mechanism, and therapeutic applications.

2000 • 395 citations

Analysis of the expression of MRP, the gene for a new putative transmembrane drug transporter, in human multidrug resistant lung cancer cell lines

1994 • 315 citations

Inhibition of the multidrug resistance P-glycoprotein activity by green tea polyphenols

2002 • 306 citations

Up-regulation of Caveolae and Caveolar Constituents in Multidrug-resistant Cancer Cells

1998 • 298 citations

Caveolin Is an Activator of Insulin Receptor Signaling

1998 • 297 citations

Mrp1 Multidrug Resistance‐Associated Protein and P‐Glycoprotein Expression in Rat Brain Microvessel Endothelial Cells

1998 • 265 citations

P-glycoprotein is strongly expressed in the luminal membranes of the endothelium of blood vessels in the brain

1997 • 249 citations

Expression of various multidrug resistance-associated protein (MRP) homologues in brain microvessel endothelial cells

2000 • 233 citations

Green tea catechins inhibit vascular endothelial growth factor receptor phosphorylation.

2002 • 205 citations

Expression of Multidrug Resistance-Associated Protein (MRP) in Brain Microvessel Endothelial Cells

1998 • 202 citations

Multidrug Resistance Protein 1 Protects the Oropharyngeal Mucosal Layer and the Testicular Tubules against Drug-induced Damage

1998 • 200 citations

Extensive contribution of the multidrug transporters P-glycoprotein and Mrp1 to basal drug resistance.

2000 • 196 citations

Efflux transport systems for drugs at the blood–brain barrier and blood–cerebrospinal fluid barrier (Part 1)

2001 • 173 citations

Carrier-mediated or specialized transport of drugs across the blood–brain barrier

1999 • 164 citations

Functional expression of p-glycoprotein and multidrug resistance-associated protein (mrp1) in primary cultures of rat astrocytes

2000 • 156 citations

Upregulation of caveolin‐1 and caveolae organelles in Taxol‐resistant A549 cells

1998 • 154 citations

P‐glycoprotein is localized in caveolae in resistant cells and in brain capillaries

2000 • 153 citations

Localization of a novel multidrug resistance-associated gene in the HT1080/DR4 and H69AR human tumor cell lines.

1993 • 153 citations

Reversal of Multidrug Resistance by the P-Glycoprotein Modulator, LY335979, from the Bench to the Clinic

2001 • 147 citations

Vector-mediated drug delivery to the brain

1999 • 140 citations

Multidrug Resistance‐Related Transport Proteins in Isolated Human Brain Microvessels and in Cells Cultured from These Isolates

1998 • 139 citations

A critique of the role of the blood-brain barrier in the chemotherapy of human brain tumors

1994 • 133 citations

Cellular and biochemical characterization of VX-710 as a chemosensitizer

1997 • 131 citations

Determinants of passive drug entry into the central nervous system.

2000 • 127 citations

MDR1 P-glycoprotein is expressed by endothelial cells of newly formed capillaries in human gliomas but is not expressed in the neovasculature of other primary tumors.

1996 • 117 citations

Brain drug delivery, drug metabolism, and multidrug resistance at the choroid plexus

2000 • 115 citations

Ultrastructural and Morphometric Investigation of Human Brain Capillaries in Normal and Peritumoral Tissues

1997 • 107 citations

Isolation of Endothelial Cells from Brain, Lung, and Kidney: Expression of the Multidrug Resistance P-Glycoprotein Isoforms

2001 • 104 citations

The response of cerebral metastases in small cell lung cancer to systemic chemotherapy

1990 • 104 citations

Unlocking the Blood–Brain Barrier: A Role for RMP-7 in Brain Tumor Therapy

1996 • 101 citations

Immunohistochemical detection of multidrug resistance protein in human lung cancer and normal lung.

1998 • 98 citations

Specialized Localization of P‐Glycoprotein Recognized by MRK 16 Monoclonal Antibody in Endothelial Cells of the Brain and the Spinal Cord

1990 • 97 citations

Characterization of efflux transport of organic anions in a mouse brain capillary endothelial cell line.

1998 • 94 citations

Possible involvement of multidrug‐resistance‐associated protein (MRP) gene expression in spontaneous drug resistance to vincristine, etoposide and adriamycin in human glioma cells

1994 • 89 citations

Expression of multidrug-resistance P-glycoprotein (MDR1) in human brain tumors

2001 • 89 citations

Phase I/II Study of the P-Glycoprotein Modulator PSC 833 in Patients With Acute Myeloid Leukemia

2001 • 85 citations

P-glycoprotein expression in brain tumors

1992 • 83 citations

Kinetic and biochemical analysis of carrier-mediated efflux of drugs through the blood–brain and blood–cerebrospinal fluid barriers: importance in the drug delivery to the brain

1999 • 82 citations

Ultrastructure of capillary walls in human brain tumors

1989 • 77 citations

Multidrug resistance gene (MDR1) expression in human brain tumors

1991 • 75 citations

Brain microvascular P-glycoprotein and a revised model of multidrug resistance in brain.

2000 • 73 citations

Cellular localization of P-glycoprotein in brain versus gonadal capillaries.

1996 • 73 citations

The multidrug-resistance gene MDR1 is expressed in human glial tumors

1991 • 71 citations

Expression of multidrug resistance-associated protein (MRP) in human gliomas.

2000 • 71 citations

The glucose transporter and blood‐brain barrier of human brain tumors

1990 • 69 citations

Endocytosis and transcytosis

1998 • 67 citations

Modulation of multidrug resistance protein expression in porcine brain capillary endothelial cells in vitro.

1999 • 66 citations

Matrix proteinase inhibition by AE-941, a multifunctional antiangiogenic compound.

2001 • 62 citations

Enhanced delivery of carboplatin into brain tumours with intravenous CereportTM (RMP-7): dramatic differences and insight gained from dosing parameters

1999 • 62 citations

Dose-dependent brain penetration of SDZ PSC 833, a novel multidrug resistance-reversing cyclosporin, in rats

1996 • 60 citations

Phase II studies of RMP-7 and carboplatin in the treatment of recurrent high grade glioma. RMP-7 European Study Group.

1999 • 60 citations

Expression of P-glycoprotein in human glioma cell lines and surgical glioma specimens

1991 • 56 citations

Expression of the multidrug-resistance P-glycoprotein (Pgp, MDR-1) by endothelial cells of the neovasculature in central nervous system tumors

1999 • 52 citations

Involvement of the Multidrug Resistance Protein 3 in Drug Sensitivity and Its Expression in Human Glioma

2001 • 52 citations

Inhibitory effect of epigallocatechin-gallate on brain tumor cell lines in vitro

2001 • 49 citations

Isoform I (mdr3) is the major form of P-glycoprotein expressed in mouse brain capillaries. Evidence for cross-reactivity of antibody C219 with an unrelated protein

1995 • 47 citations

P-glycoprotein overexpression cannot explain the complete doxorubicin-resistance phenotype in rat glioblastoma cell lines

1992 • 45 citations

P-glycoprotein: Its role in drug resistance

1995 • 43 citations

Multidrug Resistance in Glioblastoma

1998 • 28 citations

Immunohistochemical study of tight junction-related protein in neovasculature in astrocytic tumor

2000 • 27 citations

Does P-glycoprotein play a role in clinical resistance of malignant astrocytoma?

1999 • 23 citations

Preface: Targeted Drug Delivery to the Brain (Blood-Brain Barrier, Efflux, Endothelium, Biological Transport)

2000 • 18 citations

Selective Lutheran Glycoprotein Gene Expression at the Blood—Brain Barrier in Normal Brain and in Human Brain Tumors

2000 • 17 citations

Reversal of chemoresistance in malignant gliomas by calcium antagonists: correlation with the expression of multidrug-resistant p-glycoprotein

1994 • 15 citations

Mdr1 mRNA expression differs between grade III astrocytomas and glioblastomas.

1997 • 13 citations